Medication interaction hub

What Supplements Interact with Nitroprusside?

Nitroprusside brand name: Nitropress. Every interaction below applies to the brands too.

121 Interactions 3 Major 106 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nitroprusside? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nitroprusside against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nitroprusside (Nitropress) is an IV drip used in the hospital, often in intensive care, to bring dangerously high blood pressure down within minutes, and its interaction list deserves genuine respect. Nearly every entry either adds to the drug's blood-pressure-lowering effect and risks a steep drop, or pushes pressure back up and works against it. The three major-rated entries split the same way: American hellebore can lower blood pressure sharply even in small doses, while tyramine and American mistletoe can drive it up.

Because the drip is adjusted minute by minute against a live blood pressure reading, anything a patient took beforehand that nudges pressure in either direction complicates that job, so the care team should know about every supplement, even everyday ones like fish oil. The rest of the list, 106 moderate entries and 12 minor ones, mostly repeats that same push-and-pull at lower stakes.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 106 Minor 12 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nitroprusside: Top Interactions at a Glance

The most significant Nitroprusside supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nitroprusside + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Nitroprussidei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Nitroprussidei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable American Mistletoe + Nitroprussidei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction
The complete list

Every Supplement Checked Against Nitroprusside

All 1,452 ingredients in our database, ranked by severity — 121 with a Nitroprusside interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nitroprusside?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Tribulus with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Nitroprusside answer

Can you take Fish Oil with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Nitroprusside answer

Can you take Japanese Persimmon with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Japanese persimmon is thought to have hypotensive effects.

Full Japanese Persimmon + Nitroprusside answer

Can you take Java Tea with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some preliminary clinical evidence suggests that Java tea has antihypertensive effects.

Full Java Tea + Nitroprusside answer

Can you take L-arginine with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Full L-arginine + Nitroprusside answer

Can you take Olive Oil with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking olive oil with antihypertensive drugs might have additive effects on blood pressure.

Full Olive Oil + Nitroprusside answer

Can you take Periwinkle with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constitu...

Full Periwinkle + Nitroprusside answer

Can you take Sesame with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.

Full Sesame + Nitroprusside answer

Can you take Sodium with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Nitroprusside answer

Can you take Taurine with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Taurine + Nitroprusside answer

Can you take Wild Carrot with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive doses of wild carrot seed oil might interfere with antihypertensive therapy due to cardiotonic effects.

Full Wild Carrot + Nitroprusside answer

Can you take Wine with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Wine + Nitroprusside answer

Can you take Yohimbe with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might reduce the effects of antihypertensive drugs.

Full Yohimbe + Nitroprusside answer

Can you take Adrafinil with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the effects of antihypertensive drugs.

Full Adrafinil + Nitroprusside answer

Can you take Agmatine with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Nitroprusside answer

Can you take Algal Oil with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.

Full Algal Oil + Nitroprusside answer

Can you take Andrographis with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.

Full Andrographis + Nitroprusside answer

Can you take Artichoke with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Nitroprusside answer

Can you take Asafoetida with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Nitroprusside answer

Can you take Ash with Nitroprusside?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Nitroprusside answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nitroprusside is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nitroprusside, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nitroprusside sits in 2 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Nitroprusside through this category.

Nitroprusside (Nitropress) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Nitroprusside through this category.

Related: does Nitroprusside deplete any nutrients?

Nitroprusside has 1 reported nutrient association in the research literature — see the Nitroprusside nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nitroprusside

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nitroprusside.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Nitroprusside & Supplements: Common Questions

What supplements interact with Nitroprusside?
In our interaction database, 121 supplement and herbal ingredients have an interaction with Nitroprusside on file — 3 rated major, 106 moderate, and 12 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Tyramine, American Mistletoe.
Which Nitroprusside supplement interactions are the most serious?
The 3 major-rated combinations — led by American Hellebore, Tyramine and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Nitroprusside?
That depends entirely on which supplement. The honest answer for Nitroprusside is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Nitropress have the same supplement interactions as Nitroprusside?
Yes — Nitropress all contain Nitroprusside, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nitroprusside deplete any vitamins or nutrients?
It might — Nitroprusside has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nitroprusside nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nitroprusside and my other medications?
This page covers Nitroprusside against supplements and herbal ingredients. Checking Nitroprusside against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.