Glyburide

79 interactions 4 explained in plain English

Also sold as: DiaBeta® Glynase Glynase® Micronase®

About Glyburide

Glyburide is a sulfonylurea medication that lowers blood sugar in people with type 2 diabetes. Read the full Glyburide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acarbose Moxifloxacin Ophthalmic Belumosudil Orlistat Fluorouracil Injection Disopyramide

42 Major 37 Moderate

All (79) Major (42) Moderate (37)

Moderate

Glyburide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Glyburide Aspirin Acuprin® Increased risk of hypoglycemia Details Glyburide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Glyburide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Benazepril Lotensin An increased risk of hypoglycemia Details Glyburide Alogliptin Nesina An increased risk of hypoglycemia Details Glyburide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Captopril Capoten® An increased risk of hypoglycemia Details Glyburide Chloramphenicol Injection Chloromycetin® Injection Excessive hypoglycemia Details Glyburide Colesevelam Welchol Decreased glyBURIDE exposure and plasma concentrations Details Glyburide Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Glyburide Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Glyburide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Glyburide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Glyburide Enalapril Epaned An increased risk of hypoglycemia Details Glyburide Encorafenib Braftovi Increased OATP1B1 substrate exposure, increased OATP1B3 substrate exposure, increased risk of OATP1B1 substrate-related toxicities... Details Glyburide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Glyburide Fluvastatin Lescol Increased glyBURIDE exposure Details Glyburide Fosinopril Monopril® An increased risk of hypoglycemia Details Glyburide Gemfibrozil Lopid Hypoglycemia Details Glyburide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Levothyroxine Ermeza Worsening of glycemic control Details Glyburide Linagliptin Tradjenta An increased risk of hypoglycemia Details Glyburide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Glyburide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Glyburide Metformin Fortamet® An increased risk of hypoglycemia Details Glyburide Mitapivat Aqvesme Reduced CYP2C9 substrate exposure Details Glyburide Moexipril Univasc® An increased risk of hypoglycemia Details Glyburide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Glyburide Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.