Naproxen

309 interactions 807 cited references
Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen
About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab
4 Contraindicated 228 Major 66 Moderate 11 Minor
All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.