Herb & supplement monograph

Limonene Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Limonene interacts with medications. The heart of this page is the interaction list — every drug Limonene is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Limonene is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Limonene Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Limonene drug interaction appears low for most people. None of the listed interactions are rated major, and every one rests on preliminary lab evidence that has not been confirmed in humans.

Interactions deserving the most attention

Honestly, no interaction in this profile is well documented in people, since all are graded as only possible. The main theoretical concern is that limonene may lower the levels of medicines the body clears through a certain liver enzyme, which includes NSAIDs such as diclofenac. In the other direction, drugs like fluconazole and amiodarone could raise limonene levels, while rifampin and carbamazepine could lower them, making limonene itself less effective. Watching for changes with these combinations is reasonable, but no problems have been reported so far.

What the rest of the list means

The long list of medications mainly reflects how many common drugs share the enzymes limonene might affect, not proof of harm. Nearly all of these pairings are theoretical, predicted from lab research on how the body processes medicines, and none of the expected effects have actually been reported in people.

Check your medications against Limonene

Based on HelloPharmacist’s Limonene interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Limonene

230 medications have a known interaction with Limonene, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Limonene using our pharmacist-reviewed interaction data.

AI summaries are generated from our Limonene interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Limonene combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Limonene affects

Every type of medication (drug category) Limonene is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Limonene interacts with

Cytochrome P450 2c19 (cyp2c19) InducersCytochrome P450 2c19 (cyp2c19) InhibitorsCytochrome P450 2c9 (cyp2c9) InducersCytochrome P450 2c9 (cyp2c9) InhibitorsCytochrome P450 2c9 (cyp2c9) Substrates

Cytochrome P450 2C19 (Cyp2C19) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). CYP2C19 inducers might decrease the effects of limonene. So far, this interaction has not been reported in humans. Inducers of CYP2C19 include carbamazepine (Tegretol), prednisone (Deltasone), and rifampin (Rifadin, Rimactane).