Hemp - Hydroflumethiazide, Reserpine Interaction
Herbal: Hemp
Also Known As: Cannabis sativa, Cheungsam, Fiber Hemp, Hemp Cake, Hemp Extract, Hemp Heart, Hemp Leaf, Hemp Oil, Hemp Powder, Hemp Protein, Hemp Seed, Hemp Seed Oil, Hemp Sprout, Industrial Hemp, Mazain, Shadanaj, Shahdaneh
Drug: Hydroflumethiazide, Reserpine
Brand names:
Salutensin-Demi, Salutensin
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Hydroflumethiazide, Reserpine is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46.
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia.
Hemp Overview
Hemp, a versatile plant belonging to the Cannabis sativa species, is widely recognized for its industrial, medicinal, and nutritional applications. As a dietary supplement, hemp is prized for its rich profile of essential fatty acids, particularly omega-3 and omega-6, which are crucial for overall health. The seeds of the hemp plant are a nutrient-dense source of protein, containing all nine essential amino acids. Additionally, hemp is a good source of vitamins, minerals, and antioxidants. The consumption of hemp as a dietary supplement has gained popularity for its potential benefits in supporting heart health, reducing inflammation, and providing a sustainable and plant-based protein option.
Hemp - More Interactions
Hemp interacts with 914 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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