Drug & supplement interaction

Green Coffee + Dasiglucagon Hydrochloride

Dasiglucagon Hydrochloride brand name: Zegalogue.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Green Coffee has a minor interaction with Dasiglucagon Hydrochloride. Theoretically, taking green coffee and antidiabetes drugs might interfere with blood glucose control.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceB
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Green Coffee and Dasiglucagon Hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Dasiglucagon Hydrochloride

Dasiglucagon Hydrochloride falls under ANTIDIABETES DRUGS — the group Green Coffee interacts with.

Theoretically, taking green coffee and antidiabetes drugs might interfere with blood glucose control.
In clinical research, green coffee extract results in modest reductions in blood glucose levels in various populations. However, other reports claim that caffeine might increase or decrease blood sugar levels.
Severity Minor Likelihood Unlikely Evidence B

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the good news first: dasiglucagon (Zegalogue) is a rescue medicine you only reach for in an emergency, when blood sugar has dropped dangerously low. It works fast by telling your liver to dump stored sugar back into your blood. Green coffee is being studied for the opposite reason, since its chlorogenic acid may nudge blood sugar down a little over time. These two aren't really competing in the same moment.

The concern on file is mostly theoretical and rated minor, with mixed, low quality evidence. In a true emergency, dasiglucagon should still do its job. The bigger point is that a daily green coffee supplement could slightly affect your everyday glucose control, so let your pharmacist or doctor know you take it. Don't change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
  2. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. PubMed
  3. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007;35:900-8. PubMed
  4. Blum J, Lemaire B, and Lafay S. Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective study. Nutrafoods 2007;6(3):13-17.
  5. Thong FS and Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol (1985). 2002 Jun;92:2347-52.
  6. Greer F, Hudson R, Ross R, et al. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. 2001 Oct;50:2349-54. PubMed
  7. Keijzers GB, De Galan BE, Tack CJ, et al. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25:364-9. PubMed
  8. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78:728-33. PubMed
  9. Chen Y, Zhao Y, Wang Y, et al. The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2020;34(9):2159-2169. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Green Coffee Also Interacts With Other Medications

Green Coffee has 8 major, 442 moderate, 221 minor known drug interactions in our database — the Dasiglucagon Hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 442 Minor 221 No known interaction 2,159 (incl. Dasiglucagon Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Green Coffee

Covers the 2,830 medications we’ve checked against Green Coffee. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dasiglucagon Hydrochloride

This page covers Green Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dasiglucagon Hydrochloride page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Dasiglucagon Hydrochloride page

“Dasiglucagon (Zegalogue) is an emergency injection that rapidly raises blood sugar during a severe diabetic low, so a supplement list this large deserves genuine care. All 239 interacting ingredients act through blood glucose, and most of them lower it, deepening the very crashes this drug exists to reverse.”

Reviewed by 2 · Jul 18, 2026

Open the Dasiglucagon Hydrochloride interaction page

One more smart check

Taking Green Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,716 real supplement products containing Green Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Green Coffee. Your product may carry other ingredients that interact with Dasiglucagon Hydrochloride too, on top of Green Coffee — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Green Coffee and Dasiglucagon Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Green Coffee
Steady interest

#898 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dasiglucagon Hydrochloride
Steady interest

#1,577 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Green Coffee

What is Green Coffee?

Green Coffee
  • Weight loss
  • High blood pressure
  • Blood sugar control
  • Antioxidant support
  • General energy

Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content. Some early studies suggest modest benefits for weight, blood pressure, and blood sugar, but the evidence is limited and far from conclusive. It contains caffeine, so people sensitive to stimulants should use caution and check with a pharmacist or doctor first.

Read the full Green Coffee monograph & all interactions
Medication

About Dasiglucagon Injection

What Is Dasiglucagon Injection Used For?

Brand name: Zegalogue

Zegalogue is used to treat severe hypoglycemia — a dangerously low blood sugar episode — in adults and children aged 6 years and older who have diabetes. Severe hypoglycemia is a medical emergency that requires immediate action.

Zegalogue is not a day-to-day diabetes medicine. It is prescribed as an emergency kit to be on hand in case a person with diabetes becomes unresponsive or cannot safely swallow food or juice to raise their blood sugar.

See full Dasiglucagon Injection drug information
Keep checking

Other Drugs & Green Coffee

Browse every other medication we’ve checked against Green Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
442Moderate
221Minor
2,158No known interaction
8 Major 442 Moderate 221 Minor 2,158 No interaction
Major

8 interactions

Moderate

442 interactions

Showing 60 of 442 moderate interactions — see all 442 on the Green Coffee page.

Minor

221 interactions

Showing 60 of 221 minor interactions — see all 221 on the Green Coffee page.

No interaction 2,158 drugs checked — show the list

We also checked Green Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,158 medications checked with no known interaction — see the full Green Coffee list.

See the full Green Coffee interactions page
See every supplement checked against Dasiglucagon Hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Green Coffee monograph › Uses, safety, and every drug interaction in one place Dasiglucagon Hydrochloride supplement interactions › Every supplement checked against Dasiglucagon Hydrochloride, ranked by severity Dasiglucagon Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Green Coffee and Dasiglucagon Hydrochloride Together: Common Questions

Can you take Green Coffee with Dasiglucagon Hydrochloride?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Green Coffee and Dasiglucagon Hydrochloride interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dasiglucagon Hydrochloride and Green Coffee?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.