Medication interaction hub

What Supplements Interact with Tisotumab Vedotin-Tftv?

Tisotumab Vedotin-Tftv brand name: Tivdak. Every interaction below applies to the brands too.

121 Interactions 2 Major 87 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tisotumab Vedotin-Tftv? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tisotumab Vedotin-Tftv against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you are receiving tisotumab vedotin (Tivdak), an infusion used to treat cervical cancer, treat this page with real care and clear every supplement with your oncology team first. All 121 ingredients here act through the same liver enzyme, CYP3A4, which processes the chemotherapy portion of this drug. Grapefruit blocks that enzyme and can push drug levels up, raising the risk of side effects, while St. John's wort speeds the drug's breakdown and could weaken a treatment you cannot afford to weaken. Those two carry the major ratings, and they are the ones to understand first.

The remaining 119 split into 87 moderate and 32 minor entries, most supported by lab research rather than human studies. Some nudge drug levels up, others down, and with chemotherapy either direction matters. Skipping grapefruit entirely and stopping St. John's wort removes the two biggest risks on this list.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 87 Minor 32 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Tisotumab Vedotin-Tftv: Top Interactions at a Glance

The most significant Tisotumab Vedotin-Tftv supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Tisotumab Vedotin-Tftv + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Tisotumab Vedotin-Tftvi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable St. John's Wort + Tisotumab Vedotin-Tftvi

St.

Read the full interaction
The complete list

Every Supplement Checked Against Tisotumab Vedotin-Tftv

All 1,452 ingredients in our database, ranked by severity — 121 with a Tisotumab Vedotin-Tftv interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tisotumab Vedotin-Tftv?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hibiscus Sabdariffa with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Tisotumab Vedotin-Tftv answer

Can you take Honey with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Tisotumab Vedotin-Tftv answer

Can you take Hops with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Tisotumab Vedotin-Tftv answer

Can you take Melatonin with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Tisotumab Vedotin-Tftv answer

Can you take Passion Flower with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Tisotumab Vedotin-Tftv answer

Can you take Puravive with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Tisotumab Vedotin-Tftv answer

Can you take Rhodiola with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Tisotumab Vedotin-Tftv answer

Can you take Valerian with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Tisotumab Vedotin-Tftv answer

Can you take Vitamin D with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Tisotumab Vedotin-Tftv answer

Can you take Yerba Mate with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Tisotumab Vedotin-Tftv answer

Can you take Yohimbe with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Tisotumab Vedotin-Tftv answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Tisotumab Vedotin-Tftv answer

Can you take Eleuthero with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Tisotumab Vedotin-Tftv answer

Can you take Green Tea with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Tisotumab Vedotin-Tftv answer

Can you take Gymnema with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Tisotumab Vedotin-Tftv answer

Can you take Humann Superbeets Heart Chews with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Tisotumab Vedotin-Tftv answer

Can you take Jequirity with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Tisotumab Vedotin-Tftv answer

Can you take Kava with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Tisotumab Vedotin-Tftv answer

Can you take Milk Thistle with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Tisotumab Vedotin-Tftv answer

Can you take Mommy's Bliss Gripe Water with Tisotumab Vedotin-Tftv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Tisotumab Vedotin-Tftv answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tisotumab Vedotin-Tftv is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tisotumab Vedotin-Tftv, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tisotumab Vedotin-Tftv sits in 1 interaction category. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Tisotumab Vedotin-Tftv through this category.

About Tisotumab Vedotin-Tftv

Tisotumab Vedotin-Tftv is a prescription medication also sold under the brand name Tivdak. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Tisotumab Vedotin-Tftv  ·  Brand name: Tivdak.

See the full Tisotumab vedotin-tftv drug information
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Take a Supplement Product? Check the Whole Bottle Against Tisotumab Vedotin-Tftv

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tisotumab Vedotin-Tftv.

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Pharmacist Counseling Corner

Tisotumab Vedotin-Tftv & Supplements: Common Questions

What supplements interact with Tisotumab Vedotin-Tftv?
Our database currently documents 121 ingredients with a known Tisotumab Vedotin-Tftv interaction (2 major, 87 moderate, 32 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 121. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Tisotumab Vedotin-Tftv supplement interactions are the most serious?
Focus on the major group: Grapefruit and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tisotumab Vedotin-Tftv?
Plenty of supplements coexist fine with Tisotumab Vedotin-Tftv; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tivdak have the same supplement interactions as Tisotumab Vedotin-Tftv?
Yes — Tivdak all contain Tisotumab Vedotin-Tftv, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tisotumab Vedotin-Tftv and my other medications?
This page covers Tisotumab Vedotin-Tftv against supplements and herbal ingredients. Checking Tisotumab Vedotin-Tftv against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tisotumab vedotin-tftv drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.