Drug & supplement interaction

Green Coffee + Selinexor

Selinexor brand name: Xpovio.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Green Coffee and Selinexor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Green Coffee and Selinexor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Selinexor and Green Coffee in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Green Coffee safety at a glance

Green Coffee overall Use caution Generally well tolerated in food amounts, but supplements contain caffeine and may cause stimulant-related effects.
Pregnancy Use caution Limit caffeine during pregnancy; concentrated supplement amounts are not well studied, so it is best to avoid them.
Breastfeeding Use caution Caffeine passes into breast milk; avoid concentrated supplements and limit intake.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Selinexor and Green Coffee? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Selinexor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Selinexor is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Green Coffee has documented interactions with 31 drug classes — the most serious being ephedrine (major), adenosine (adenocard) (moderate) and alendronate (fosamax) (moderate) — and none of Selinexor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Green Coffee Does Interact With Other Medications

Green Coffee has 8 major, 442 moderate, 222 minor known drug interactions in our database — Selinexor isn’t one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 442 Minor 222 No known interaction 2,158 (incl. Selinexor)
Taking anything else?

Check Another of Your Medications Against Green Coffee

Covers the 2,830 medications we’ve checked against Green Coffee. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Green Coffee and Selinexor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tiredness reported in 33.3% of FDA reports for Selinexor Additional detail

    Green Coffee

    “Chronic use of caffeine, especially in large amounts, may produce tolerance, habituation, and psychological dependence. Abrupt discontinuation of caffeine may result in physical withdrawal symptoms, including headache, fatigue, drowsiness, decreased physical energy, difficulty concentrating, depression, anxiety, irritability, and reduced alertness.”

    Green Coffee · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 3719. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
    2. 13738. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. PubMed
    3. 13736. Anderson BJ, Gunn TR, Holford NH, Johnson R. Caffeine overdose in a premature infant: clinical course and pharmacokinetics. Anaesth Intensive Care 1999;27:307-11. PubMed

    Selinexor

    Listed in the ADVERSE REACTIONS section of the FDA label for Selinexor, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A stuffy or runny nose Additional detail

    Green Coffee

    “Occupational exposure to green coffee beans has been documented to cause numerous adverse respiratory reactions, including bronchial reactivity, asthma, and rhinitis. Healthy subjects exposed experimentally to green coffee dust displayed acute decreases in expiratory flow rates. In one study, green coffee workers displayed numerous acute respiratory symptoms when exposed to dust;”

    Green Coffee · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 53589. Glauser, T., Bircher, A., and Wuthrich, B. [Allergic rhinoconjunctivitis caused by the dust of green coffee beans]. Schweiz.Med.Wochenschr. 8-29-1992;122(35):1279-1281.
    2. 53641. Thomas, K. E., Trigg, C. J., Baxter, P. J., Topping, M., Lacey, J., Crook, B., Whitehead, P., Bennett, J. B., and Davies, R. J. Factors relating to the development of respiratory symptoms in coffee process workers. Br.J.Ind.Med. 1991;48(5):314-322. PubMed
    3. 53644. Zuskin, E., Kanceljak, B., Mataija, M., and Tonkovic-Lojovic, M. [Specific bronchial reactivity in unripe coffee processing workers]. Arh.Hig.Rada Toksikol. 1989;40(1):3-8.
    4. 53648. Johansen, J. P. and Viskum, S. [Asthma associated with the handling of green coffee beans]. Ugeskr.Laeger 10-12-1987;149(42):2853.
    5. 53650. Zuskin, E., Dreshaj, I., Jakupi, M., and Haxhiu, M. A. Effect of exposure to green coffee dust extract on airway reactivity. Arh.Hig.Rada Toksikol. 1986;37(2):205-216.
    6. 53665. Mairesse, M., Casel, S., and Ledent, C. [Asthma to green coffee of environmental origin]. Rev.Mal Respir. 1996;13(3):308-309.

    Selinexor

    Listed in the ADVERSE REACTIONS section of the FDA label for Selinexor. Read the label on DailyMed ›

Reported for Green Coffee but not commonly for Selinexor: trouble concentrating, dependence or withdrawal symptoms, raised blood pressure and mood changes or irritability.

Effects for Selinexor come from the ADVERSE REACTIONS section of its FDA label; effects for Green Coffee come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,359 voluntary FDA FAERS reports for Selinexor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Selinexor

This page covers Green Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selinexor page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Selinexor page

“Selinexor (Xpovio) treats multiple myeloma and certain lymphomas, and its side effects are rough enough at intended doses that any shift in its blood level deserves genuine caution. Almost all of the 138 supplements and herbs listed here, 121 of them, can change how a liver enzyme called CYP3A4 handles the drug, pushing its level up or…”

Reviewed by 2 · Jul 18, 2026

Open the Selinexor interaction page

One more smart check

Taking Green Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,716 real supplement products containing Green Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Green Coffee. Even though Green Coffee itself has no known interaction with Selinexor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Green Coffee and Selinexor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Green Coffee
Top half

#572 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selinexor
Top 25%

#572 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Green Coffee reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Green Coffee and Selinexor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Green Coffee

What is Green Coffee?

Green Coffee
  • Weight loss
  • High blood pressure
  • Blood sugar control
  • Antioxidant support
  • General energy

Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content. Some early studies suggest modest benefits for weight, blood pressure, and blood sugar, but the evidence is limited and far from conclusive. It contains caffeine, so people sensitive to stimulants should use caution and check with a pharmacist or doctor first.

Coffea arabica · Rubiaceae · Raw (unroasted) coffee beans (seeds) · Capsules, tablets, powders, extracts, and brewed beverages

An interaction check asks whether these two react with each other — it does not ask whether Green Coffee is a good idea for someone in your situation. Here is what our Green Coffee record says about it on its own.

Green Coffee: dosing

There is no official, standardized dose for green coffee. Products vary widely in how much chlorogenic acid and caffeine they contain, which makes comparing them difficult.The best approach is to follow the directions on the product label and not exceed the recommended amount. Because green coffee contains caffeine, count it toward your total daily caffeine intake from all sources.

From our Green Coffee monograph — the full record covers uses, side effects and every documented interaction.

Read the full Green Coffee monograph & all interactions
Medication

About Selinexor

What Is Selinexor Used For?

Brand name: Xpovio

Xpovio (selinexor) is used to treat multiple myeloma in adults. When used together with bortezomib and dexamethasone, it is for adults who have had at least one prior treatment. This combination is sometimes called XVd.

Xpovio is also used with dexamethasone alone (called Xd) for adults with relapsed or refractory multiple myeloma — meaning the cancer came back or stopped responding — who have already tried at least four prior therapies and whose disease no longer responds to several other standard drug types.

See full Selinexor drug information
Keep checking

Other Drugs & Green Coffee

Browse every other medication we’ve checked against Green Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
442Moderate
222Minor
2,157No known interaction
8 Major 442 Moderate 222 Minor 2,157 No interaction
Major

8 interactions

Moderate

442 interactions

Showing 60 of 442 moderate interactions — see all 442 on the Green Coffee page.

Minor

222 interactions

Showing 60 of 222 minor interactions — see all 222 on the Green Coffee page.

No interaction 2,157 drugs checked — show the list

We also checked Green Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,157 medications checked with no known interaction — see the full Green Coffee list.

See the full Green Coffee interactions page
See every supplement checked against Selinexor, ranked by severity
Evidence & sources

Green Coffee References

The 103 references that drive our Green Coffee monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  8. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  9. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  10. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  11. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  12. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  13. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
  14. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
  15. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Green Coffee and Selinexor Together: Common Questions

Is it safe to take Green Coffee with Selinexor?
We do not list a known interaction between Green Coffee and Selinexor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Green Coffee and Selinexor have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Green Coffee and Selinexor combination checked?
Interactions in our licensed database are recorded against drug classes. Selinexor is filed under 2 classifications, and Green Coffee has documented interactions with 31 drug classes — none of Selinexor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Green Coffee interact with any other medications?
Yes. Green Coffee has 672 documented drug interactions in our database — Selinexor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Selinexor interact with any supplements?
Yes. Selinexor has documented interactions with 138 supplements in our database — Green Coffee is not one of them. The Selinexor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Green Coffee monograph Uses, safety profile, and every drug interaction in one place Selinexor drug information The full plain-English guide to this medication Selinexor supplement interactions Every supplement checked against Selinexor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 103 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Selinexor and Green Coffee?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.