Medication interaction hub

What Supplements Interact with Brompheniramine, Dextromethorphan, Phenylephrine?

Brompheniramine, Dextromethorphan, Phenylephrine brand name: Dimetapp DM. Every interaction below applies to the brands too.

149 Interactions 7 Major 120 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Brompheniramine, Dextromethorphan, Phenylephrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Brompheniramine, Dextromethorphan, Phenylephrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Dimetapp DM, the cold medicine combining brompheniramine, dextromethorphan, and phenylephrine, earns more caution than its over-the-counter status suggests. Seven of the 149 supplement ingredients on this page carry a major rating, and most of those stack stimulant effects on top of phenylephrine, pushing blood pressure and heart strain higher. Ephedra is the clearest example, while grapefruit works differently, blocking the enzyme that clears dextromethorphan so its levels climb.

Most of the remaining entries, 120 rated moderate, follow related threads. Caffeine, whether from supplements or your morning cup, adds to the stimulant load. Twenty serotonin-active ingredients can intensify dextromethorphan's effects on mood chemistry, and a handful of adsorbent products can pull the medicine out of your gut, so keep those well apart from your dose. Read the seven major entries first; the 22 minor ones matter far less.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 120 Minor 22 No known interaction 1,303

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Brompheniramine, Dextromethorphan, Phenylephrine: Top Interactions at a Glance

The Brompheniramine, Dextromethorphan, Phenylephrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 149 interacting ingredients — plus 1,303 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Brompheniramine, Dextromethorphan, Phenylephrine Combinations Today

The Brompheniramine, Dextromethorphan, Phenylephrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Grapefruit + Brompheniramine, Dextromethorphan, Phenylephrinei

Grapefruit juice can increase blood levels of dextromethorphan, potentially increasing the effects and adverse effects of dextromethorphan.

Read the full interaction Moderate Likelihood Possible English Ivy + Brompheniramine, Dextromethorphan, Phenylephrinei

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Quercetin + Brompheniramine, Dextromethorphan, Phenylephrinei

Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Read the full interaction Minor Likelihood Possible Hibiscus Sabdariffa + Brompheniramine, Dextromethorphan, Phenylephrinei

Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2D6 substrates.

Read the full interaction Moderate Likelihood Possible Fermented Wheat Germ Extract + Brompheniramine, Dextromethorphan, Phenylephrinei

Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Brompheniramine, Dextromethorphan, Phenylephrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Brompheniramine, Dextromethorphan, Phenylephrine

All 1,452 ingredients in our database, ranked by severity — 149 with a Brompheniramine, Dextromethorphan, Phenylephrine interaction on file and 1,303 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Brompheniramine, Dextromethorphan, Phenylephrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Brompheniramine, Dextromethorphan, Phenylephrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase blood levels of dextromethorphan, potentially increasing the effects and adverse effects of dextromethorphan.

Full Grapefruit + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take English Ivy with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Full English Ivy + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Quercetin with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Full Quercetin + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Hibiscus Sabdariffa with Brompheniramine, Dextromethorphan, Phenylephrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2D6 substrates.

Full Hibiscus Sabdariffa + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Fermented Wheat Germ Extract with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse e...

Full Fermented Wheat Germ Extract + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Black Cohosh with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.

Full Black Cohosh + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Black Pepper with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Black Seed with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Boswellia Serrata with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.

Full Boswellia Serrata + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Butcher's Broom with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Cajeput Oil with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.

Full Cajeput Oil + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Calamus with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Cannabidiol (cbd) with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2D6.

Full Cannabidiol (cbd) + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Ceylon Leadwort with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.

Full Ceylon Leadwort + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Chlorella with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Cilantro with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Cinchona with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.

Full Cinchona + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Clove with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.

Full Clove + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Coriander with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.

Full Coriander + Brompheniramine, Dextromethorphan, Phenylephrine answer

Can you take Corydalis Yanhusuo with Brompheniramine, Dextromethorphan, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.

Full Corydalis Yanhusuo + Brompheniramine, Dextromethorphan, Phenylephrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Brompheniramine, Dextromethorphan, Phenylephrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Brompheniramine, Dextromethorphan, Phenylephrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Brompheniramine, Dextromethorphan, Phenylephrine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Brompheniramine, Dextromethorphan, Phenylephrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Brompheniramine, Dextromethorphan, Phenylephrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Brompheniramine, Dextromethorphan, Phenylephrine.

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Products that contain Brompheniramine, Dextromethorphan, Phenylephrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Brompheniramine, Dextromethorphan, Phenylephrine.

Carda Lean by BS Supplements contains Ephedra Lean 40 by First Choice Supplements contains Ephedra Lipodrene with 25 mg Ephedra Extract by Hi-Tech Pharmaceuticals contains Ephedra Stimerex-ES by HTP Hi-Tech Pharmaceuticals contains Ephedra Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Brompheniramine, Dextromethorphan, Phenylephrine & Supplements: Common Questions

What supplements interact with Brompheniramine, Dextromethorphan, Phenylephrine?
In our interaction database, 149 supplement and herbal ingredients have an interaction with Brompheniramine, Dextromethorphan, Phenylephrine on file — 7 rated major, 120 moderate, and 22 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Ephedra, Grapefruit.
Which Brompheniramine, Dextromethorphan, Phenylephrine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Grapefruit, Lithium and Peyote, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Brompheniramine, Dextromethorphan, Phenylephrine?
That depends entirely on which supplement. The honest answer for Brompheniramine, Dextromethorphan, Phenylephrine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Dimetapp DM have the same supplement interactions as Brompheniramine, Dextromethorphan, Phenylephrine?
Yes — Dimetapp DM all contain Brompheniramine, Dextromethorphan, Phenylephrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Brompheniramine, Dextromethorphan, Phenylephrine and my other medications?
This page covers Brompheniramine, Dextromethorphan, Phenylephrine against supplements and herbal ingredients. Checking Brompheniramine, Dextromethorphan, Phenylephrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.