Norgestrel

46 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Octreotide Colesevelam Penicillin V Potassium Meropenem Injection Bexarotene Topical
40 Major 6 Moderate
All (46) Major (40) Moderate (6)

Major

Norgestrel Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Norgestrel Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Norgestrel Ampicillin Amcill® Decreased contraceptive effectiveness Details Norgestrel Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Norgestrel Bexarotene Targretin Decreased contraceptive effectiveness Details Norgestrel Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Norgestrel Cefaclor Ceclor® Decreased contraceptive effectiveness Details Norgestrel Cefadroxil Duricef® Decreased contraceptive effectiveness Details Norgestrel Cefdinir Omnicef® Decreased contraceptive effectiveness Details Norgestrel Cefixime Suprax Decreased contraceptive effectiveness Details Norgestrel Cefprozil Cefzil® Decreased contraceptive effectiveness Details Norgestrel Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Norgestrel Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Norgestrel Colesevelam Welchol Decreased contraceptive effectiveness Details Norgestrel Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norgestrel Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norgestrel Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norgestrel Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norgestrel Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Norgestrel Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Norgestrel Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Norgestrel Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Norgestrel Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Norgestrel Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norgestrel Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norgestrel Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Norgestrel Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Norgestrel Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norgestrel Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norgestrel Methylergonovine Methergine Increased methylergonovine exposure Details Norgestrel Minocycline Amzeeq Decreased contraceptive efficacy Details Norgestrel Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Norgestrel Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Norgestrel Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Norgestrel Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Norgestrel Nifedipine Adalat® Increased NIFEdipine exposure Details Norgestrel Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norgestrel Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norgestrel Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details Norgestrel Penicillin V Potassium Beepen-VK® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.