Naproxen

309 interactions 807 cited references

Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen

About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab

4 Contraindicated 228 Major 66 Moderate 11 Minor

All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Major

Naproxen Etoricoxib Increased risk of bleeding Details Naproxen Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Felbinac Increased risk of bleeding Details Naproxen Fepradinol Increased risk of bleeding Details Naproxen Feprazone Increased risk of bleeding Details Naproxen Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Naproxen Floctafenine Increased risk of bleeding Details Naproxen Flufenamic Acid Increased risk of bleeding Details Naproxen Fluoxetine RECONCILE An increased risk of bleeding Details Naproxen Fluvoxamine An increased risk of bleeding Details Naproxen Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Gossypol Increased risk of adverse gastrointestinal effects Details Naproxen Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Imipramine An increased risk of bleeding Details Naproxen Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Indomethacin Indocin Increased risk of bleeding Details Naproxen Inotersen Increased risk of bleeding Details Naproxen Lepirudin An increased risk of bleeding Details Naproxen Levomilnacipran An increased risk of bleeding Details Naproxen Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Naproxen Lofepramine An increased risk of bleeding Details Naproxen Lornoxicam Increased risk of bleeding Details Naproxen Loxoprofen Increased risk of bleeding Details Naproxen Lumiracoxib Increased risk of bleeding Details Naproxen Magnesium Salicylate Increased risk of bleeding Details Naproxen Meadowsweet Increased risk of bleeding Details Naproxen Melitracen An increased risk of bleeding Details Naproxen Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Milnacipran Savella An increased risk of bleeding Details Naproxen Morniflumate Increased risk of bleeding Details Naproxen Nadroparin An increased risk of bleeding Details Naproxen Nefazodone An increased risk of bleeding Details Naproxen Nepafenac Ilevro Increased risk of bleeding Details Naproxen Niflumic Acid Increased risk of bleeding Details Naproxen Nimesulide Increased risk of bleeding Details Naproxen Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Naproxen Nortriptyline An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.