Herb & supplement monograph

Ligandrol Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Ligandrol interacts with medications. The heart of this page is the interaction list — every drug Ligandrol is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Ligandrol is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Ligandrol Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, Ligandrol drug interactions deserve a moderate level of caution for most people, mainly because of possible added strain on the liver. Every listed interaction is rated moderate rather than major, and all of them trace back to a single concern about liver health.

Interactions deserving the most attention

The interactions that matter most involve hepatotoxic drugs, meaning medications that can stress or damage the liver. Ligandrol itself has been linked to liver injury in case reports, so combining it with a medicine that also works the liver hard could, in theory, add to that burden. This concern is not well proven in studies, but because liver injury has actually been reported with ligandrol products, we take it seriously.

What the rest of the list means

The long list of interacting medications reflects one shared concern, not hundreds of separate problems: each drug on it can affect the liver. The additive effect is largely theoretical, and no human studies have confirmed that these combinations cause harm. Still, the sheer number simply shows how many common medicines are processed by or can stress the liver, which is why the caution applies broadly.

Check your medications against Ligandrol

Based on HelloPharmacist’s Ligandrol interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Ligandrol

372 medications have a known interaction with Ligandrol, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Ligandrol using our pharmacist-reviewed interaction data.

AI summaries are generated from our Ligandrol interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Ligandrol combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Ligandrol affects

Every type of medication (drug category) Ligandrol is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Ligandrol interacts with

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.

Likelihood Possible Evidence D

Monograph

Ligandrol: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, and has been linked to liver injury and hormonal disruption, so it should not be taken as a supplement.

Part used: Not applicable (synthetic compound)
Common forms: Capsules, tablets, liquid (research chemical), powder

People commonly use it for

Muscle building
Athletic performance and strength
Body recomposition
Bodybuilding cycles

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

Ligandrol is an unapproved investigational drug with real safety concerns and is not a legal dietary supplement.

PregnancyPossibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selecti...

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selecti...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Ligandrol, also called LGD-4033, is a man-made chemical known as a selective androgen receptor modulator (SARM). It is not a plant, herb, or natural product, and it does not come from any botanical source. It was originally developed by a pharmaceutical company and studied as a possible treatment for conditions involving muscle loss, such as those seen with aging or certain illnesses.

Even though it is sometimes sold online as a "dietary supplement" or "research chemical," Ligandrol has not been approved by the FDA for human use. The U.S. Food and Drug Administration has warned that SARMs like Ligandrol are not legal ingredients in dietary supplements. People most often use it in bodybuilding and athletic circles to try to build muscle and increase strength.

How it works

Ligandrol is designed to attach to androgen receptors, the same docking points in the body that natural testosterone uses. SARMs are built to target muscle and bone tissue more than other tissues, with the goal of building muscle while causing fewer effects elsewhere.

By activating androgen receptors in muscle, Ligandrol may signal the body to make more muscle protein, which could increase muscle size and strength. Much of what we know about how it works comes from laboratory and early human studies, and the full effects on the body over time are not well understood. Importantly, even "selective" SARMs can still disrupt natural hormone balance.

Effectiveness

Does Ligandrol work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 7 uses evaluated

7 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Ligandrol, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 7 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Athletic performance