Medication interaction hub

What Supplements Interact with Alogliptin, Pioglitazone?

Alogliptin, Pioglitazone brand name: Oseni. Every interaction below applies to the brands too.

356 Interactions 6 Major 309 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Alogliptin, Pioglitazone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Alogliptin, Pioglitazone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone taking Oseni (alogliptin and pioglitazone) for type 2 diabetes often shops the very shelf this list comes from, and the pairing deserves genuine caution. Of the 356 ingredients on file, 239 also lower blood sugar, so stacking them on top of the pill can drop glucose too far. Six entries rate as major, and grapefruit tops them: it raises the drug's blood levels and, with them, the chance of side effects, while St. John's wort does the reverse and can weaken the medication.

Most of the 309 moderate entries repeat that additive blood-sugar effect, and the 41 minor ones matter less, so more frequent glucose checks cover the widest slice of this list. The other major concerns pull toward the liver, which pioglitazone already taxes; 38 ingredients, heavy beer or wine included, add strain there. A few, activated charcoal among them, can keep the pill from absorbing at all, so space those doses well apart.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 309 Minor 41 No known interaction 1,096

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Alogliptin, Pioglitazone: Top Interactions at a Glance

The Alogliptin, Pioglitazone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 356 interacting ingredients — plus 1,096 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Alogliptin, Pioglitazone Combinations Today

The Alogliptin, Pioglitazone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Colocynth + Alogliptin, Pioglitazonei

Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Probable Banaba + Alogliptin, Pioglitazonei

Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Alogliptin, Pioglitazonei

Theoretically, concomitant use might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Chicory + Alogliptin, Pioglitazonei

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Rhodiola + Alogliptin, Pioglitazonei

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Horsetail + Alogliptin, Pioglitazonei

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Alogliptin, Pioglitazone

All 1,452 ingredients in our database, ranked by severity — 356 with a Alogliptin, Pioglitazone interaction on file and 1,096 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Alogliptin, Pioglitazone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Colocynth with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Colocynth + Alogliptin, Pioglitazone answer

Can you take Banaba with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Alogliptin, Pioglitazone answer

Can you take Red Yeast Rice with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Alogliptin, Pioglitazone answer

Can you take Chicory with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Alogliptin, Pioglitazone answer

Can you take Rhodiola with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Full Rhodiola + Alogliptin, Pioglitazone answer

Can you take Inulin with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.

Full Inulin + Alogliptin, Pioglitazone answer

Can you take Mommy's Bliss Gripe Water with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Alogliptin, Pioglitazone answer

Can you take Polypodium Leucotomos with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Alogliptin, Pioglitazone answer

Can you take Pomegranate with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Alogliptin, Pioglitazone answer

Can you take Red Clover with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Alogliptin, Pioglitazone answer

Can you take Tangerine with Alogliptin, Pioglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Alogliptin, Pioglitazone answer

Can you take Grapefruit with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Alogliptin, Pioglitazone answer

Can you take Siberian Cocklebur with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the liver.

Full Siberian Cocklebur + Alogliptin, Pioglitazone answer

Can you take Activated Charcoal with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Alogliptin, Pioglitazone answer

Can you take Beer with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Alogliptin, Pioglitazone answer

Can you take St. John's Wort with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Alogliptin, Pioglitazone answer

Can you take Wine with Alogliptin, Pioglitazone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Alogliptin, Pioglitazone answer

Can you take American Ginseng with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full American Ginseng + Alogliptin, Pioglitazone answer

Can you take Astragalus with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Astragalus + Alogliptin, Pioglitazone answer

Can you take Bitter Melon with Alogliptin, Pioglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Alogliptin, Pioglitazone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Alogliptin, Pioglitazone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Alogliptin, Pioglitazone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Alogliptin, Pioglitazone sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Pioglitazone (Actos) 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Alogliptin, Pioglitazone through this category.

Related: does Alogliptin, Pioglitazone deplete any nutrients?

Alogliptin, Pioglitazone has 1 reported nutrient association in the research literature — see the Alogliptin, Pioglitazone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Alogliptin, Pioglitazone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Alogliptin, Pioglitazone.

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Pharmacist Counseling Corner

Alogliptin, Pioglitazone & Supplements: Common Questions

What supplements interact with Alogliptin, Pioglitazone?
More than you might expect — 356 in total, though they are far from equal: 6 are rated major, 309 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Alogliptin, Pioglitazone supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Alogliptin, Pioglitazone?
Usually yes — most people on Alogliptin, Pioglitazone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Oseni have the same supplement interactions as Alogliptin, Pioglitazone?
Yes — Oseni all contain Alogliptin, Pioglitazone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Alogliptin, Pioglitazone deplete any vitamins or nutrients?
It might — Alogliptin, Pioglitazone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Alogliptin, Pioglitazone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Alogliptin, Pioglitazone and my other medications?
This page covers Alogliptin, Pioglitazone against supplements and herbal ingredients. Checking Alogliptin, Pioglitazone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.