Medication interaction hub

What Supplements Interact with Lansoprazole, Amoxicillin, Clarithromycin?

Lansoprazole, Amoxicillin, Clarithromycin brand name: Prevpac. Every interaction below applies to the brands too.

246 Interactions 14 Major 185 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lansoprazole, Amoxicillin, Clarithromycin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lansoprazole, Amoxicillin, Clarithromycin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prevpac pairs lansoprazole with two antibiotics, amoxicillin and clarithromycin, to knock out an H. pylori stomach infection, and I treat its supplement list with genuine caution. Fourteen of the 246 ingredients on file are rated major; understand those first. Grapefruit can push drug levels up while St. John's wort drags them down, herbs like ephedra can add to clarithromycin's effect on heart rhythm, and alcohol raises the risk of liver damage on top of these drugs.

The 185 moderate and 47 minor entries are mostly quieter versions of the same enzyme and antibiotic themes. Probiotics are a common example; the antibiotics can kill their live organisms, so space those doses well apart. Since Prevpac is usually a 10-to-14-day course, setting nonessential supplements aside until you finish is simpler than vetting each one. Ask your pharmacist about anything you cannot pause, and restart the rest once the infection is cleared.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 185 Minor 47 No known interaction 1,206

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lansoprazole, Amoxicillin, Clarithromycin: Top Interactions at a Glance

The Lansoprazole, Amoxicillin, Clarithromycin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 246 interacting ingredients — plus 1,206 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lansoprazole, Amoxicillin, Clarithromycin Combinations Today

The Lansoprazole, Amoxicillin, Clarithromycin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Lansoprazole, Amoxicillin, Clarithromycini

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Read the full interaction Minor Likelihood Possible Black Psyllium + Lansoprazole, Amoxicillin, Clarithromycini

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Calamus + Lansoprazole, Amoxicillin, Clarithromycini

Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.

Read the full interaction Moderate Likelihood Possible Clove + Lansoprazole, Amoxicillin, Clarithromycini

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Melatonin + Lansoprazole, Amoxicillin, Clarithromycini

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Read the full interaction Minor Likelihood Possible Blessed Thistle + Lansoprazole, Amoxicillin, Clarithromycini

Theoretically, blessed thistle might decrease the effectiveness of PPIs.

Read the full interaction
The complete list

Every Supplement Checked Against Lansoprazole, Amoxicillin, Clarithromycin

All 1,452 ingredients in our database, ranked by severity — 246 with a Lansoprazole, Amoxicillin, Clarithromycin interaction on file and 1,206 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lansoprazole, Amoxicillin, Clarithromycin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Lansoprazole, Amoxicillin, Clarithromycin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Full Betaine Hydrochloride + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Black Psyllium with Lansoprazole, Amoxicillin, Clarithromycin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Calamus with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Clove with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Melatonin with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Full Melatonin + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Grape with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Greater Celandine with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Green Tea with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Green Tea + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Guar Gum with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Hedge Mustard with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hedge mustard with macrolide antibiotics might increase the risk of cardiac glycoside toxicity.

Full Hedge Mustard + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Hemp Agrimony with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Higenamine with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Horny Goat Weed with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Hu Zhang with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.

Full Hu Zhang + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Iboga with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Indian Long Pepper with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take K2/spice with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Kava with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kava might increase levels of CYP2C19 substrates.

Full Kava + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Khella with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Lansoprazole, Amoxicillin, Clarithromycin answer

Can you take Kratom with Lansoprazole, Amoxicillin, Clarithromycin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.

Full Kratom + Lansoprazole, Amoxicillin, Clarithromycin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lansoprazole, Amoxicillin, Clarithromycin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lansoprazole, Amoxicillin, Clarithromycin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lansoprazole, Amoxicillin, Clarithromycin sits in 14 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Proton Pump Inhibitors (Ppis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Amoxicillin (Amoxil, Trimox) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Lansoprazole, Amoxicillin, Clarithromycin through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Lansoprazole, Amoxicillin, Clarithromycin through this category.

Related: does Lansoprazole, Amoxicillin, Clarithromycin deplete any nutrients?

Lansoprazole, Amoxicillin, Clarithromycin has 16 reported nutrient associations in the research literature — see the Lansoprazole, Amoxicillin, Clarithromycin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lansoprazole, Amoxicillin, Clarithromycin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lansoprazole, Amoxicillin, Clarithromycin.

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Pharmacist Counseling Corner

Lansoprazole, Amoxicillin, Clarithromycin & Supplements: Common Questions

What supplements interact with Lansoprazole, Amoxicillin, Clarithromycin?
In our interaction database, 246 supplement and herbal ingredients have an interaction with Lansoprazole, Amoxicillin, Clarithromycin on file — 14 rated major, 185 moderate, and 47 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Khat, Siberian Cocklebur.
Which Lansoprazole, Amoxicillin, Clarithromycin supplement interactions are the most serious?
The 14 major-rated combinations — led by Grapefruit, Khat, Siberian Cocklebur, Activated Charcoal and Arsenic — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lansoprazole, Amoxicillin, Clarithromycin?
That depends entirely on which supplement. The honest answer for Lansoprazole, Amoxicillin, Clarithromycin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Prevpac have the same supplement interactions as Lansoprazole, Amoxicillin, Clarithromycin?
Yes — Prevpac all contain Lansoprazole, Amoxicillin, Clarithromycin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lansoprazole, Amoxicillin, Clarithromycin deplete any vitamins or nutrients?
It might — Lansoprazole, Amoxicillin, Clarithromycin has 16 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lansoprazole, Amoxicillin, Clarithromycin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lansoprazole, Amoxicillin, Clarithromycin and my other medications?
This page covers Lansoprazole, Amoxicillin, Clarithromycin against supplements and herbal ingredients. Checking Lansoprazole, Amoxicillin, Clarithromycin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.