Naproxen

309 interactions 807 cited references

Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen

About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab

4 Contraindicated 228 Major 66 Moderate 11 Minor

All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Major

Naproxen Bufexamac Increased risk of bleeding Details Naproxen Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Cangrelor Kengreal An increased risk of bleeding Details Naproxen Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Naproxen Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Naproxen Certoparin An increased risk of bleeding Details Naproxen Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Naproxen Choline Salicylate Increased risk of bleeding Details Naproxen Cilostazol Pletal® An increased risk of bleeding Details Naproxen Citalopram Celexa An increased risk of bleeding Details Naproxen Clomipramine Anafranil An increased risk of bleeding Details Naproxen Clonixin Increased risk of bleeding Details Naproxen Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Naproxen Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Dalteparin Fragmin An increased risk of bleeding Details Naproxen Danaparoid An increased risk of bleeding Details Naproxen Desipramine Norpramin An increased risk of bleeding Details Naproxen Desirudin Iprivask An increased risk of bleeding Details Naproxen Desvenlafaxine Pristiq An increased risk of bleeding Details Naproxen Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Dexibuprofen Increased risk of bleeding Details Naproxen Dexketoprofen Increased risk of bleeding Details Naproxen Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Dibenzepin An increased risk of bleeding Details Naproxen Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Naproxen Diflunisal Dolobid Increased risk of bleeding Details Naproxen Dipyrone Increased risk of bleeding Details Naproxen Dothiepin An increased risk of bleeding Details Naproxen Doxepin Prudoxin An increased risk of bleeding Details Naproxen Droxicam Increased risk of bleeding Details Naproxen Duloxetine An increased risk of bleeding Details Naproxen Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Naproxen Eptifibatide An increased risk of bleeding Details Naproxen Escitalopram Lexapro An increased risk of bleeding Details Naproxen Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Etofenamate Increased risk of bleeding Details

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