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What Supplements Interact with Belladonna, Ergotamine, Phenobarbital?

Belladonna, Ergotamine, Phenobarbital brand name: Bellergal-S. Every interaction below applies to the brands too.

250 Interactions 11 Major 200 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belladonna, Ergotamine, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belladonna, Ergotamine, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bellergal-S packs three drugs into one tablet, and its supplement list earns real respect before you mix in anything else. Phenobarbital is a sedating barbiturate, belladonna adds drying anticholinergic effects, and ergotamine constricts blood vessels, so this combination collects interactions from several directions at once. Most of the 250 entries fall into two big camps: 78 ingredients that deepen sedation the way alcohol does, and a larger group tied to the CYP3A4 enzyme, which grapefruit can block enough to raise drug levels.

Eleven of the 250 rate major, and those deserve your attention first. St. John's wort runs the opposite direction, speeding phenobarbital's breakdown so the drug may stop working as well. Another 30 ingredients add to belladonna's drying effects, meaning dry mouth, blurred vision, and constipation. The remaining 200 moderate and 39 minor entries matter less urgently, but a list this long is worth reading closely rather than skimming.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 200 Minor 39 No known interaction 1,202

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Belladonna, Ergotamine, Phenobarbital: Top Interactions at a Glance

The most significant Belladonna, Ergotamine, Phenobarbital supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Belladonna, Ergotamine, Phenobarbital + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Belladonna, Ergotamine, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Belladonna, Ergotamine, Phenobarbitali

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely St. John's Wort + Belladonna, Ergotamine, Phenobarbitali

St.

Read the full interaction Major Likelihood Likely Wine + Belladonna, Ergotamine, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Belladonna, Ergotamine, Phenobarbitali

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Belladonna, Ergotamine, Phenobarbitali

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Belladonna, Ergotamine, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 250 with a Belladonna, Ergotamine, Phenobarbital interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belladonna, Ergotamine, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Tragacanth with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bay Leaf with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Belladonna, Ergotamine, Phenobarbital answer

Can you take Butterbur with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bacopa with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Belladonna, Ergotamine, Phenobarbital answer

Can you take Beet with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Belladonna, Ergotamine, Phenobarbital answer

Can you take Berberine with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Belladonna, Ergotamine, Phenobarbital answer

Can you take Beta-methylphenethylamine (bmpea) with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bishop's Weed with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bitter Almond with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bitter Orange with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Belladonna, Ergotamine, Phenobarbital answer

Can you take Black Pepper with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Belladonna, Ergotamine, Phenobarbital answer

Can you take Black Seed with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Belladonna, Ergotamine, Phenobarbital answer

Can you take Black Tea with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Black Tea + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bog Labrador Tea with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Belladonna, Ergotamine, Phenobarbital answer

Can you take Boneset with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Belladonna, Ergotamine, Phenobarbital answer

Can you take Borage with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Full Borage + Belladonna, Ergotamine, Phenobarbital answer

Can you take Boswellia Serrata with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Belladonna, Ergotamine, Phenobarbital answer

Can you take Boxwood with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Belladonna, Ergotamine, Phenobarbital answer

Can you take Bulbine Natalensis with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Belladonna, Ergotamine, Phenobarbital answer

Can you take Caffeine with Belladonna, Ergotamine, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Caffeine + Belladonna, Ergotamine, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belladonna, Ergotamine, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belladonna, Ergotamine, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belladonna, Ergotamine, Phenobarbital sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Belladonna, Ergotamine, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Belladonna, Ergotamine, Phenobarbital through this category.

Related: does Belladonna, Ergotamine, Phenobarbital deplete any nutrients?

Belladonna, Ergotamine, Phenobarbital has 7 reported nutrient associations in the research literature — see the Belladonna, Ergotamine, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belladonna, Ergotamine, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belladonna, Ergotamine, Phenobarbital.

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Pharmacist Counseling Corner

Belladonna, Ergotamine, Phenobarbital & Supplements: Common Questions

What supplements interact with Belladonna, Ergotamine, Phenobarbital?
Our database currently documents 250 ingredients with a known Belladonna, Ergotamine, Phenobarbital interaction (11 major, 200 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 250. The highest-ranked right now: Beer, Grapefruit, St. John's Wort.
Which Belladonna, Ergotamine, Phenobarbital supplement interactions are the most serious?
The 11 major-rated combinations — led by Beer, Grapefruit, St. John's Wort, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Belladonna, Ergotamine, Phenobarbital?
Plenty of supplements coexist fine with Belladonna, Ergotamine, Phenobarbital; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Bellergal-S have the same supplement interactions as Belladonna, Ergotamine, Phenobarbital?
Yes — Bellergal-S all contain Belladonna, Ergotamine, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Belladonna, Ergotamine, Phenobarbital deplete any vitamins or nutrients?
It might — Belladonna, Ergotamine, Phenobarbital has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Belladonna, Ergotamine, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Belladonna, Ergotamine, Phenobarbital and my other medications?
This page covers Belladonna, Ergotamine, Phenobarbital against supplements and herbal ingredients. Checking Belladonna, Ergotamine, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.