Bacopa + Amitriptyline, Chlordiazepoxide
Amitriptyline, Chlordiazepoxide brand name: Limbitrol DS.
Amitriptyline, Chlordiazepoxide falls into 5 drug categories that Bacopa can interact with; the most serious is rated moderate. Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full interaction reportBacopa and Amitriptyline, Chlordiazepoxide
These two interact in 5 distinct ways. Each one is explained separately below.
Why Are There 5 Interactions?
Bacopa interacts with whole categories of medication. Amitriptyline, Chlordiazepoxide falls into 5 of those categories, so it can interact with Bacopa in 5 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 5Why this applies to Amitriptyline, Chlordiazepoxide
Amitriptyline, Chlordiazepoxide falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Bacopa interacts with.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (an older antidepressant) with chlordiazepoxide (a benzodiazepine that calms anxiety). The amitriptyline part is partly handled by a liver enzyme called CYP1A2. In test-tube studies, bacopa may slow that enzyme down a little, which could in theory let amitriptyline build up slightly in your body.
If that happened, you might notice more of this medicine's usual effects, like drowsiness, dry mouth, constipation, blurred vision, or feeling lightheaded when standing. That said, this is only a theoretical concern from lab work, and the research is mixed, so the real-world effect may be small or none. Still, since both drugs already cause sleepiness, I'd run any bacopa supplement past your pharmacist or doctor first.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
2 of 5Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (an older antidepressant) with chlordiazepoxide (a benzodiazepine for anxiety). Both rely partly on a liver enzyme called CYP2C19 to be broken down. In lab dish studies, bacopa appears to slow this enzyme down a bit. The concern is that, in theory, this could let these two medicines build up in your system more than expected.
If that happened, you might notice stronger versions of their usual effects: more drowsiness, dizziness, dry mouth, constipation, blurry vision, or feeling extra groggy and unsteady. I want to stress that this is only a theoretical worry based on test-tube data, not real patient cases, so it may not matter at all. Still, since both drugs are sedating, it is worth running this combination by your pharmacist or doctor before adding bacopa.
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 5Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. Limbitrol combines amitriptyline (an older antidepressant) with chlordiazepoxide (a sedative). The concern on file is that bacopa might slow down one of the liver enzymes (CYP2C9) that helps clear these medicines. If that happened, the drug could build up a bit in your body, which could mean stronger effects like drowsiness, dizziness, dry mouth, constipation, or trouble thinking clearly.
That said, I want to keep this in perspective. This is only a theoretical worry from lab studies, and the lab results actually disagree with each other. We don't have real-world cases showing a problem. Still, since both of these medicines already cause sleepiness, it's worth a quick chat with your pharmacist or doctor before you add bacopa.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
4 of 5Amitriptyline, Chlordiazepoxide also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Limbitrol DS combines amitriptyline (an older antidepressant) with chlordiazepoxide (a benzodiazepine for anxiety). Both rely partly on a liver enzyme called CYP3A4 to be cleared from your body. The thinking here is that bacopa might slow that enzyme down a little. If it does, these medicines could linger longer and feel stronger than usual.
In real life that might show up as extra drowsiness, dizziness, dry mouth, constipation, blurry vision, or feeling foggy. Here is the honest part: this concern comes only from lab and test-tube studies, and even those results disagree. So it is more of a theoretical caution than a proven problem. Still, since both drugs already cause sedation, it is worth mentioning bacopa to your pharmacist or doctor before combining them.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
ANTICHOLINERGIC DRUGS
5 of 5Amitriptyline, Chlordiazepoxide also falls under ANTICHOLINERGIC DRUGS.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Limbitrol DS, which pairs amitriptyline (an older antidepressant) with chlordiazepoxide (a benzodiazepine). The amitriptyline part has strong anticholinergic activity, meaning it blocks the brain messenger acetylcholine. Bacopa is thought to do the opposite in lab studies, nudging acetylcholine levels up. So in theory the two could tug against each other, slightly blunting what each is trying to do.
I want to be honest: this is theoretical, based on how these things work in the lab, not on real patient reports. In practice it's unlikely to cause a dramatic problem. Still, since you'd hate to lose mood or sleep benefit, run it past your pharmacist or doctor before adding bacopa.
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Bacopa Also Interacts With Other Medications
Bacopa has 916 moderate, 13 minor known drug interactions in our database — the Amitriptyline, Chlordiazepoxide one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bacopa
We haven’t checked that one against Bacopa yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bacopa. Pick one to open its full report.
See Every Supplement That Interacts With Amitriptyline, Chlordiazepoxide
This page covers Bacopa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline, Chlordiazepoxide page lists 298 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).
By severity: 17 major · 231 moderate · 50 minor.
From our pharmacist’s overview on the Amitriptyline, Chlordiazepoxide page
“Alcohol is the first thing to know about here. Beer and wine both carry major, well-documented interactions with Amitriptyline and Chlordiazepoxide (Limbitrol DS), because both drugs already slow the central nervous system, and anything sedating layered on top can deepen ordinary drowsiness into something dangerous.”
Reviewed by 2 · Jul 18, 2026
Taking Bacopa as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,420 real supplement products containing Bacopa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bacopa. Your product may carry other ingredients that interact with Amitriptyline, Chlordiazepoxide too, on top of Bacopa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Bacopa and Amitriptyline, Chlordiazepoxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#136 of 1,452 supplements looked up here in the last 7 days
#1,738 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Bacopa
What is Bacopa?
- Memory and cognitive support
- Anxiety and stress
- ADHD symptoms
- Age-related memory decline
- General brain health
Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limited and quality varies. It is generally well tolerated but can cause stomach upset, and it should be avoided in pregnancy and breastfeeding due to a lack of safety data.
Other Drugs & Bacopa
Browse every other medication we’ve checked against Bacopa — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
916 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Glycopyrrolate ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Ipratropium ›
- Miconazole ›
- Procainamide ›
- Trimipramine ›
- Acetaminophen ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Dimenhydrinate ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Meloxicam ›
- Nortriptyline ›
- Pilocarpine ›
- Procyclidine ›
- Rifampin ›
Showing 60 of 916 moderate interactions — see all 916 on the Bacopa page.
13 interactions
No interaction 1,900 drugs checked — show the list
We also checked Bacopa against these medications and found no known interaction in our sources. Open any page to confirm.
- Methylphenidate ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Duloxetine ›
- Ciprofloxacin ›
- Bisoprolol ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levetiracetam ›
- Dexmethylphenidate ›
- Spironolactone ›
- Factor 7a ›
- Carbidopa, Levodopa ›
- Minoxidil ›
- Mitomycin ›
- Levodopa ›
- Ezetimibe ›
- Cefaclor ›
- Venlafaxine ›
- Lenvatinib ›
- Vancomycin ›
- Phenylephrine ›
- Hethylphenidate Hcl ›
- Phentermine, Topiramate ›
- Bentoquatam ›
- Dirithromycin ›
- Codeine Sulfate ›
Showing the 60 most looked-up of 1,900 medications checked with no known interaction — see the full Bacopa list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Amitriptyline, Chlordiazepoxide Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Amitriptyline, Chlordiazepoxide as a medicine that can lower these. This is not an interaction with Bacopa — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Amitriptyline, Chlordiazepoxide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Bacopa and Amitriptyline, Chlordiazepoxide Together: Common Questions
Can you take Bacopa with Amitriptyline, Chlordiazepoxide?
Why are there 5 interactions listed for Bacopa and Amitriptyline, Chlordiazepoxide?
How serious is the Bacopa and Amitriptyline, Chlordiazepoxide interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Amitriptyline, Chlordiazepoxide and Bacopa?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.