Drug & supplement interaction

Hemp + Fenoprofen Calcium

Fenoprofen Calcium brand name: Nalfon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hemp and Fenoprofen Calcium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Fenoprofen Calcium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hemp and Fenoprofen Calcium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fenoprofen Calcium and Hemp in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hemp safety at a glance

Hemp overall Use caution Hemp seed foods are generally well tolerated, but concentrated extracts and supplements are less studied.
Pregnancy Use caution Hemp seed foods are likely fine in normal amounts, but concentrated extracts should be avoided due to limited safety data.
Breastfeeding Use caution Food amounts of hemp seed are likely okay, but supplements and extracts are not well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fenoprofen Calcium and Hemp? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fenoprofen Calcium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fenoprofen Calcium is filed under 5 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates. Hemp has documented interactions with 6 drug classes — the most serious being estrogens (moderate), ace inhibitors (aceis) (minor) and anticoagulant/antiplatelet drugs (minor) — and none of Fenoprofen Calcium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hemp Does Interact With Other Medications

Hemp has 41 moderate, 897 minor known drug interactions in our database — Fenoprofen Calcium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 Minor 897 No known interaction 1,892 (incl. Fenoprofen Calcium)
Taking anything else?

Check Another of Your Medications Against Hemp

Covers the 2,830 medications we’ve checked against Hemp. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hemp and Fenoprofen Calcium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Hemp

    “Orally, there are case reports of allergy to hemp seed, although this is uncommon. A 44-year-old male developed hives during a meal of hemp seed-crusted seafoods. Later, he developed facial swelling, shortness of breath, and problems speaking. Evaluation revealed allergy to a specific protein in hemp seed. He did not react to smoked cannabis.”

    Hemp · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 101140. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
    2. 101154. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
    3. 110288. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
    4. 101155. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Hemp

    “Orally, there is a case report of elevated liver enzymes and hepatitis in a two-year-old boy given hemp extract 2.5 mL, providing 125 mg phytocannabinoid, five to eight times daily for infantile spasms and refractory seizures. The total dose of phytocannabinoids was approximately 60-100 mg/kg daily.”

    Hemp · Natural Medicines adverse-effect record, reported in epilepsy.

    1 source cited
    1. 110287. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

  • Swelling / A skin rash Additional detail

    Hemp

    Recorded for Hemp in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Fenoprofen Calcium

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed ›

Reported for Hemp but not commonly for Fenoprofen Calcium: an irregular heartbeat, wheezing, a severe allergic reaction and seizures.

Effects for Fenoprofen Calcium come from the ADVERSE REACTIONS section of its FDA label; effects for Hemp come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Fenoprofen Calcium Products Have a Food Rule — Hemp Should Not Break It

At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Hemp on an empty stomach out of habit, keep them separate — and take Fenoprofen Calcium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Fenoprofen Calcium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Fenoprofen Calcium may be administered with meals or with milk.

From the Dosage and Administration section of the FDA label we read for Fenoprofen Calcium — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Fenoprofen Calcium Is Prescribed For, and What Hemp Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Fenoprofen Calcium is a prescription medicine with approved uses on its FDA label. Hemp is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Fenoprofen Calcium is prescribed for: Fenoprofen is used to relieve mild to moderate pain in adults. It is also used to reduce the pain, swelling, and stiffness caused by rheumatoid arthritis and osteoarthritis. These uses are supported by products including Fenoprofen Calcium, Fenopron, and Nalfon capsules. Nalfon is also available as a tablet.

Hemp has been studied for:

  • Osteoarthritis studied, not established Hemp has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Hemp for osteoarthritis

    It is unclear if oral hemp seed is beneficial in patients with osteoarthritis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Fenoprofen Calcium on your own; if you are taking Hemp for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Fenoprofen Calcium

This page covers Hemp only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenoprofen Calcium page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 16 moderate · 11 minor.

From our pharmacist’s overview on the Fenoprofen Calcium page

“The kidneys and the stomach lining take the brunt of any NSAID, and fenoprofen calcium (Nalfon), prescribed for arthritis and other pain, is no exception. This list of 32 interacting supplements deserves real caution; five carry a major rating, and understanding those five comes first.”

Reviewed by 2 · Jul 18, 2026

Open the Fenoprofen Calcium interaction page

One more smart check

Taking Hemp as Part of a Dietary Supplement Product? Check It for Interactions

We hold 720 real supplement products containing Hemp, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemp. Even though Hemp itself has no known interaction with Fenoprofen Calcium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hemp and Fenoprofen Calcium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hemp
Top 25%

#182 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fenoprofen Calcium
Top half

#1,041 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hemp reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hemp and Fenoprofen Calcium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hemp

What is Hemp?

Hemp
  • Plant-based protein source
  • Heart health support
  • Skin and hair health
  • Reducing inflammation
  • General nutrition (omega fatty acids)

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While the nutrition is real, strong human evidence that hemp supplements treat specific medical conditions is limited. Talk with your pharmacist or doctor before using hemp products for a health concern, especially if you are pregnant or breastfeeding.

Cannabis sativa · Cannabaceae · Seeds (hemp hearts), seed oil, protein powder, and sometimes leaves and extracts · Hemp seeds (hearts), hemp seed oil, hemp protein powder, capsules, and food products

An interaction check asks whether these two react with each other — it does not ask whether Hemp is a good idea for someone in your situation. Here is what our Hemp record says about it on its own.

Hemp: dosing

There is no official standard dose for hemp as a supplement. As a food, people often add a few tablespoons of hemp seeds, oil, or protein powder to meals and snacks.Because products vary widely in strength and form, the best approach is to follow the directions on the product label. They can help you decide whether it is a good fit and what amount may be reasonable for you.

From our Hemp monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hemp monograph & all interactions
Medication

About Fenoprofen

What Is Fenoprofen Used For?

Brand name: Nalfon

Fenoprofen is used to relieve mild to moderate pain in adults. It is also used to reduce the pain, swelling, and stiffness caused by rheumatoid arthritis and osteoarthritis.

These uses are supported by products including Fenoprofen Calcium, Fenopron, and Nalfon capsules. Nalfon is also available as a tablet.

See full Fenoprofen drug information
Keep checking

Other Drugs & Hemp

Browse every other medication we’ve checked against Hemp — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
897Minor
1,891No known interaction
41 Moderate 897 Minor 1,891 No interaction
Moderate

41 interactions

Minor

897 interactions

Showing 60 of 897 minor interactions — see all 897 on the Hemp page.

No interaction 1,891 drugs checked — show the list

We also checked Hemp against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,891 medications checked with no known interaction — see the full Hemp list.

See the full Hemp interactions page
See every supplement checked against Fenoprofen Calcium, ranked by severity
Evidence & sources

Hemp References

The 12 references that drive our Hemp monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hemp and Fenoprofen Calcium Together: Common Questions

Is it safe to take Hemp with Fenoprofen Calcium?
We do not list a known interaction between Hemp and Fenoprofen Calcium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hemp and Fenoprofen Calcium have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Hemp and Fenoprofen Calcium at the same time of day?
At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Hemp on an empty stomach out of habit, keep them separate and take Fenoprofen Calcium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Fenoprofen Calcium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Hemp and Fenoprofen Calcium used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Hemp in each. That is a conversation for your prescriber, especially if Fenoprofen Calcium is being adjusted to a target.
How was the Hemp and Fenoprofen Calcium combination checked?
Interactions in our licensed database are recorded against drug classes. Fenoprofen Calcium is filed under 5 classifications, and Hemp has documented interactions with 6 drug classes — none of Fenoprofen Calcium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hemp interact with any other medications?
Yes. Hemp has 938 documented drug interactions in our database — Fenoprofen Calcium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fenoprofen Calcium interact with any supplements?
Yes. Fenoprofen Calcium has documented interactions with 32 supplements in our database — Hemp is not one of them. The Fenoprofen Calcium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hemp monograph Uses, safety profile, and every drug interaction in one place Fenoprofen drug information The full plain-English guide to this medication Fenoprofen Calcium supplement interactions Every supplement checked against Fenoprofen Calcium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fenoprofen Calcium and Hemp?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.