Acalabrutinib

153 interactions 1 explained in plain English 312 cited references

Also sold as: Calquence Calquence®

About Acalabrutinib

Acalabrutinib is used to treat people with mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other chemotherapy medication. It is also used alone or with obinutuzumab (Gazyva) to treat chronic lymphocytic leukemia (CLL; a type… Read the full Acalabrutinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Measles Virus Vaccine, Live Levoketoconazole Ensitrelvir Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live

12 Contraindicated 134 Major 7 Moderate

All (153) Contraindicated (12) Major (134) Moderate (7)

Contraindicated

Acalabrutinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Acalabrutinib Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Acalabrutinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Mifepristone Korlym Increased CYP3A4 substrate with NTI exposure Details Acalabrutinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Acalabrutinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Acalabrutinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Acalabrutinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Acalabrutinib Omeprazole Gastrobim Reduced acalabrutinib exposure Details Acalabrutinib Adagrasib Krazati Increased CYP3A4 substrate exposure Details Acalabrutinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Acalabrutinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Acalabrutinib Aluminum Carbonate, Basic Reduced acalabrutinib exposure Details Acalabrutinib Aluminum Hydroxide AlternaGEL® Reduced acalabrutinib exposure Details Acalabrutinib Aluminum Phosphate Reduced acalabrutinib exposure Details Acalabrutinib Apalutamide Erleada Reduced acalabrutinib exposure Details Acalabrutinib Aprepitant Aponvie Increased acalabrutinib exposure and increased risk of toxicity Details Acalabrutinib Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Acalabrutinib Atazanavir Reyataz Increased acalabrutinib exposure and increased risk of toxicity Details Acalabrutinib Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Acalabrutinib Belzutifan Welireg Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Acalabrutinib Berotralstat Orladeyo Increased CYP3A4 substrate exposure and an increased CYP3A4 substrate-related adverse reactions Details Acalabrutinib Boceprevir Increased acalabrutinib exposure Details Acalabrutinib Calcium Carbonate Alka-Mints Reduced acalabrutinib exposure Details Acalabrutinib Carbamazepine Carbatrol Reduced acalabrutinib exposure Details Acalabrutinib Ceritinib Zykadia Increased exposure of CYP3A substrate Details Acalabrutinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Acalabrutinib Cimetidine Tagamet Reduced acalabrutinib exposure Details Acalabrutinib Ciprofloxacin Increased acalabrutinib exposure and increased risk of toxicity Details Acalabrutinib Clarithromycin Biaxin Increased acalabrutinib exposure Details Acalabrutinib Cobicistat Tybost Increased acalabrutinib exposure Details Acalabrutinib Conivaptan Vaprisol Increased acalabrutinib exposure Details Acalabrutinib Crizotinib Xalkori Increased acalabrutinib exposure and increased risk of toxicity Details Acalabrutinib Cyclosporine Atopica Increased acalabrutinib exposure and increased risk of toxicity Details Acalabrutinib Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Acalabrutinib Daridorexant Increased CYP3A4 substrate with NTI exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.