Formula 594 Ingredients & Drug Interactions
by DC
What is this page for?
First and foremost: checking Formula 594 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Formula 594 is a dietary supplement by DC with 4 active ingredients. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 1,116 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Horny Goat Weed, Mucuna pruriens. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Formula 594 by DC
Ask about any prescription or over-the-counter medication and we check it for interactions with Formula 594 by DC — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Formula 594 by DC
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Formula 594 contains four active ingredients. Horny Goat Weed and Maca are plant extracts traditionally used to address sexual function and general wellness, though the evidence supporting them is not yet well established.
Mucuna pruriens (also called cowhage) is a legume extract that contains levodopa, an active drug-like compound normally prescribed for Parkinson's disease — it's included here because of its role in dopamine support. We could not verify the interaction profile of Polypodium vulgare extract.
The capsules also contain inactive ingredients (gelatin, vegetable cellulose, vegetable magnesium stearate, and silica) that serve as fillers and binders.
Does it work?
Insufficient evidence
The evidence supporting Formula 594's active ingredients is not well established. Horny Goat Weed has been studied for sexual dysfunction, bronchitis, osteoporosis, and coronary heart disease, but we do not have reliable evidence to rate its effectiveness for any of these uses.
Maca has been studied for sexual function issues, low iron (anemia of chronic disease), athletic performance, and osteoporosis — again, the evidence is insufficient to establish whether it works. Mucuna pruriens has been studied for anxiety, Parkinson's disease, high prolactin levels, and other conditions, but reliable evidence is not available.
Because the evidence is not yet established in our data, talk with your pharmacist or doctor about whether this product matches your health goals.
How safe is it?
Well-documented data
Horny Goat Weed is generally well tolerated in short-term use, though side effects including dizziness, dry mouth, nosebleed, thirst, and vomiting have been reported. One rare case of respiratory arrest and another of heart rhythm problems were reported; quality and contents vary between products.
The safety data advises against use during pregnancy and while breastfeeding. Maca is generally well tolerated as a food, but long-term safety as a supplement has not been studied.
Fresh uncooked maca may cause stomach pain. Safety data is insufficient during pregnancy and breastfeeding.
Mucuna pruriens contains levodopa and should be used carefully with professional guidance. Most common side effects are diarrhea, flatulence, and mouth irritation when taken orally.
Nausea, abdominal bloating, and vomiting have been reported in clinical research at higher doses. Headaches and insomnia (in about 3% of patients at higher doses) have also been reported.
The safety data advises against use during pregnancy because of its dopamine effects, and against breastfeeding because levodopa can lower prolactin and reduce milk supply.
Meds to double-check
Major interaction found
Before taking Formula 594, check with your pharmacist if you take methyldopa or any MAOI (an older class of antidepressant), or if you're already taking levodopa for any reason — these are Major-severity interactions. Also double-check if you take blood pressure medications, blood thinners or antiplatelet drugs, estrogen-based medications including birth control, diabetes drugs, antipsychotics, older-style antidepressants called tricyclic antidepressants, guanethidine, or drugs that are processed through your liver (many common medications are).
If you're scheduled for surgery and will receive anesthesia, let your anesthesiologist know you're taking this product.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Formula 594 is a four-ingredient supplement with major interactions involving certain blood pressure drugs, antidepressants, and anesthetics — chiefly because of its Mucuna pruriens content. If you take any prescription medication or have cardiovascular or mood disorders, check your exact drugs with the tool on this page before starting.
This product is not recommended during pregnancy or breastfeeding. Talk with your pharmacist before use to make sure it's appropriate for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Formula 594, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Formula 594 by DC, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Horny Goat Weed | 500 mg | -- |
| Maca | 250 mg | -- |
| Mucuna pruriens | 33.4 mg | -- |
| Polypodium vulgare ext. | 25 mg | -- |
Other ingredients: Gelatin, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 2 capsules daily with a meal. For a more immediate response take 3 to 4 capsules 90 minutes before activity.
Precautions
Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children.
Caution: If you are pregnant or nursing do not take this product.
Formulation
Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Gluten free
Dynamic complex
Made in USA
Storage
Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).
Seals/Symbols
Quali Pure
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Formula 594 by DC label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Formula 594 by DC
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Horny Goat Weed
Interacts with963 drugs
Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...
Horny Goat Weed monograph & interactionsMaca
No knowninteractions
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...
Maca monograph & interactionsMucuna pruriens
Interacts with193 drugs
Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...
Mucuna pruriens monograph & interactionsPolypodium vulgare ext.
Other (inactive) ingredients: Gelatin, Vegetable Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Formula 594 by DC Drug Interactions
HelloPharmacist Interaction Report
Formula 594 by DC contains multiple ingredients with documented interactions with medications.
The most serious concern is Mucuna pruriens (cowhage), which contains levodopa and carries Major-severity interactions with methyldopa (a blood pressure drug), MAOIs (a class of antidepressants), and levodopa itself — these combinations risk dangerously low or high blood pressure, hypertensive crisis, or severe levodopa side effects.
Read the full breakdown — every affected drug type, severity by severity
Horny Goat Weed has Moderate interactions with several drug classes: blood pressure medications (risk of drops in blood pressure), blood thinners and antiplatelet drugs (increased bleeding risk), estrogen-containing medications including birth control (increased hormone effects), and drugs processed by your liver's CYP1A2, CYP2B6, and CYP3A4 pathways (which metabolize a broad range of common medications, from certain heart drugs to some statins and immunosuppressants).
Mucuna pruriens also carries Moderate interactions with diabetes medications (risk of low blood sugar), antipsychotics (reduced effectiveness), older-style antidepressants called tricyclic antidepressants (reduced effectiveness and possible high blood pressure or involuntary movements), and certain anesthetics (risk of irregular heartbeat). Guanethidine, an older blood pressure drug, also interacts at Moderate severity.
We could not check Polypodium vulgare extract for interactions — no data is on file for it. Maca has no interactions documented in our data.
Altogether, these interactions span 1,104 individual medications. Please use the medication checker below with your exact prescriptions and over-the-counter drugs before taking this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Formula 594?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Formula 594 interact with 1,116 drugs. Click any drug to see the details.
2 of the 4 ingredients in Formula 594 interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Mucuna pruriens
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Amphetamine interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Formula 594 — through 2 ingredients. Tap an ingredient for the detail:
Mucuna PruriensMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens + Chlorothiazide, Methyldopa interactionHorny Goat WeedAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed + Chlorothiazide, Methyldopa interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Formula 594 — through 2 ingredients. Tap an ingredient for the detail:
Mucuna PruriensMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens + Hydrochlorothiazide, Methyldopa interactionHorny Goat WeedAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed + Hydrochlorothiazide, Methyldopa interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Isocarboxazid interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens + Levodopa, Carbidopa interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with Formula 594 — through 2 ingredients. Tap an ingredient for the detail:
Mucuna PruriensMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens + Methyldopa interactionHorny Goat WeedAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed + Methyldopa interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Formula 594 — through 2 ingredients. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Rasagiline interactionHorny Goat WeedCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens + Tranylcypromine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Mucuna PruriensAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Formula 594 — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat WeedCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Acetaminophen, Aspirin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Formula 594 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Horny Goat Weed
Anticoagulant/Antiplatelet Drugs
Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.
Antihypertensive Drugs
Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.
Mucuna pruriens
Levodopa
Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.
Methyldopa (Aldomet)
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.
Anesthesia
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
Antidiabetes Drugs
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.
Antipsychotic Drugs
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.
Guanethidine (Ismelin)
Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.
Tricyclic Antidepressants (Tcas)
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.
Brand information
Manufacturer and brand details for Formula 594, from the product label.
DC
See all DC products- Name
- Dee Cee Laboratories, Inc.
- Street Address
- 304 Dee Cee Rd.
- City
- White House
- State
- TN
- ZipCode
- 37188
Formula 594 by DC: Common Questions
Does Formula 594 by DC interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Formula 594 if I'm pregnant?
Can I take it while breastfeeding?
What is levodopa, and why is it in this product?
What are the most common side effects?
Does this product actually work for sexual dysfunction?
Why does the product label say it interacts with over 1,000 medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Formula 594 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Formula 594’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Horny Goat Weed
Interacts with 963 drugsHorny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...
Read the full Horny Goat Weed monograph → Herb & supplement monographMaca
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...
Read the full Maca monograph → Herb & supplement monographCowhage
Interacts with 193 drugsCowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...
Read the full Cowhage monograph →Sources & How We Checked
Formula 594's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Horny Goat Weed 11 references
- Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
- Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
- De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
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