Medication interaction hub

What Supplements Interact with Miglitol?

Miglitol brand name: Glyset. Every interaction below applies to the brands too.

256 Interactions 2 Major 215 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Miglitol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Miglitol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Siberian cocklebur is the interaction to understand first with miglitol (Glyset), a diabetes medicine that slows carbohydrate absorption after meals. Its seeds have caused severe hypoglycemia in people, and it should not be combined with any glucose-lowering drug. That risk sets the tone for a list worth real care, since 239 of the 256 ingredients here touch blood sugar directly. Most add to miglitol's glucose-lowering effect, while a handful, niacin among them, push sugar up and blunt the drug instead.

The other major entry is activated charcoal, which soaks up oral medicines and cuts their absorption; 17 ingredients act on absorption this way, so keep them well apart from your dose. Beyond the two majors, 215 entries rate moderate and 39 minor, and because miglitol's whole purpose is steadying blood sugar, even the moderate additive effects deserve closer glucose checks whenever a supplement is added.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 215 Minor 39 No known interaction 1,196

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Miglitol: Top Interactions at a Glance

The Miglitol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 256 interacting ingredients — plus 1,196 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Miglitol Combinations Today

The Miglitol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Apple Cider Vinegar + Miglitoli

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ba Ji Tian + Miglitoli

Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Read the full interaction Moderate Likelihood Possible Madagascar Periwinkle + Miglitoli

Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.

Read the full interaction Moderate Likelihood Possible Chirata + Miglitoli

Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Quassia + Miglitoli

In animals, quassia extract reduced levels of fasting glucose.

Read the full interaction Moderate Likelihood Possible Shilajit + Miglitoli

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Miglitol

All 1,452 ingredients in our database, ranked by severity — 256 with a Miglitol interaction on file and 1,196 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Miglitol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple Cider Vinegar with Miglitol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Miglitol answer

Can you take Ba Ji Tian with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Full Ba Ji Tian + Miglitol answer

Can you take Madagascar Periwinkle with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.

Full Madagascar Periwinkle + Miglitol answer

Can you take Chirata with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Miglitol answer

Can you take Quassia with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, quassia extract reduced levels of fasting glucose.

Full Quassia + Miglitol answer

Can you take Banaba with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Miglitol answer

Can you take Beer with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Beer + Miglitol answer

Can you take Bitter Melon with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Miglitol answer

Can you take Branched-chain Amino Acids (bcaa) with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BCAAs might alter the effects of antidiabetes medications.

Full Branched-chain Amino Acids (bcaa) + Miglitol answer

Can you take Coffee Charcoal with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Miglitol answer

Can you take Cumin with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Miglitol answer

Can you take Ephedra with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Miglitol answer

Can you take European Mandrake with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Miglitol answer

Can you take Fenugreek with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Full Fenugreek + Miglitol answer

Can you take Fig with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.

Full Fig + Miglitol answer

Can you take Flaxseed with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.

Full Flaxseed + Miglitol answer

Can you take Glucomannan with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Miglitol answer

Can you take Gymnema with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.

Full Gymnema + Miglitol answer

Can you take Inositol Nicotinate with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Inositol Nicotinate + Miglitol answer

Can you take Ivy Gourd with Miglitol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Ivy Gourd + Miglitol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Miglitol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Miglitol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Miglitol sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Miglitol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Miglitol through this category.

About Miglitol

Miglitol is an oral diabetes medication used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Generic name: Miglitol  ·  Brand name: Glyset.

See the full Miglitol drug information

Related: does Miglitol deplete any nutrients?

Miglitol has 1 reported nutrient association in the research literature — see the Miglitol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Miglitol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Miglitol.

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Pharmacist Counseling Corner

Miglitol & Supplements: Common Questions

What supplements interact with Miglitol?
More than you might expect — 256 in total, though they are far from equal: 2 are rated major, 215 moderate, and 39 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Miglitol supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Miglitol?
Usually yes — most people on Miglitol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Glyset have the same supplement interactions as Miglitol?
Yes — Glyset all contain Miglitol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Miglitol deplete any vitamins or nutrients?
It might — Miglitol has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Miglitol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Miglitol and my other medications?
This page covers Miglitol against supplements and herbal ingredients. Checking Miglitol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Miglitol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.