Medication interaction hub

What Supplements Interact with Sotagliflozin?

Sotagliflozin brand name: Inpefa. Every interaction below applies to the brands too.

265 Interactions 2 Major 223 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sotagliflozin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sotagliflozin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take sotagliflozin (Inpefa) for heart failure or diabetes, read this list carefully before adding any supplement, and start with the two rated major. Siberian cocklebur has caused severe low blood sugar in humans, and activated charcoal can pull the drug out of your system before it does its job. Most of the other 263 entries, including 223 rated moderate, share one theme: they affect blood sugar control, usually pushing it lower alongside sotagliflozin and raising your odds of a low.

A smaller group acts on the pill itself. Fiber supplements and charcoal products can block its absorption, so space them well apart from your dose, and a handful of foods like cabbage may speed how your body clears drugs like this one. Only 40 entries are minor. Because Inpefa is often prescribed for the heart rather than diabetes, a supplement-driven glucose drop can catch you unprepared, so test more often whenever a new bottle appears in your cabinet.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 223 Minor 40 No known interaction 1,187

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Sotagliflozin: Top Interactions at a Glance

The Sotagliflozin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 265 interacting ingredients — plus 1,187 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Sotagliflozin Combinations Today

The Sotagliflozin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Coffee + Sotagliflozini

Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Sotagliflozini

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Horsetail + Sotagliflozini

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Terminalia + Sotagliflozini

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of h...

Read the full interaction Moderate Likelihood Possible Black Pepper + Sotagliflozini

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Minor Likelihood Possible Agar + Sotagliflozini

Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Read the full interaction
The complete list

Every Supplement Checked Against Sotagliflozin

All 1,452 ingredients in our database, ranked by severity — 265 with a Sotagliflozin interaction on file and 1,187 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sotagliflozin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Full Coffee + Sotagliflozin answer

Can you take Bitter Orange with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Bitter Orange + Sotagliflozin answer

Can you take Horsetail with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Full Horsetail + Sotagliflozin answer

Can you take Terminalia with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and in...

Full Terminalia + Sotagliflozin answer

Can you take Black Pepper with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Pepper + Sotagliflozin answer

Can you take White Horehound with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.

Full White Horehound + Sotagliflozin answer

Can you take White Mulberry with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Sotagliflozin answer

Can you take White Pepper with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that piperine, a constituent of white pepper, reduces blood glucose levels.

Full White Pepper + Sotagliflozin answer

Can you take Winter Cherry with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Sotagliflozin answer

Can you take Zeaxanthin with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Zeaxanthin + Sotagliflozin answer

Can you take Zizyphus with Sotagliflozin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Zizyphus + Sotagliflozin answer

Can you take Thyroid Extract with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Sotagliflozin answer

Can you take Anhydrous Crystalline Maltose with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose)...

Full Anhydrous Crystalline Maltose + Sotagliflozin answer

Can you take Agar with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Sotagliflozin answer

Can you take Algin with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Sotagliflozin answer

Can you take Apple Cider Vinegar with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Sotagliflozin answer

Can you take Black Psyllium with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Sotagliflozin answer

Can you take Blond Psyllium with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Sotagliflozin answer

Can you take Calea Zacatechichi with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.

Full Calea Zacatechichi + Sotagliflozin answer

Can you take Carob with Sotagliflozin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Sotagliflozin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sotagliflozin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sotagliflozin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sotagliflozin sits in 3 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Sotagliflozin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sotagliflozin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Sotagliflozin through this category.

Related: does Sotagliflozin deplete any nutrients?

Sotagliflozin has 1 reported nutrient association in the research literature — see the Sotagliflozin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sotagliflozin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sotagliflozin.

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Pharmacist Counseling Corner

Sotagliflozin & Supplements: Common Questions

What supplements interact with Sotagliflozin?
More than you might expect — 265 in total, though they are far from equal: 2 are rated major, 223 moderate, and 40 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Sotagliflozin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Sotagliflozin?
Usually yes — most people on Sotagliflozin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Inpefa have the same supplement interactions as Sotagliflozin?
Yes — Inpefa all contain Sotagliflozin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Sotagliflozin deplete any vitamins or nutrients?
It might — Sotagliflozin has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Sotagliflozin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Sotagliflozin and my other medications?
This page covers Sotagliflozin against supplements and herbal ingredients. Checking Sotagliflozin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.