Qing Hao Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Qing Hao against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Qing Hao is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artemisia annua Herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Qing Hao by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Qing Hao by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Qing Hao by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Qing Hao is a single-ingredient liquid product: Sweet Annie (Artemisia annua) herb extract. The extract is also made with alcohol, water, and glycerin, which help keep it stable and make it easy to take.
Does it work?
Moderate evidence
The evidence for Sweet Annie is limited. It's possibly effective for allergic rhinitis (hay fever), though the data isn't strong.
For nonalcoholic fatty liver disease, malaria, and osteoarthritis, there isn't enough reliable evidence yet to say whether it works. If you're considering it for hay fever, talk with your pharmacist about whether the evidence is convincing enough for your situation.
How safe is it?
Well-documented data
Sweet Annie is generally well tolerated when taken by mouth, but nausea and vomiting do happen. There's also a rare but serious risk of liver damage — one documented case involved hepatitis after high-dose use, though symptoms resolved after stopping.
The supplement should not replace proven treatments and quality varies widely between products. Safety data advises against using Sweet Annie during pregnancy because of possible harm to a developing baby, and there isn't enough information to use it safely while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, check any drug metabolized by CYP3A4 or CYP2B6 (a huge class affecting hundreds of medications), and any medication that stresses your liver — these are your main concerns, both rated Moderate severity. The medication checker on this page will flag your specific prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Qing Hao may help with hay fever, but the evidence is modest. If you take any prescription medications — especially those affecting your heart, liver, or blood pressure — check them against your medications before starting.
Pregnant or breastfeeding? Skip this product.
Talk to your pharmacist about whether it's right for you and whether it might replace something proven.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Qing Hao, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7439500761730 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 327027 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Qing Hao by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Artemisia annua Herb Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Artemisia annua
Organic alcohol
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
General Statements
Organic raw material.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Qing Hao by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Qing Hao by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Artemisia annua Herb Extract, Dry
Interacts with889 drugs
Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...
Artemisia annua Herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Qing Hao by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Qing Hao by Herbal Terra contains Sweet Annie extract, which interacts with a notable number of medications.
The most serious concern is with drugs that stress your liver (hepatotoxic drugs) — there's a real possibility that taking this supplement alongside them could add to liver damage risk. The extract may also alter how your body processes certain medications.
Read the full breakdown — every affected drug type, severity by severity
Sweet Annie can change the blood levels and effects of drugs metabolized by CYP3A4 and CYP2B6, two major liver enzymes. The research here is a bit mixed: one component (artemisinin) seems to speed up these enzymes, but the whole extract appears to slow them down in lab studies.
That unpredictability means your medications could end up less effective, more effective, or just not work as expected. Altogether, these interactions span 870 individual medications.
Before you start this product, use the medication checker on this page to look up your exact prescriptions — especially if you take anything for your heart, blood pressure, cholesterol, or any condition treated with multiple drugs metabolized through those pathways.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Qing Hao?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Qing Hao interact with 889 drugs. Click any drug to see the details.
1 of the 1 ingredient in Qing Hao interact with drugs. Each result below shows which ingredient is responsible. Artemisia annua Herb Extract, Dry
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Abacavir, Lamivudine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acebutolol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Qing Hao — through 1 ingredient. Tap an ingredient for the detail:
Artemisia Annua Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Artemisia Annua Herb Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Qing Hao with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Artemisia annua Herb Extract, Dry
Cytochrome P450 2B6 (Cyp2B6) Substrates
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.
Hepatotoxic Drugs
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.
Brand information
Manufacturer and brand details for Qing Hao, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Qing Hao by Herbal Terra: Common Questions
Does Qing Hao by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant?
Is it safe to breastfeed while taking Qing Hao?
What's Sweet Annie actually used for in this product?
What side effects should I watch for?
How long can I safely take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Qing Hao is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Qing Hao’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Qing Hao's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sweet Annie 11 references
- Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
- Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
- Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
- Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
- Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
- Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
- Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
- Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
- Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
- Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
- Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC