Drug & supplement interaction

Kava + Lanadelumab (Shp643)

Lanadelumab (Shp643) brand name: Takhzyro.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Kava and Lanadelumab (Shp643) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Kava and Lanadelumab (Shp643)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lanadelumab (Shp643) and Kava in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kava safety at a glance

Kava overall Use caution Kava may help anxiety but has been linked to rare, serious liver injury and is banned or restricted in some countries.
Pregnancy Avoid Kava is not considered safe during pregnancy and should be avoided.
Breastfeeding Possibly Unsafe When used orally. There is concern that the toxic pyrone constituents of kava can pass into breast milk; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lanadelumab (Shp643) and Kava? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Kava Does Interact With Other Medications

Kava has 248 major, 577 moderate, 341 minor known drug interactions in our database — Lanadelumab (Shp643) isn’t one of them. If you take anything else, check it against the full list below.

Major 248 Moderate 577 Minor 341 No known interaction 1,664 (incl. Lanadelumab (Shp643))
Taking anything else?

Check Another of Your Medications Against Kava

Covers the 2,830 medications we’ve checked against Kava. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Kava and Lanadelumab (Shp643) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Kava

    “Orally, kava can cause allergic skin reactions, including sebotropic eruptions, delayed-type hypersensitivity, or urticarial eruption. In one case of kava-associated urticarial eruption, biopsy revealed neutrophilic sebaceous glands with lymphocytic infiltrate. Chronic use of high doses of kava has also been associated with kava dermopathy, which consists of reddened eyes; dry, scaly, flaky skin;”

    Kava · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 4032. Wheatley D. Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum Psychopharmacol 2001;16:353-6. PubMed
    2. 11370. Schmidt P, Boehncke WH. Delayed-type hypersensitivity reaction to kava-kava extract. Contact Dermatitis 2000;42:363-4.
    3. 28489. Huynh JC, Asgari MM, Moore MM. Sebotropic eruption associated with use of oral kava kava supplement. Clin Exp Dermatol 2014;39(7):816-8. PubMed
    4. 57277. Grace, R. Kava-induced urticaria. J Am Acad Dermatol 2005;53(5):906. PubMed
    5. 57325. Jappe, U., Franke, I., Reinhold, D., and Gollnick, H. P. Sebotropic drug reaction resulting from kava-kava extract therapy: a new entity? J Am Acad Dermatol. 1998;38(1):104-106. PubMed
    6. 57343. Siegers CP, Honold E, Krall B, and et al. Results of the drug monitoring L 1090 with Laitan capsules. Arztl Forsch 1992;39:7-11.

    Lanadelumab (Shp643)

    Listed in the ADVERSE REACTIONS section of the FDA label for Lanadelumab (Shp643). Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Kava

    “Orally, kava may cause headache, dizziness, and drowsiness. It might also cause extrapyramidal side effects such as involuntary oral and lingual reflexes, twisting movements of the head and trunk, tremors, and other parkinsonian-like symptoms possibly due to dopamine antagonism.”

    Kava · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 4032. Wheatley D. Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum Psychopharmacol 2001;16:353-6. PubMed
    2. 6402. Mathews JD, Riley MD, Fejo L, et al. Effects of heavy usage of kava on physical health: Summary of a pilot survey in an aboriginal community. Med J Aust 1988;148:548-55.
    3. 11370. Schmidt P, Boehncke WH. Delayed-type hypersensitivity reaction to kava-kava extract. Contact Dermatitis 2000;42:363-4.
    4. 11372. Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev 2003;(1):CD003383.
    5. 11373. Cairney S, Maruff P, Clough AR, et al. Saccade and cognitive impairment associated with kava intoxication. Hum Psychopharmacol 2003;18:525-33. PubMed
    6. 18316. Sarris J, Kavanagh DJ, Byrne G, et al. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology 2009;205:399-407. PubMed

    Lanadelumab (Shp643)

    Listed in the ADVERSE REACTIONS section of the FDA label for Lanadelumab (Shp643). Read the label on DailyMed ›

  • A skin rash Additional detail

    Kava

    Recorded for Kava in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Lanadelumab (Shp643)

    Listed in the ADVERSE REACTIONS section of the FDA label for Lanadelumab (Shp643). Read the label on DailyMed ›

Reported for Kava but not commonly for Lanadelumab (Shp643): stomach upset, shortness of breath, a low platelet count and memory problems.

Effects for Lanadelumab (Shp643) come from the ADVERSE REACTIONS section of its FDA label; effects for Kava come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Kava in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally. There is concern that the toxic pyrone constituents of kava can pass into breast milk; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Kava as Part of a Dietary Supplement Product? Check It for Interactions

We hold 403 real supplement products containing Kava, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kava. Even though Kava itself has no known interaction with Lanadelumab (Shp643), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kava and Lanadelumab (Shp643) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kava
Top 25%

#284 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lanadelumab (Shp643)
Top 10%

#258 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kava reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Kava and Lanadelumab (Shp643) records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Kava

What is Kava?

Kava
  • Anxiety and stress
  • Restlessness
  • Trouble sleeping
  • Relaxation in social or cultural settings
  • Menopausal symptoms

Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However, kava has been linked to rare but serious liver damage, so it should be used with caution, avoided by people with liver problems, and only used after talking with your pharmacist or doctor.

Piper methysticum · Piperaceae · Roots and rhizomes · Capsules, tablets, liquid extracts, tinctures, teas, and traditional water-based root drinks

An interaction check asks whether these two react with each other — it does not ask whether Kava is a good idea for someone in your situation. Here is what our Kava record says about it on its own.

Kava: dosing

There is no single established or standardized dose for kava, and products vary widely in how much kavalactone they contain. Because of this and the risk of liver harm, it is best not to guess at a dose on your own.If you and your healthcare provider decide kava is appropriate, follow the directions on the product label and use the lowest effective amount for the shortest time. Many experts advise limiting how long you use kava.

From our Kava monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kava monograph & all interactions
Medication

About Lanadelumab-flyo injection

What Is Lanadelumab-flyo injection Used For?

Brand name: Takhzyro

Takhzyro (lanadelumab-flyo) is used to prevent attacks of hereditary angioedema (HAE) — a condition that causes sudden, painful episodes of swelling in areas like the skin, abdomen, hands, feet, and throat. It is approved for adults and children 2 years of age and older.

Takhzyro is a preventive (prophylactic) therapy. It is not used to treat an attack that is already happening — it works in the background to reduce how often attacks occur.

See full Lanadelumab-flyo injection drug information
Keep checking

Other Drugs & Kava

Browse every other medication we’ve checked against Kava — both the ones with a known interaction and the ones without. Select any drug for the full detail.

248Major
577Moderate
341Minor
1,663No known interaction
248 Major 577 Moderate 341 Minor 1,663 No interaction
Major

248 interactions

Showing 60 of 248 major interactions — see all 248 on the Kava page.

Moderate

577 interactions

Showing 60 of 577 moderate interactions — see all 577 on the Kava page.

Minor

341 interactions

Showing 60 of 341 minor interactions — see all 341 on the Kava page.

No interaction 1,663 drugs checked — show the list

We also checked Kava against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,663 medications checked with no known interaction — see the full Kava list.

See the full Kava interactions page
See every supplement checked against Lanadelumab (Shp643), ranked by severity
Evidence & sources

Kava References

The 71 references that drive our Kava monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Strahl S, Ehret V, Dahm HH, Maier KP. [Necrotizing hepatitis after taking herbal medication]. Dtsch Med Wochenschr 1998;123:1410-4.
  3. Spillane PK, et al. Neurological manifestations of kava intoxication. Med J Aust 1997;167:172-3. PubMed
  4. Swensen JN. Man convicted of driving under the influence of kava. Salt Lake City, UT: Deseret News, 1996.
  5. Pittler MH, Ernst E. Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. J Clin Psychopharmacol 2000;20:84-9. PubMed
  6. Volz HP, Kieser M. Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25-week outpatient trial. Pharmacopsychiatry 1997;30:1-5. PubMed
  7. Heinze HJ, Munthe TF, Steitz J, Matzke M. Pharmacopsychological effects of oxazepam and kava-extract in a visual search paradigm assessed with event-related potentials. Pharmacopsychiatry 1994;27:224-30. PubMed
  8. Munte TF, Heinze HJ, Matzke M, Steitz J. Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. Neuropsychobiology 1993;27:46-53.
  9. Wheatley D. Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum Psychopharmacol 2001;16:353-6. PubMed
  10. Schelosky L, Raffaup C, Jendroska K, Poewe W. Kava and dopamine antagonism. J Neurol Neurosurg Psychiatry 1995;58:639-40. PubMed
  11. Norton SA, Ruze P. Kava dermopathy. J Am Acad Dermatol 1994;31:89-97.
  12. Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. 2nd ed. Edinburgh:Churchill Livingstone, 1999.
  13. Mathews JD, Riley MD, Fejo L, et al. Effects of heavy usage of kava on physical health: Summary of a pilot survey in an aboriginal community. Med J Aust 1988;148:548-55.
  14. Escher M, Desmeules J, Giostra E, Mentha G. Hepatitis associated with Kava, a herbal remedy for anxiety. BMJ 2001;322:139.
  15. Russmann S, Lauterburg BH, Helbling A. Kava hepatotoxicity [letter]. Ann Intern Med 2001;135:68-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Kava and Lanadelumab (Shp643) Together: Common Questions

Is it safe to take Kava with Lanadelumab (Shp643)?
We do not list a known interaction between Kava and Lanadelumab (Shp643). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Kava and Lanadelumab (Shp643) have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Kava interact with any other medications?
Yes. Kava has 1,166 documented drug interactions in our database — Lanadelumab (Shp643) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Kava monograph Uses, safety profile, and every drug interaction in one place Lanadelumab-flyo injection drug information The full plain-English guide to this medication Lanadelumab (Shp643) supplement interactions Every supplement checked against Lanadelumab (Shp643), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 71 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lanadelumab (Shp643) and Kava?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.