Medication interaction hub

What Supplements Interact with Fedratinib Hydrochloride?

Fedratinib Hydrochloride brand name: Inrebic. Every interaction below applies to the brands too.

173 Interactions 6 Major 129 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fedratinib Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fedratinib Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People taking fedratinib (Inrebic) for myelofibrosis, a bone marrow cancer, often reach for supplements to help with fatigue, sleep, or appetite, and this is a list that warrants real care before adding any of them. Six of the 173 ingredients on file are rated major, and the dominant theme, covering 121 of them, is the CYP3A4 enzyme that clears fedratinib. Grapefruit can push drug levels up toward toxicity, while St. John's wort can pull them down until treatment quietly loses ground.

Another 38 entries add strain to the liver, which fedratinib can already stress on its own, and regular alcohol lands in that group with a major rating. A smaller set interferes with absorption from the gut, so bulky or binding products should be spaced well apart from a dose. Start with the six majors, then weigh the 129 moderates and 38 minors as they apply to you.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 129 Minor 38 No known interaction 1,279

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fedratinib Hydrochloride: Top Interactions at a Glance

The most significant Fedratinib Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 173 interacting ingredients — plus 1,279 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Fedratinib Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Fedratinib Hydrochloridei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Fedratinib Hydrochloridei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Fedratinib Hydrochloridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Fedratinib Hydrochloridei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable St. John's Wort + Fedratinib Hydrochloridei

St.

Read the full interaction Major Likelihood Probable Wine + Fedratinib Hydrochloridei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Fedratinib Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 173 with a Fedratinib Hydrochloride interaction on file and 1,279 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fedratinib Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Niacin with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Fedratinib Hydrochloride answer

Can you take Noni with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Fedratinib Hydrochloride answer

Can you take Oregon Grape with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Fedratinib Hydrochloride answer

Can you take Ostarine with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Fedratinib Hydrochloride answer

Can you take Padang Cassia with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Fedratinib Hydrochloride answer

Can you take Panax Ginseng with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Fedratinib Hydrochloride answer

Can you take Peony with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Fedratinib Hydrochloride answer

Can you take Peppermint with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP2C19 substrates.

Full Peppermint + Fedratinib Hydrochloride answer

Can you take Phellodendron with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Fedratinib Hydrochloride answer

Can you take Propolis with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.

Full Propolis + Fedratinib Hydrochloride answer

Can you take Quercetin with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Fedratinib Hydrochloride answer

Can you take Rabdosia Rubescens with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Fedratinib Hydrochloride answer

Can you take Red Yeast Rice with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Fedratinib Hydrochloride answer

Can you take Resveratrol with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.

Full Resveratrol + Fedratinib Hydrochloride answer

Can you take Rhubarb with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Rhubarb + Fedratinib Hydrochloride answer

Can you take Rooibos with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2C19 substrates may increase the effects of CYP2C19 substrates.

Full Rooibos + Fedratinib Hydrochloride answer

Can you take Sage with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.

Full Sage + Fedratinib Hydrochloride answer

Can you take Saigon Cinnamon with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Fedratinib Hydrochloride answer

Can you take Schizonepeta with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Fedratinib Hydrochloride answer

Can you take Slippery Elm with Fedratinib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Fedratinib Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fedratinib Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fedratinib Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fedratinib Hydrochloride sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fedratinib Hydrochloride through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Fedratinib Hydrochloride through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Fedratinib Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fedratinib Hydrochloride through this category.

About Fedratinib Hydrochloride

Fedratinib is a targeted kinase inhibitor used to treat intermediate-2 or high-risk myelofibrosis in adults.

Generic name: Fedratinib Hydrochloride  ·  Brand name: Inrebic.

See the full Fedratinib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fedratinib Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fedratinib Hydrochloride.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Fedratinib Hydrochloride & Supplements: Common Questions

What supplements interact with Fedratinib Hydrochloride?
Our database currently documents 173 ingredients with a known Fedratinib Hydrochloride interaction (6 major, 129 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 173. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Fedratinib Hydrochloride supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Fedratinib Hydrochloride?
Plenty of supplements coexist fine with Fedratinib Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Inrebic have the same supplement interactions as Fedratinib Hydrochloride?
Yes — Inrebic all contain Fedratinib Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fedratinib Hydrochloride and my other medications?
This page covers Fedratinib Hydrochloride against supplements and herbal ingredients. Checking Fedratinib Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fedratinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.