Naproxen

309 interactions 807 cited references

Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen

About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab

4 Contraindicated 228 Major 66 Moderate 11 Minor

All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Major

Naproxen Olsalazine Dipentum Increased risk of bleeding Details Naproxen Opipramol An increased risk of bleeding Details Naproxen Oxaprozin Coxanto Increased risk of bleeding Details Naproxen Oxyphenbutazone Increased risk of bleeding Details Naproxen Parecoxib Increased risk of bleeding Details Naproxen Parnaparin An increased risk of bleeding Details Naproxen Paroxetine Paxil An increased risk of bleeding Details Naproxen Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Naproxen Pentosan Polysulfate Sodium An increased risk of bleeding Details Naproxen Pentoxifylline Pentoxil® An increased risk of bleeding Details Naproxen Phenindione An increased risk of bleeding Details Naproxen Phenprocoumon An increased risk of bleeding Details Naproxen Phenylbutazone Equi-Phar Increased risk of bleeding Details Naproxen Phenyl Salicylate Increased risk of bleeding Details Naproxen Piketoprofen Increased risk of bleeding Details Naproxen Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Piroxicam Feldene Increased risk of bleeding Details Naproxen Pixantrone Increased CYP1A2 substrate exposure Details Naproxen Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Naproxen Prasugrel Effient An increased risk of bleeding Details Naproxen Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Naproxen Probenecid Increased naproxen exposure Details Naproxen Proglumetacin Increased risk of bleeding Details Naproxen Propyphenazone Increased risk of bleeding Details Naproxen Proquazone Increased risk of bleeding Details Naproxen Protein C Ceprotin An increased risk of bleeding Details Naproxen Protriptyline An increased risk of bleeding Details Naproxen Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Reviparin An increased risk of bleeding Details Naproxen Rivaroxaban Xarelto An increased risk of bleeding Details Naproxen Rofecoxib Increased risk of bleeding Details Naproxen Salicylamide Increased risk of bleeding Details Naproxen Salicylic Acid Increased risk of bleeding Details Naproxen Salsalate Disalcid Increased risk of bleeding Details Naproxen Selexipag Uptravi An increased risk of bleeding Details Naproxen Sibutramine An increased risk of bleeding Details Naproxen Sodium Salicylate Increased risk of bleeding Details Naproxen Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.