Chlorpheniramine

23 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Glucagon Injection / Solution Hydroxychloroquine Linezolid Injection Palonosetron Injection Morphine Injection

23 Major

All (23) Major (23)

Major

Chlorpheniramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Chlorpheniramine Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Chlorpheniramine Sertraline Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Chlorpheniramine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Chlorpheniramine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Chlorpheniramine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Chlorpheniramine Dolasetron Anzemet Increased risk of serotonin syndrome Details Chlorpheniramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Chlorpheniramine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Chlorpheniramine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Chlorpheniramine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Chlorpheniramine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Chlorpheniramine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Chlorpheniramine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Chlorpheniramine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Chlorpheniramine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Chlorpheniramine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Chlorpheniramine Hydroxychloroquine Plaquenil An increased risk of seizures Details Chlorpheniramine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Chlorpheniramine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Chlorpheniramine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Chlorpheniramine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Chlorpheniramine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.