Drug & supplement interaction

Yohimbe + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Yohimbe and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Yohimbe and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Yohimbe in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yohimbe safety at a glance

Yohimbe overall Use caution Yohimbe can cause serious heart and blood pressure effects and supplement potency is unpredictable.
Pregnancy Possibly Unsafe When used orally. Yohimbe might have uterine relaxant effects and also cause fetal toxicity. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Yohimbe might have uterine relaxant effects and also cause fetal toxicity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Yohimbe? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefaclor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefaclor is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Yohimbe has documented interactions with 13 drug classes — the most serious being monoamine oxidase inhibitors (maois) (major), antihypertensive drugs (moderate) and clonidine (catapres) (moderate) — and none of Cefaclor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Yohimbe Does Interact With Other Medications

Yohimbe has 9 major, 680 moderate, 436 minor known drug interactions in our database — Cefaclor isn’t one of them. If you take anything else, check it against the full list below.

Major 9 Moderate 680 Minor 436 No known interaction 1,705 (incl. Cefaclor)
Taking anything else?

Check Another of Your Medications Against Yohimbe

Covers the 2,830 medications we’ve checked against Yohimbe. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Yohimbe and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • Fainting Worth acting on Additional detail

    Yohimbe

    “Orally, yohimbine, a constituent of yohimbe, has been associated with reports of general central nervous system (CNS) and autonomic excitation, tremulousness, head twitching, seizure threshold changes, enhanced brain norepinephrine release, decreased energy, dizziness, vertigo, and headache. Cold feet and chills have also been reported with yohimbine. Other adverse reactions include flushing and diaphoresis.”

    Yohimbe · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    2. 3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
    3. 86774. Cameron, O. G., Zubieta, J. K., Grunhaus, L., and Minoshima, S. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom.Med 2000;62(4):549-559. PubMed
    4. 86779. Bowes, M. P., Peters, R. H., Kernan, W. J., Jr., and Hopper, D. L. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol.Biochem.Behav. 1992;41(4):707-713.
    5. 86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
    6. 86804. Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Wheezing Worth acting on Additional detail

    Yohimbe

    “Orally, yohimbine, a constituent of yohimbe, may cause bronchospasm, tachypnea, cough, and rhinorrhea. A case of sinusitis characterized by pain and discomfort above both eyes has been reported for a 59-year-old male taking yohimbine 5.4 mg three times daily to treat erectile dysfunction. Symptoms resolved within 24 hours of discontinuing yohimbine.”

    Yohimbe · Natural Medicines adverse-effect record, reported in cough.

    5 sources cited
    1. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    2. 86825. Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
    3. 86850. Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
    4. 94112. Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
    5. 1118. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Chest pain Worth acting on Additional detail

    Yohimbe

    “Orally, yohimbine, a constituent of yohimbe, has been associated with hypertension, especially at higher doses. A case of hypertensive crisis was reported in a 63-year-old male taking a yohimbine-containing herbal product once daily for one month. The patient was successfully managed with intravenous nitroprusside followed by clonidine.”

    Yohimbe · Natural Medicines adverse-effect record, reported in atrial fibrillation.

    6 sources cited
    1. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    2. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    3. 86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
    4. 86802. Bloomer, R. J., Canale, R. E., Blankenship, M. M., Hammond, K. G., Fisher-Wellman, K. H., and Schilling, B. K. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized,
    5. 86804. Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
    6. 86811. Shibao, C., Okamoto, L. E., Gamboa, A., Yu, C., Diedrich, A., Raj, S. R., Robertson, D., and Biaggioni, I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010;56(5) PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Yohimbe

    “There is one report of a hypersensitivity reaction including fever; chills; malaise; itchy, scaly skin; progressive renal failure; and lupus-like syndrome associated with ingestion of a one-day dose of yohimbine, a constituent of yohimbe.”

    Yohimbe · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed

    “Orally, yohimbine, a constituent of yohimbe, may increase urinary frequency. A case of acute renal failure has been reported for a 42-year-old male taking yohimbine. Normalization of renal function was achieved following 2 weeks of treatment with corticosteroids. The renal dysfunction was attributed to yohimbine-induced systemic lupus erythematosus.”

    Yohimbe · Natural Medicines adverse-effect record, reported in kidney failure.

    6 sources cited
    1. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    2. 3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
    3. 3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
    4. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    5. 86804. Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
    6. 86827. Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Yohimbe

    Recorded for Yohimbe in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Passing urine more often Additional detail

    Yohimbe

    “Orally, there is limited information available about the adverse effects of yohimbe. Yohimbine, a constituent of yohimbe, might be unsafe; most reported adverse effects are dose-related.

    Most Common Adverse Effects:

    Orally: Yohimbine, a constituent of yohimbe, has been associated with anxiety, agitation, diaphoresis, diarrhea, flushing, headache, hypertension, increased urination, nausea, tachycardia, tremors, vertig…”

    Yohimbe · Natural Medicines adverse-effect record, reported in anxiety.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Chills Additional detail

    Yohimbe

    Recorded for Yohimbe in the same Natural Medicines adverse-effect record shown under Fainting above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Sweating Additional detail

    Yohimbe

    Recorded for Yohimbe in the same Natural Medicines adverse-effect record shown under Passing urine more often above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Cough Additional detail

    Yohimbe

    Recorded for Yohimbe in the same Natural Medicines adverse-effect record shown under Wheezing above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Yohimbe

    “Orally, yohimbine, a constituent of yohimbe, may increase malaise, fatigue, insomnia, restlessness, agitation, and anxiety. In a clinical study of healthy subjects, administration of yohimbine increased impulsivity, with larger doses increasing impulsivity more than 50%.”

    Yohimbe · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    2. 3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
    3. 3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
    4. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    5. 86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
    6. 86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Showing the 10 most notable of 20 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Yohimbe but not commonly for Cefaclor: a heart attack, erection problems, an irregular heartbeat and raised blood pressure.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Yohimbe come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Yohimbe in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Yohimbe might have uterine relaxant effects and also cause fetal toxicity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cefaclor Products Have a Food Rule — Yohimbe Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Yohimbe on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Yohimbe only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

One more smart check

Taking Yohimbe as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,054 real supplement products containing Yohimbe, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yohimbe. Even though Yohimbe itself has no known interaction with Cefaclor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yohimbe and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yohimbe
Top 25%

#173 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#219 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yohimbe reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Yohimbe and Cefaclor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yohimbe

What is Yohimbe?

Yohimbe
  • Erectile dysfunction
  • Low sex drive
  • Sexual performance
  • Weight loss
  • Athletic performance

Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for erectile dysfunction, but over-the-counter yohimbe supplements vary widely in content and can cause serious side effects like high blood pressure and fast heart rate. Because of these safety concerns, talk to your pharmacist or doctor before using it.

Pausinystalia johimbe · Rubiaceae · Bark · Capsules, tablets, extracts, teas

An interaction check asks whether these two react with each other — it does not ask whether Yohimbe is a good idea for someone in your situation. Here is what our Yohimbe record says about it on its own.

Yohimbe: dosing

There is no well-established safe and standardized dose for yohimbe bark supplements. Because the yohimbine content varies so much between products, the same labeled dose can produce very different effects.If you choose to use a product, follow the directions on the label and do not exceed them. Prescription yohimbine is a separate, dose-controlled medicine and should only be used as directed by a healthcare provider.

From our Yohimbe monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yohimbe monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. Cefaclor capsules and oral suspension are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

Cefaclor extended-release tablets are approved for a narrower set of uses in adults: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin and skin structure infections. Not all formulations are approved for the same conditions, so the form matters.

See full Cefaclor drug information
Keep checking

Other Drugs & Yohimbe

Browse every other medication we’ve checked against Yohimbe — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
680Moderate
436Minor
1,704No known interaction
9 Major 680 Moderate 436 Minor 1,704 No interaction
Major

9 interactions

Moderate

680 interactions

Showing 60 of 680 moderate interactions — see all 680 on the Yohimbe page.

Minor

436 interactions

Showing 60 of 436 minor interactions — see all 436 on the Yohimbe page.

No interaction 1,704 drugs checked — show the list

We also checked Yohimbe against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,704 medications checked with no known interaction — see the full Yohimbe list.

See the full Yohimbe interactions page
See every supplement checked against Cefaclor, ranked by severity
Evidence & sources

Yohimbe References

The 66 references that drive our Yohimbe monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  6. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  7. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
  8. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
  9. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
  10. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
  11. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
  12. Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent.Hyg. 2003;77(1):37-46.
  13. Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
  14. Cameron, O. G., Zubieta, J. K., Grunhaus, L., and Minoshima, S. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom.Med 2000;62(4):549-559. PubMed
  15. Bowes, M. P., Peters, R. H., Kernan, W. J., Jr., and Hopper, D. L. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol.Biochem.Behav. 1992;41(4):707-713.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Yohimbe and Cefaclor Together: Common Questions

Is it safe to take Yohimbe with Cefaclor?
We do not list a known interaction between Yohimbe and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Yohimbe and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Yohimbe and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Yohimbe on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Yohimbe and Cefaclor combination checked?
Interactions in our licensed database are recorded against drug classes. Cefaclor is filed under 6 classifications, and Yohimbe has documented interactions with 13 drug classes — none of Cefaclor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Yohimbe interact with any other medications?
Yes. Yohimbe has 1,125 documented drug interactions in our database — Cefaclor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Yohimbe is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Yohimbe monograph Uses, safety profile, and every drug interaction in one place Cefaclor drug information The full plain-English guide to this medication Cefaclor supplement interactions Every supplement checked against Cefaclor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 66 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefaclor and Yohimbe?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.