Felbamate

199 interactions 345 cited references

Also sold as: Felbatol Felbatol®

About Felbamate

Felbamate is used to treat certain seizures in adults and children with epilepsy whose seizures have not improved with other treatments. It is used alone or in combination with other medications to treat partial seizures in adults. It is used in combination with other medications to treat partial and generalized seizur… Read the full Felbamate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Thioridazine Sparfloxacin Terfenadine Ziprasidone Bepridil Saquinavir

12 Contraindicated 179 Major 8 Moderate

All (199) Contraindicated (12) Major (179) Moderate (8)

Contraindicated

Felbamate Bepridil An increased risk of QT interval prolongation Details Felbamate Cisapride Propulsid® Increased risk of QT interval prolongation Details Felbamate Dronedarone Multaq Increased risk of QT interval prolongation Details Felbamate Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Felbamate Mesoridazine An increased risk of QT interval prolongation Details Felbamate Pimozide An increased risk of QT interval prolongation and an increased risk of seizure Details Felbamate Piperaquine An increased risk of QT interval prolongation Details Felbamate Saquinavir An increased risk of QT interval prolongation Details Felbamate Sparfloxacin An increased risk of QT interval prolongation Details Felbamate Terfenadine An increased risk of QT interval prolongation Details Felbamate Thioridazine An increased risk of QT interval prolongation Details Felbamate Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Felbamate Sertraline An increased risk of QT interval prolongation Details Felbamate Buprenorphine Belbuca An increased risk of QT interval prolongation Details Felbamate Relugolix Orgovyx Increased risk of QT interval prolongation Details Felbamate Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Felbamate Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Felbamate Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Felbamate Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Felbamate Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Felbamate Azathioprine Azasan An increased risk of hepatotoxicity Details Felbamate Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Felbamate Anagrelide Agrylin Increased risk of QT interval prolongation Details Felbamate Bedaquiline Sirturo Increased risk of QT interval prolongation Details Felbamate Calcifediol Rayaldee Altered serum levels of calcifediol Details Felbamate Chloroquine Aralen® Increased risk of QT-interval prolongation Details Felbamate Dasatinib Phyrago An increased risk of QT interval prolongation Details Felbamate Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Felbamate Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Felbamate Dofetilide Tikosyn An increased risk of QT interval prolongation Details Felbamate Encorafenib Braftovi Increased risk of QT interval prolongation Details Felbamate Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Felbamate Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Felbamate Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Felbamate Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Felbamate Apomorphine Apokyn Increased risk of QT interval prolongation Details Felbamate Aripiprazole Abilify An increased risk of QT interval prolongation Details Felbamate Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Felbamate Artemether An increased risk of QT interval prolongation Details Felbamate Asenapine Saphris Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.