Medication interaction hub

What Supplements Interact with Estradiol, Norgestimate?

Estradiol, Norgestimate brand name: Ortho-Prefest. Every interaction below applies to the brands too.

159 Interactions 3 Major 126 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Estradiol, Norgestimate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Estradiol, Norgestimate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ortho-Prefest pairs estradiol with norgestimate, a hormone therapy most often prescribed for menopause symptoms, and its interaction list warrants genuine care rather than a quick skim. Of the 159 supplements and herbs on file, three carry a major rating, and all involve common products. St. John's wort can speed the hormones out of the body and weaken the therapy, activated charcoal can soak up the pills before they absorb, and grapefruit does the reverse, raising estrogen levels along with estrogen side effects.

The 126 moderate entries mostly fall into two camps. Dozens of botanicals have estrogen-like activity of their own, which can pile onto or compete with the prescription. Another large cluster involves caffeine sources such as coffee, tea, and guarana, because estrogen slows caffeine breakdown, so your usual cup may hit harder. Space any fiber or charcoal product well apart from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 126 Minor 30 No known interaction 1,293

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Estradiol, Norgestimate: Top Interactions at a Glance

The Estradiol, Norgestimate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 159 interacting ingredients — plus 1,293 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Estradiol, Norgestimate Combinations Today

The Estradiol, Norgestimate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Agar + Estradiol, Norgestimatei

Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Read the full interaction Moderate Likelihood Possible Catechu + Estradiol, Norgestimatei

Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Hemp + Estradiol, Norgestimatei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Possible Brussels Sprout + Estradiol, Norgestimatei

Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Read the full interaction Major Likelihood Probable Activated Charcoal + Estradiol, Norgestimatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Grapefruit + Estradiol, Norgestimatei

Grapefruit juice can increase blood levels of estrogens, potentially increasing the effects and adverse effects of estrogens.

Read the full interaction
The complete list

Every Supplement Checked Against Estradiol, Norgestimate

All 1,452 ingredients in our database, ranked by severity — 159 with a Estradiol, Norgestimate interaction on file and 1,293 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Estradiol, Norgestimate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Agar with Estradiol, Norgestimate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Estradiol, Norgestimate answer

Can you take Catechu with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.

Full Catechu + Estradiol, Norgestimate answer

Can you take Hemp with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Estradiol, Norgestimate answer

Can you take Brussels Sprout with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Full Brussels Sprout + Estradiol, Norgestimate answer

Can you take Kava with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Estradiol, Norgestimate answer

Can you take Kratom with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kratom might increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Kratom + Estradiol, Norgestimate answer

Can you take Kudzu with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kudzu might alter the effects of estrogen therapy.

Full Kudzu + Estradiol, Norgestimate answer

Can you take Lentinan with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory evidence suggests that lentinan might increase the activity of cytochrome P450 1A2 (CYP1A2).

Full Lentinan + Estradiol, Norgestimate answer

Can you take Licorice with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease the effects of estrogen therapy.

Full Licorice + Estradiol, Norgestimate answer

Can you take Mace with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzym...

Full Mace + Estradiol, Norgestimate answer

Can you take Methoxylated Flavones with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.

Full Methoxylated Flavones + Estradiol, Norgestimate answer

Can you take Moringa with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Estradiol, Norgestimate answer

Can you take Neem with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.

Full Neem + Estradiol, Norgestimate answer

Can you take Nutmeg with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Full Nutmeg + Estradiol, Norgestimate answer

Can you take Oregon Grape with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Estradiol, Norgestimate answer

Can you take Panax Ginseng with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Panax ginseng might interfere with hormone replacement therapy.

Full Panax Ginseng + Estradiol, Norgestimate answer

Can you take Panax Notoginseng with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Full Panax Notoginseng + Estradiol, Norgestimate answer

Can you take Parsley with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Estradiol, Norgestimate answer

Can you take Peony with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Estradiol, Norgestimate answer

Can you take Pleurisy Root with Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Full Pleurisy Root + Estradiol, Norgestimate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Estradiol, Norgestimate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Estradiol, Norgestimate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Estradiol, Norgestimate sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Estradiol, Norgestimate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Estradiol, Norgestimate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Estradiol, Norgestimate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Estradiol, Norgestimate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Estradiol, Norgestimate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Estradiol, Norgestimate through this category.

Related: does Estradiol, Norgestimate deplete any nutrients?

Estradiol, Norgestimate has 5 reported nutrient associations in the research literature — see the Estradiol, Norgestimate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Estradiol, Norgestimate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Estradiol, Norgestimate.

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Pharmacist Counseling Corner

Estradiol, Norgestimate & Supplements: Common Questions

What supplements interact with Estradiol, Norgestimate?
Our database currently documents 159 ingredients with a known Estradiol, Norgestimate interaction (3 major, 126 moderate, 30 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 159. The highest-ranked right now: Activated Charcoal, Grapefruit, St. John's Wort.
Which Estradiol, Norgestimate supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Estradiol, Norgestimate?
Plenty of supplements coexist fine with Estradiol, Norgestimate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Ortho-Prefest have the same supplement interactions as Estradiol, Norgestimate?
Yes — Ortho-Prefest all contain Estradiol, Norgestimate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Estradiol, Norgestimate deplete any vitamins or nutrients?
It might — Estradiol, Norgestimate has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Estradiol, Norgestimate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Estradiol, Norgestimate and my other medications?
This page covers Estradiol, Norgestimate against supplements and herbal ingredients. Checking Estradiol, Norgestimate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.