Medication interaction hub

What Supplements Interact with Hyoscyamine, Phenobarbital?

Hyoscyamine, Phenobarbital brand names: Levsin Pb, Levsinex Pb Timecaps. Every interaction below applies to the brands too.

164 Interactions 10 Major 134 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hyoscyamine, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hyoscyamine, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The person taking Levsin PB (hyoscyamine with phenobarbital) for gut spasms is often the same person browsing calming herbs and sleep aids, and with this medicine that habit calls for real vigilance. Ten of the 164 supplements on record rate major, and the largest group, 78 ingredients, shares one danger. Anything sedating, from kava to alcohol, stacks with phenobarbital's sedation and at worst can slow breathing. St. John's wort earned its major rating differently, speeding phenobarbital's breakdown so its levels drop and it stops working.

Another 30 ingredients pile onto hyoscyamine's anticholinergic side, adding dry mouth, constipation, and blurred vision, and most of the 134 moderate and 20 minor entries trace back to these same sedative or drying effects. Absorption deserves its own attention. Charcoal and bulk fiber supplements can block the pills from absorbing, so space those well apart from doses and let your pharmacist set the exact gap.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 134 Minor 20 No known interaction 1,288

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hyoscyamine, Phenobarbital: Top Interactions at a Glance

The Hyoscyamine, Phenobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 164 interacting ingredients — plus 1,288 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hyoscyamine, Phenobarbital Combinations Today

The Hyoscyamine, Phenobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Spearmint + Hyoscyamine, Phenobarbitali

Theoretically, spearmint might alter the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Thyme + Hyoscyamine, Phenobarbitali

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Read the full interaction Moderate Likelihood Possible Calamus + Hyoscyamine, Phenobarbitali

Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Read the full interaction Moderate Likelihood Possible Corydalis Yanhusuo + Hyoscyamine, Phenobarbitali

Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Read the full interaction Major Likelihood Likely Beer + Hyoscyamine, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely St. John's Wort + Hyoscyamine, Phenobarbitali

St.

Read the full interaction
The complete list

Every Supplement Checked Against Hyoscyamine, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 164 with a Hyoscyamine, Phenobarbital interaction on file and 1,288 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hyoscyamine, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Spearmint with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Hyoscyamine, Phenobarbital answer

Can you take Thyme with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Full Thyme + Hyoscyamine, Phenobarbital answer

Can you take Calamus with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Hyoscyamine, Phenobarbital answer

Can you take Corydalis Yanhusuo with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Hyoscyamine, Phenobarbital answer

Can you take Evodia with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.

Full Evodia + Hyoscyamine, Phenobarbital answer

Can you take Fo-ti with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.

Full Fo-ti + Hyoscyamine, Phenobarbital answer

Can you take Galphimia Glauca with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Hyoscyamine, Phenobarbital answer

Can you take Gamma Butyrolactone (gbl) with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Hyoscyamine, Phenobarbital answer

Can you take German Chamomile with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Hyoscyamine, Phenobarbital answer

Can you take Golden Ragwort with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Hyoscyamine, Phenobarbital answer

Can you take Goldenseal with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the sedative effects of CNS depressants.

Full Goldenseal + Hyoscyamine, Phenobarbital answer

Can you take Gotu Kola with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Hyoscyamine, Phenobarbital answer

Can you take Gravel Root with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Hyoscyamine, Phenobarbital answer

Can you take Green Tea with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Green Tea + Hyoscyamine, Phenobarbital answer

Can you take Griffonia Simplicifolia with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Hyoscyamine, Phenobarbital answer

Can you take Groundsel with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Hyoscyamine, Phenobarbital answer

Can you take Guar Gum with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Hyoscyamine, Phenobarbital answer

Can you take Guarana with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Guarana + Hyoscyamine, Phenobarbital answer

Can you take Guarumo with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Hyoscyamine, Phenobarbital answer

Can you take Gum Arabic with Hyoscyamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Hyoscyamine, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hyoscyamine, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hyoscyamine, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hyoscyamine, Phenobarbital sits in 10 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Hyoscyamine, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Hyoscyamine, Phenobarbital through this category.

Related: does Hyoscyamine, Phenobarbital deplete any nutrients?

Hyoscyamine, Phenobarbital has 20 reported nutrient associations in the research literature — see the Hyoscyamine, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hyoscyamine, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hyoscyamine, Phenobarbital.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Hyoscyamine, Phenobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Hyoscyamine, Phenobarbital.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Hyoscyamine, Phenobarbital & Supplements: Common Questions

What supplements interact with Hyoscyamine, Phenobarbital?
In our interaction database, 164 supplement and herbal ingredients have an interaction with Hyoscyamine, Phenobarbital on file — 10 rated major, 134 moderate, and 20 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Hyoscyamine, Phenobarbital supplement interactions are the most serious?
Focus on the major group: Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hyoscyamine, Phenobarbital?
That depends entirely on which supplement. The honest answer for Hyoscyamine, Phenobarbital is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Levsin Pb have the same supplement interactions as Hyoscyamine, Phenobarbital?
Yes — Levsin Pb, Levsinex Pb Timecaps all contain Hyoscyamine, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hyoscyamine, Phenobarbital deplete any vitamins or nutrients?
It might — Hyoscyamine, Phenobarbital has 20 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hyoscyamine, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hyoscyamine, Phenobarbital and my other medications?
This page covers Hyoscyamine, Phenobarbital against supplements and herbal ingredients. Checking Hyoscyamine, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.