Medication interaction hub

What Supplements Interact with Naproxen, Sumatriptan?

Naproxen, Sumatriptan brand name: Treximet. Every interaction below applies to the brands too.

332 Interactions 14 Major 273 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Naproxen, Sumatriptan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Naproxen, Sumatriptan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Treximet combines naproxen, an anti-inflammatory painkiller, with sumatriptan for migraine, and that pairing gives its interaction list real teeth. Of the 332 supplements and herbs on file, 14 carry a major rating, and those are the entries to understand first. The largest cluster, over 200 ingredients, adds to bleeding risk, which matters because naproxen already irritates the stomach and interferes with clotting on its own. Even beer and wine sit among the majors for gastrointestinal bleeding.

A smaller group works on the sumatriptan side, raising the odds of serotonin syndrome, a dangerous overload of serotonin activity. About a dozen more, grapefruit in large amounts among them, can disturb the heart's electrical rhythm. The remaining entries split 273 moderate and 45 minor. Activated charcoal is a different problem entirely, since it can soak up the medication before your body absorbs it, so keep the two well spaced.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 273 Minor 45 No known interaction 1,120

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Naproxen, Sumatriptan: Top Interactions at a Glance

The Naproxen, Sumatriptan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 332 interacting ingredients — plus 1,120 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Naproxen, Sumatriptan Combinations Today

The Naproxen, Sumatriptan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Unlikely Coffee + Naproxen, Sumatriptani

Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Magnesium + Naproxen, Sumatriptani

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Echinacea + Naproxen, Sumatriptani

Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Read the full interaction Moderate Likelihood Possible Nutmeg + Naproxen, Sumatriptani

Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Lycopene + Naproxen, Sumatriptani

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction Minor Likelihood Unlikely Pomegranate + Naproxen, Sumatriptani

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.

Read the full interaction
The complete list

Every Supplement Checked Against Naproxen, Sumatriptan

All 1,452 ingredients in our database, ranked by severity — 332 with a Naproxen, Sumatriptan interaction on file and 1,120 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Naproxen, Sumatriptan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Coffee + Naproxen, Sumatriptan answer

Can you take Magnesium with Naproxen, Sumatriptan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Naproxen, Sumatriptan answer

Can you take Echinacea with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Full Echinacea + Naproxen, Sumatriptan answer

Can you take Nutmeg with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Full Nutmeg + Naproxen, Sumatriptan answer

Can you take Lycopene with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Naproxen, Sumatriptan answer

Can you take Berberine with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Full Berberine + Naproxen, Sumatriptan answer

Can you take Bilberry with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bilberry + Naproxen, Sumatriptan answer

Can you take Bishop's Weed with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Naproxen, Sumatriptan answer

Can you take Bismuth with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of bismuth subgallate or other bismuth salts might reduce the effects of anticoagulant/antiplatelet drugs.

Full Bismuth + Naproxen, Sumatriptan answer

Can you take Bitter Orange with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Naproxen, Sumatriptan answer

Can you take Black Cohosh with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + Naproxen, Sumatriptan answer

Can you take Black Currant with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Full Black Currant + Naproxen, Sumatriptan answer

Can you take Black Hoof Mushroom with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Full Black Hoof Mushroom + Naproxen, Sumatriptan answer

Can you take Black Pepper with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.

Full Black Pepper + Naproxen, Sumatriptan answer

Can you take Black Seed with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + Naproxen, Sumatriptan answer

Can you take Black Tea with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Naproxen, Sumatriptan answer

Can you take Blood Irradiation Therapy with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Naproxen, Sumatriptan answer

Can you take Boldo with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Boldo + Naproxen, Sumatriptan answer

Can you take Borage with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Naproxen, Sumatriptan answer

Can you take Boswellia Serrata with Naproxen, Sumatriptan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Full Boswellia Serrata + Naproxen, Sumatriptan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Naproxen, Sumatriptan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Naproxen, Sumatriptan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Naproxen, Sumatriptan sits in 13 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Naproxen, Sumatriptan through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Naproxen, Sumatriptan through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Naproxen, Sumatriptan through this category.

Related: does Naproxen, Sumatriptan deplete any nutrients?

Naproxen, Sumatriptan has 1 reported nutrient association in the research literature — see the Naproxen, Sumatriptan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Naproxen, Sumatriptan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Naproxen, Sumatriptan.

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Products that contain Naproxen, Sumatriptan-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Naproxen, Sumatriptan.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Naproxen, Sumatriptan & Supplements: Common Questions

What supplements interact with Naproxen, Sumatriptan?
Our database currently documents 332 ingredients with a known Naproxen, Sumatriptan interaction (14 major, 273 moderate, 45 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 332. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Arsenic.
Which Naproxen, Sumatriptan supplement interactions are the most serious?
The 14 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Arsenic, Beer and Cesium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Naproxen, Sumatriptan?
Plenty of supplements coexist fine with Naproxen, Sumatriptan; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Treximet have the same supplement interactions as Naproxen, Sumatriptan?
Yes — Treximet all contain Naproxen, Sumatriptan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Naproxen, Sumatriptan deplete any vitamins or nutrients?
It might — Naproxen, Sumatriptan has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Naproxen, Sumatriptan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Naproxen, Sumatriptan and my other medications?
This page covers Naproxen, Sumatriptan against supplements and herbal ingredients. Checking Naproxen, Sumatriptan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.