Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PS Brain Support Ingredients & Drug Interactions

by Purity Products

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

PS Brain Support is a dietary supplement by Purity Products with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sharp-PS Green Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of PS Brain Support by Purity Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PS Brain Support contains one active ingredient: Sharp-PS Green Phosphatidylserine. Phosphatidylserine is a naturally occurring compound that plays a role in cell membrane structure and is thought to support brain function.

The product also includes sunflower oil and a soft gelatin capsule as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy brain function and cell communication.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), memory, mental performance, focus.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease, based on the data we hold. For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't established enough to rate.

The ingredient's benefits for thinking and memory aren't fully proven across all conditions.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with insomnia more likely at higher doses (600 mg) and stomach upset possible at 200–300 mg daily.

Do not use this product during pregnancy — there isn't enough safety information. Safety while breastfeeding is also unknown, so avoidance is recommended.

Talk with your doctor or pharmacist about your specific situation before taking it if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use anticholinergic drugs (medications that block acetylcholine activity, used for conditions like overactive bladder or certain types of tremor) or cholinergic drugs (medications that increase acetylcholine activity). Both categories have moderate-severity theoretical interactions with phosphatidylserine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PS Brain Support may be worth considering if you're concerned about age-related memory loss or Alzheimer disease, though the evidence is modest. If you take anticholinergic or cholinergic medications, check your exact drugs with your doctor or pharmacist before starting — this supplement could theoretically interfere with how they work.

Avoid it during pregnancy and breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS Brain Support, straight from the product label.

Brand Purity Products
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244093
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS Brain Support by Purity Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Sharp-PS Green Phosphatidylserine100 mg--

Other ingredients: Soft Gelatin Capsule, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Intelligent nutritional solutions

Premium grade supplements Since 1993

Formula

100mg of sharp-PS green phosphatidylserine

Formulation

Supports healthy brain function Supports brain cell communication

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take one capsule daily with a meal. For daily use.

Brand IP Statement(s)

Sharp-PS is a registered trademark of Enzymotec Ltd. Sharp-PS Green

See for yourself

PS Brain Support by Purity Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in PS Brain Support by Purity Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Sharp-PS Green Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Sunflower

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Soft Gelatin Capsule, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS Brain Support by Purity Products Drug Interactions

Want to check YOUR meds against PS Brain Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in PS Brain Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sharp-PS Green Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for PS Brain Support, from the product label.

Purity Products

See all Purity Products products
Name
Purity Products
Pharmacist Counseling Corner

PS Brain Support by Purity Products: Common Questions

Does PS Brain Support by Purity Products interact with any medications?
Yes. Based on its ingredients, PS Brain Support has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS Brain Support contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine actually do?
Phosphatidylserine is a compound that's part of cell membranes and is thought to support brain function. The data we hold shows it's possibly effective for age-related cognitive decline and Alzheimer disease, but for other uses like ADHD or general memory, the evidence isn't strong enough to say whether it works.
What are the common side effects?
Most people tolerate it well, but you might experience flatulence, nausea, gastrointestinal upset, headache, or insomnia. Insomnia is more likely if you take a higher dose (600 mg), and stomach upset can show up at doses of 200–300 mg daily.
Is it safe during pregnancy or breastfeeding?
No — there isn't enough safety information for pregnancy, so it should be avoided. Safety while breastfeeding is also unknown, so avoidance is recommended. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding.
How long does it take to work?
The product facts don't specify a timeline for effectiveness. That's a good question for your pharmacist or doctor, who can tell you what to expect based on the research.
Is there anything else in this supplement besides phosphatidylserine?
The active ingredient is phosphatidylserine. The capsule also contains sunflower oil and soft gelatin as inactive ingredients — those are just there to hold and deliver the active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS Brain Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS Brain Support label
Sources

Sources & How We Checked

PS Brain Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring