Naproxen

309 interactions 807 cited references

Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen

About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab

4 Contraindicated 228 Major 66 Moderate 11 Minor

All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Major

Naproxen Sulfasalazine Azulfidine Increased risk of bleeding Details Naproxen Sulfinpyrazone An increased risk of bleeding Details Naproxen Sulindac Clinoril® Increased risk of bleeding Details Naproxen Sulodexide An increased risk of bleeding Details Naproxen Tacrolimus Astagraf Acute renal failure Details Naproxen Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Naproxen Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Naproxen Tenoxicam Increased risk of bleeding Details Naproxen Tianeptine An increased risk of bleeding Details Naproxen Tiaprofenic Acid Increased risk of bleeding Details Naproxen Ticagrelor Brilinta An increased risk of bleeding Details Naproxen Ticlopidine Ticlid® An increased risk of bleeding Details Naproxen Tinzaparin An increased risk of bleeding Details Naproxen Tirofiban An increased risk of bleeding Details Naproxen Tolfenamic Acid Increased risk of bleeding Details Naproxen Tolmetin Tolectin 600 Increased risk of bleeding Details Naproxen Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Trazodone Raldesy An increased risk of bleeding Details Naproxen Treprostinil Orenitram An increased risk of bleeding Details Naproxen Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Naproxen Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Trimipramine An increased risk of bleeding Details Naproxen Trolamine Salicylate Increased risk of bleeding Details Naproxen Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Naproxen Valdecoxib Increased risk of bleeding Details Naproxen Venlafaxine An increased risk of bleeding Details Naproxen Vilazodone Viibryd An increased risk of bleeding Details Naproxen Vorapaxar Zontivity An increased risk of bleeding Details Naproxen Vortioxetine Trintellix An increased risk of bleeding Details Naproxen Warfarin Coumadin An increased risk of bleeding Details Naproxen Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details Naproxen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Naproxen Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Atenolol Tenormin Reduced antihypertensive effect Details Naproxen Acebutolol Sectral® Reduced antihypertensive effect Details Naproxen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Betaxolol Betoptic S Reduced antihypertensive effect Details Naproxen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Naproxen Bisoprolol Zebeta® Reduced antihypertensive effect Details

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