Medication interaction hub

What Supplements Interact with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Acetaminophen, Diphenhydramine, Pseudoephedrine brand names: Contac Night Allergy Relief, Children's Tylenol Allergy, Cold Control. Every interaction below applies to the brands too.

292 Interactions 15 Major 234 Moderate 43 Minor

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A drink with this medicine is the risk I would flag first. Beer and wine both carry major ratings, well documented in humans, because alcohol deepens the sedation that diphenhydramine already causes. That theme runs through much of the file for acetaminophen, diphenhydramine, and pseudoephedrine (Contac Night Allergy Relief, Children's Tylenol Allergy), where 78 of the 292 ingredients on record add to drowsiness, kava among the worst. With 15 entries rated major, this combination calls for real vigilance about what you take alongside it.

The other major concerns pull in different directions. Pseudoephedrine is a stimulant, so 44 ingredients, ephedra among them, can drive blood pressure and heart strain higher. Thirty add to diphenhydramine's drying anticholinergic effects, and 38 can stress the liver alongside acetaminophen. Most of the remaining 234 moderate and 43 minor entries involve gentler shifts in how the drugs are processed. Activated charcoal is its own problem, since it can soak up the medicine before your body absorbs it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Diphenhydramine, Pseudoephedrine: Top Interactions at a Glance

The Acetaminophen, Diphenhydramine, Pseudoephedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 292 interacting ingredients — plus 1,160 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Diphenhydramine, Pseudoephedrine Combinations Today

The Acetaminophen, Diphenhydramine, Pseudoephedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

The complete list

Every Supplement Checked Against Acetaminophen, Diphenhydramine, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 292 with a Acetaminophen, Diphenhydramine, Pseudoephedrine interaction on file and 1,160 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Straight answers

Can You Take It With Acetaminophen, Diphenhydramine, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alfalfa with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Gamma-aminobutyric Acid (gaba) with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Baikal Skullcap with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Full Baikal Skullcap + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Butcher's Broom with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Kava with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Lavender with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Thyroid Extract with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Hibiscus Sabdariffa with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.

Full Hibiscus Sabdariffa + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Vitamin C with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Agar with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Algin with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Aloe with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Anise with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.

Full Anise + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Atractylodes with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Bael with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Beet with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Black Pepper with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Full Black Pepper + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Black Psyllium with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Blond Psyllium with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Acetaminophen, Diphenhydramine, Pseudoephedrine answer

Can you take Broccoli Sprout with Acetaminophen, Diphenhydramine, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.

Full Broccoli Sprout + Acetaminophen, Diphenhydramine, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Diphenhydramine, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Diphenhydramine, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Diphenhydramine, Pseudoephedrine sits in 16 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Diphenhydramine, Pseudoephedrine through this category.

Related: does Acetaminophen, Diphenhydramine, Pseudoephedrine deplete any nutrients?

Acetaminophen, Diphenhydramine, Pseudoephedrine has 3 reported nutrient associations in the research literature — see the Acetaminophen, Diphenhydramine, Pseudoephedrine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Diphenhydramine, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Diphenhydramine, Pseudoephedrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Acetaminophen, Diphenhydramine, Pseudoephedrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Diphenhydramine, Pseudoephedrine.

Pharmacist Counseling Corner

Acetaminophen, Diphenhydramine, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Acetaminophen, Diphenhydramine, Pseudoephedrine?
More than you might expect — 292 in total, though they are far from equal: 15 are rated major, 234 moderate, and 43 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Acetaminophen, Diphenhydramine, Pseudoephedrine supplement interactions are the most serious?
The 15 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Diphenhydramine, Pseudoephedrine?
Usually yes — most people on Acetaminophen, Diphenhydramine, Pseudoephedrine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Contac Night Allergy Relief have the same supplement interactions as Acetaminophen, Diphenhydramine, Pseudoephedrine?
Yes — Contac Night Allergy Relief, Children's Tylenol Allergy, Cold Control all contain Acetaminophen, Diphenhydramine, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Diphenhydramine, Pseudoephedrine deplete any vitamins or nutrients?
It might — Acetaminophen, Diphenhydramine, Pseudoephedrine has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Diphenhydramine, Pseudoephedrine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Diphenhydramine, Pseudoephedrine and my other medications?
This page covers Acetaminophen, Diphenhydramine, Pseudoephedrine against supplements and herbal ingredients. Checking Acetaminophen, Diphenhydramine, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.