Medication interaction hub

What Supplements Interact with Vonoprazan, Amoxicillin?

Vonoprazan, Amoxicillin brand name: Voquezna Dual. Every interaction below applies to the brands too.

203 Interactions 7 Major 157 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Vonoprazan, Amoxicillin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Vonoprazan, Amoxicillin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Voquezna Dual Pak pairs vonoprazan, an acid blocker, with amoxicillin to wipe out H. pylori, the stomach bug behind many ulcers, and this list deserves real care because a half-treated infection can come roaring back. Vonoprazan is broken down by the liver enzyme CYP3A4, which explains why 121 of the 203 ingredients on file touch it in some way. Grapefruit can push vonoprazan levels up, while St. John's wort can drain them, and both rate major here.

The other majors involve alcohol adding to liver strain, two herbs hard on the kidneys, and activated charcoal, which soaks up medicine in the gut before it can absorb. Probiotics fill out much of the moderate column; amoxicillin kills the live organisms they contain, so take them well apart from your doses. Understanding the seven majors matters most, since the 157 moderates and 39 minors mostly repeat these patterns in gentler form.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 157 Minor 39 No known interaction 1,249

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Vonoprazan, Amoxicillin: Top Interactions at a Glance

The Vonoprazan, Amoxicillin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 203 interacting ingredients — plus 1,249 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Vonoprazan, Amoxicillin Combinations Today

The Vonoprazan, Amoxicillin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Licorice + Vonoprazan, Amoxicillini

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Vonoprazan, Amoxicillini

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Moderate Likelihood Probable Fermented Milk + Vonoprazan, Amoxicillini

Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Read the full interaction Moderate Likelihood Possible Berberine + Vonoprazan, Amoxicillini

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Goji + Vonoprazan, Amoxicillini

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Horny Goat Weed + Vonoprazan, Amoxicillini

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Vonoprazan, Amoxicillin

All 1,452 ingredients in our database, ranked by severity — 203 with a Vonoprazan, Amoxicillin interaction on file and 1,249 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Vonoprazan, Amoxicillin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Licorice with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Vonoprazan, Amoxicillin answer

Can you take Slippery Elm with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Vonoprazan, Amoxicillin answer

Can you take Fermented Milk with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Vonoprazan, Amoxicillin answer

Can you take Berberine with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Vonoprazan, Amoxicillin answer

Can you take Goji with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Vonoprazan, Amoxicillin answer

Can you take Ginger with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Vonoprazan, Amoxicillin answer

Can you take Ginkgo with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Vonoprazan, Amoxicillin answer

Can you take Goldenseal with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Vonoprazan, Amoxicillin answer

Can you take Goldthread with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Vonoprazan, Amoxicillin answer

Can you take Gotu Kola with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Vonoprazan, Amoxicillin answer

Can you take Grape with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Vonoprazan, Amoxicillin answer

Can you take Greater Celandine with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Vonoprazan, Amoxicillin answer

Can you take Guar Gum with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Vonoprazan, Amoxicillin answer

Can you take Gum Arabic with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Vonoprazan, Amoxicillin answer

Can you take Hemp Agrimony with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Vonoprazan, Amoxicillin answer

Can you take Higenamine with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Vonoprazan, Amoxicillin answer

Can you take Horny Goat Weed with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Vonoprazan, Amoxicillin answer

Can you take Hu Zhang with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Full Hu Zhang + Vonoprazan, Amoxicillin answer

Can you take Indian Long Pepper with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Vonoprazan, Amoxicillin answer

Can you take Kava with Vonoprazan, Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Vonoprazan, Amoxicillin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Vonoprazan, Amoxicillin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Vonoprazan, Amoxicillin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Vonoprazan, Amoxicillin sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Vonoprazan, Amoxicillin through this category.

Related: does Vonoprazan, Amoxicillin deplete any nutrients?

Vonoprazan, Amoxicillin has 7 reported nutrient associations in the research literature — see the Vonoprazan, Amoxicillin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Vonoprazan, Amoxicillin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Vonoprazan, Amoxicillin.

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Pharmacist Counseling Corner

Vonoprazan, Amoxicillin & Supplements: Common Questions

What supplements interact with Vonoprazan, Amoxicillin?
More than you might expect — 203 in total, though they are far from equal: 7 are rated major, 157 moderate, and 39 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Vonoprazan, Amoxicillin supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Vonoprazan, Amoxicillin?
Usually yes — most people on Vonoprazan, Amoxicillin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Voquezna Dual have the same supplement interactions as Vonoprazan, Amoxicillin?
Yes — Voquezna Dual all contain Vonoprazan, Amoxicillin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Vonoprazan, Amoxicillin deplete any vitamins or nutrients?
It might — Vonoprazan, Amoxicillin has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Vonoprazan, Amoxicillin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Vonoprazan, Amoxicillin and my other medications?
This page covers Vonoprazan, Amoxicillin against supplements and herbal ingredients. Checking Vonoprazan, Amoxicillin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.