Herb & supplement monograph

Chrysin Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Chrysin interacts with medications. The heart of this page is the interaction list — every drug Chrysin is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Chrysin is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Chrysin

358 medications have a known interaction with Chrysin, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Chrysin using our pharmacist-reviewed interaction data.

AI summaries are generated from our Chrysin interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Chrysin combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Chrysin affects

Every type of medication (drug category) Chrysin is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 9 drug categories Chrysin interacts with

Anticoagulant/antiplatelet DrugsAromatase InhibitorsContraceptive DrugsDiclofenac (voltaren, Others)EstrogensMephenytoin (mesantoin)Cytochrome P450 1a2 (cyp1a2) SubstratesGlucuronidated DrugsTestosterone

Anticoagulant/Antiplatelet Drugs

Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that chrysin might inhibit platelet aggregation.

Likelihood Possible Evidence D

Aromatase Inhibitors

Theoretically, chrysin might increase the effects and adverse effects of aromatase inhibitors.
In vitro research suggests that chrysin might decrease estrogen synthesis by acting as an aromatase (estrogen synthetase) inhibitor..

Likelihood Possible Evidence D

Contraceptive Drugs

Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D

Diclofenac (Voltaren, Others)

Theoretically, chrysin might increase the effects and adverse effects of diclofenac.
In vitro research suggests that chrysin and its sulfate conjugate inhibit diclofenac metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of diclofenac by inhibiting cytochrome P450 2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D

Estrogens

Theoretically, chrysin might decrease the effects of estrogen therapy.
In vitro research suggests that chrysin might have antiestrogenic activity.

Likelihood Possible Evidence D

Mephenytoin (Mesantoin)

Theoretically, chrysin might increase the effects and adverse effects of mephenytoin.
In vitro research suggests that chrysin and its sulfate and glucuronide conjugates inhibit S-mephenytoin metabolism. It is speculated that chrysin and its conjugates reduce the metabolism of S-mephenytoin by inhibiting cytochrome P450 2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
In vitro research suggests that chrysin inhibits CYP1A2 isozymes. However, chrysin does not appear to inhibit CYP1A2-dependent caffeine metabolism in animals. Due to chrysin's low bioavailability and rapid metabolism to glucuronide and sulfate conjugates, this interaction is unlikely.

Likelihood Unlikely Evidence D

Glucuronidated Drugs

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).

Likelihood Unlikely Evidence D

Testosterone

Theoretically, chrysin might increase the effects and adverse effects of testosterone.
In vitro research suggests that chrysin and its sulfate conjugate inhibit testosterone metabolism. It is speculated that chrysin and its sulfate conjugate reduce the metabolism of testosterone by inhibiting cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D

Monograph

Chrysin: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Part used: Flavonoid extracted from plants such as passionflower and from honey and propolis
Common forms: Capsules, tablets, powders, topical gels

People commonly use it for

Bodybuilding and testosterone support
Anxiety and stress
Anti-inflammatory
Antioxidant support
Prostate health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally seems well tolerated in short-term use, but long-term safety is not well studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Chrysin is a natural compound called a flavonoid. Flavonoids are colorful plant chemicals found in many fruits, vegetables, and herbs. Chrysin specifically is found in plants such as passionflower, as well as in honey and in propolis (a substance bees make).

Supplement makers extract or produce chrysin and sell it in capsules, tablets, powders, and skin gels. It is most heavily marketed to bodybuilders and athletes who hope it will raise testosterone or limit estrogen. It is also sold for general antioxidant and anti-inflammatory support.

How it works

In laboratory studies, chrysin can act as an aromatase inhibitor, meaning it may block the enzyme that turns testosterone into estrogen. This is the main reason it became popular with bodybuilders.

Chrysin also shows antioxidant and anti-inflammatory activity in test-tube and animal experiments, where it appears to interact with cell-signaling pathways involved in inflammation.

It is important to understand that most of this evidence comes from cells in a dish or from animals. In the human body, chrysin is poorly absorbed and quickly broken down, so effects seen in the lab may not happen at all when people take it as a supplement.

Effectiveness

Does Chrysin work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 7 uses evaluated

7 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Chrysin, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 7 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Anxiety

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for anxiety, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate Athletic performance

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for improving athletic performance, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate Cancer

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for preventing cancer, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate Gout

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for gout, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate HIV/AIDS

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for HIV/AIDS, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate Male infertility

Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral chrysin for male infertility, there is insufficient reliable information about the clinical effects of chrysin for this purpose.

Insufficient Reliable Evidence To Rate Muscle strength

Rating & evidence shown verbatim from Natural Medicines

Oral chrysin has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Chrysin appears to be reasonably well tolerated in short-term human studies, but its long-term safety has not been carefully studied. Because dietary supplements are not tightly regulated, product quality and purity can vary.

People with hormone-sensitive conditions should be especially cautious, since chrysin is marketed for its possible effects on testosterone and estrogen. Anyone with a medical condition or who takes prescription medicines should check with a pharmacist or doctor first.

Pregnancy and breastfeeding: There is not enough reliable safety information for these situations. Because chrysin may affect hormones, it is best to avoid it if you are pregnant, trying to become pregnant, or breastfeeding.

Side effects

Reported side effects are uncommon and tend to be mild, but information is limited. Some people may experience stomach upset or other digestive complaints.

Because chrysin is studied so little in humans over the long term, rare or serious side effects may not be well documented. Stop using it and contact a healthcare provider if you notice an allergic reaction, such as rash, itching, or trouble breathing, or any other concerning symptoms.

Dosing

There is no well-established or proven dose for chrysin. Amounts in commercial products vary widely, and because so little is absorbed by the body, the right dose for any benefit is unknown.

If you choose to try it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist can help you review the product and decide whether it makes sense for you.

Pregnancy & Breastfeeding

Chrysin & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Chrysin & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 23 references that drive our Chrysin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. PubMed
Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22:309-12. PubMed
Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed
Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. PubMed
Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121 PubMed
Moon, Y. J., Wang, X., and Morris, M. E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 2006;20(2):187-210. PubMed
Landolfi, R., Mower, R. L., and Steiner, M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 5-1-1984;33(9):1525-1530. PubMed
Tsyrlov, I. B., Mikhailenko, V. M., and Gelboin, H. V. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim.Biophys Acta 4-13-1994;1205(2):325-335. PubMed
Collins, B. M., McLachlan, J. A., and Arnold, S. F. The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 1997;62(4):365-372. PubMed
Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139(10):4252-4263. PubMed
Liu G, Xie W, He AD, et al. Antiplatelet activity of chrysin via inhibiting platelet aIIbß3-mediated signaling pathway. Mol Nutr Food Res 2016;60(9):1984-93.
Noh K, Oh do G, Nepal MR, et al. Pharmacokinetic interaction of chrysin with caffeine in rats. Biomol Ther (Seoul) 2016;24(4):446-52. PubMed
Mohos V, Fliszár-Nyúl E, Ungvári O, et al. Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters. Drug Metab Dispos 2020;48(10):1064-10 PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Chrysin

118 brands in our database make a supplement containing Chrysin.

20S20 Nutrition 3 products Adaptogen Research 126 products Advanced Nutrition Systems 25 products AFI America's Finest 71 products Americell-Labs.com 3 products Angry Supplements 47 products ANS 20 products Arazo Nutrition 61 products ATS Labs 19 products Bel-Air Nutrition Corp 10 products Bio-Gen Innovations 1 product Biotab Nutraceuticals 3 products Body Dynamics MaXzorb Nutrition 15 products Body Dynamics MaXzorbceuticals Nutrition 11 products Bodycor Naturals 6 products Bolster Beauty by SottoPelle 3 products BulkSupplements.com 5,595 products CATALO 172 products Chaotic-Labz 37 products Combat Nutra 9 products Cooper Complete 135 products Custom Health Centers 17 products Cybergenics 12 products Designs for Health 295 products

Product directory

Supplement products with Chrysin

272 products in our database contain Chrysin. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Chrysin: Common Questions

What is Chrysin used for, and does it work?

People use Chrysin for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.

Does Chrysin interact with prescription medications?

Yes. We list 358 medications with a known interaction with Chrysin. Use the checker above to see how Chrysin interacts with a specific drug.

How are Chrysin interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Chrysin with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Chrysin interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Chrysin used for?

It is most often used by bodybuilders who hope it will raise testosterone or reduce estrogen, and it is also marketed for anxiety, inflammation, and antioxidant support. However, human evidence supporting these uses is weak.

Does Chrysin actually boost testosterone?

Human studies have generally not shown that Chrysin raises testosterone or improves muscle growth, mostly because the body absorbs very little of it when taken by mouth.

Is Chrysin safe to take?

It seems fairly well tolerated short-term, but its long-term safety is not well studied. Talk with your pharmacist or doctor before using it, especially if you have a medical condition or take other medicines.

Can I take Chrysin while pregnant or breastfeeding?

No. There is not enough safety information, and because it may affect hormones, it is best to avoid Chrysin during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Chrysin

A rotating sample of real supplements in our database that list Chrysin — open any to see its full ingredients and every drug interaction we check.

See all 272 products with Chrysin →

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Chrysin Drug Interactions, Uses, Effectiveness, Safety & More

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Drugs that interact with Chrysin

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What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Chrysin affects

Chrysin: Uses, Safety & Side Effects

Overview

How it works

Does Chrysin work?

Safety & precautions

Side effects

Dosing

Chrysin & Pregnancy

Chrysin & Breastfeeding

References & further reading

Brands that make products with Chrysin

Supplement products with Chrysin

Chrysin: Common Questions

Related supplements & herbs

Products that contain Chrysin

Have a question about Chrysin?