Medication interaction hub

What Supplements Interact with Lesinurad?

Lesinurad brand name: Zurampic. Every interaction below applies to the brands too.

97 Interactions 1 Major 74 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lesinurad? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lesinurad against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Activated charcoal is the one major-rated entry among the 97 supplements and herbs on file for lesinurad (Zurampic), and it undermines the drug directly. Charcoal binds medicines in the gut and can cut how much lesinurad you absorb, letting uric acid climb and gout flare. Treat this page with genuine care, beginning with charcoal and the other absorption-related items, mostly charcoals and bulky fibers like glucomannan, which need real distance from dose time.

The largest cluster, 64 ingredients, involves CYP2C9, the liver enzyme that clears lesinurad. CBD is one that may slow this enzyme and push lesinurad levels higher than intended. Beyond charcoal, the entries split into 74 moderate and 22 minor. Another 19 are herbs carrying pyrrolizidine alkaloids, compounds hard on the liver, where the worry runs toward liver harm from the pairing rather than a weaker gout drug.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 74 Minor 22 No known interaction 1,355

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lesinurad: Top Interactions at a Glance

The Lesinurad supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 97 interacting ingredients — plus 1,355 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lesinurad Combinations Today

The Lesinurad + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Devil's Claw + Lesinuradi

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Minor Likelihood Possible Ginger + Lesinuradi

Theoretically, ginger might increase the levels of CYP2C9 substrates.

Read the full interaction Moderate Likelihood Possible Grapefruit + Lesinuradi

Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Butterbur + Lesinuradi

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Read the full interaction Moderate Likelihood Possible Gum Arabic + Lesinuradi

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Read the full interaction Moderate Likelihood Possible Tansy Ragwort + Lesinuradi

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in tansy ragwort.

Read the full interaction
The complete list

Every Supplement Checked Against Lesinurad

All 1,452 ingredients in our database, ranked by severity — 97 with a Lesinurad interaction on file and 1,355 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lesinurad?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.

Full Devil's Claw + Lesinurad answer

Can you take Ginger with Lesinurad?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP2C9 substrates.

Full Ginger + Lesinurad answer

Can you take Grapefruit with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP2C9.

Full Grapefruit + Lesinurad answer

Can you take Butterbur with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Lesinurad answer

Can you take Gum Arabic with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Lesinurad answer

Can you take Ginkgo with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might increase levels of drugs metabolized by CYP2C9.

Full Ginkgo + Lesinurad answer

Can you take Goji with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.

Full Goji + Lesinurad answer

Can you take Golden Ragwort with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Lesinurad answer

Can you take Goldenseal with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase serum levels of drugs metabolized by CYP2C9.

Full Goldenseal + Lesinurad answer

Can you take Gravel Root with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Lesinurad answer

Can you take Groundsel with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Lesinurad answer

Can you take Guar Gum with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Lesinurad answer

Can you take Gymnema with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.

Full Gymnema + Lesinurad answer

Can you take Hemp Agrimony with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Full Hemp Agrimony + Lesinurad answer

Can you take Hound's Tongue with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers can increase the toxicity of the pyrrolizidine alkaloid (PA) constituents of hound's tongue.

Full Hound's Tongue + Lesinurad answer

Can you take Inosine with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Inosine might reduce the effects of antigout medications.

Full Inosine + Lesinurad answer

Can you take Ipriflavone with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).

Full Ipriflavone + Lesinurad answer

Can you take Jambolan with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some in vitro evidence that jambolan can inhibit CYP2C9.

Full Jambolan + Lesinurad answer

Can you take Kava with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kava might increase levels of CYP2C9 substrates.

Full Kava + Lesinurad answer

Can you take Licorice with Lesinurad?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.

Full Licorice + Lesinurad answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lesinurad is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lesinurad, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lesinurad sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Lesinurad through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Lesinurad through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lesinurad through this category.

Antigout Drugs 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lesinurad through this category.

About Lesinurad

Lesinurad is a prescription medication also sold under the brand name Zurampic. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Lesinurad  ·  Brand name: Zurampic.

See the full Lesinurad drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lesinurad

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lesinurad.

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Pharmacist Counseling Corner

Lesinurad & Supplements: Common Questions

What supplements interact with Lesinurad?
In our interaction database, 97 supplement and herbal ingredients have an interaction with Lesinurad on file — 1 rated major, 74 moderate, and 22 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Cannabidiol (cbd), Coffee Charcoal.
Which Lesinurad supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lesinurad?
That depends entirely on which supplement. The honest answer for Lesinurad is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zurampic have the same supplement interactions as Lesinurad?
Yes — Zurampic all contain Lesinurad, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lesinurad and my other medications?
This page covers Lesinurad against supplements and herbal ingredients. Checking Lesinurad against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lesinurad drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.