Naproxen

309 interactions 807 cited references
Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen
About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab
4 Contraindicated 228 Major 66 Moderate 11 Minor
All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Moderate

Naproxen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Naproxen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Esmolol Brevibloc Reduced antihypertensive effect Details Naproxen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Labetalol Normodyne® Reduced antihypertensive effect Details Naproxen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Naproxen Levofloxacin Levaquin An increased risk of seizures Details Naproxen Levofloxacin Injection Levaquin An increased risk of seizures Details Naproxen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Nadolol Corgard Reduced antihypertensive effect Details Naproxen Amiodarone Nexterone Increased plasma levels of naproxen Details Naproxen Anisindione An increased risk of bleeding Details Naproxen Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Carteolol Reduced antihypertensive effect Details Naproxen Carvedilol Coreg Reduced antihypertensive effect Details Naproxen Celiprolol Reduced antihypertensive effect Details Naproxen Ciprofloxacin An increased risk of convulsions Details Naproxen Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Naproxen Dicumarol An increased risk of bleeding Details Naproxen Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Ethotoin Increased free hydantoin plasma concentrations Details Naproxen Fosphenytoin Cerebyx Increased free hydantoin plasma concentrations Details Naproxen Ginkgo An increased risk of bleeding Details Naproxen Levobunolol Betagan Reduced antihypertensive effect Details Naproxen L-Methylfolate Decreased l-methylfolate efficacy Details Naproxen Ma Huang Increased risk of developing gastric mucosal lesions Details Naproxen Mephenytoin Increased free hydantoin plasma concentrations Details Naproxen Metipranolol Reduced antihypertensive effect Details Naproxen Metoprolol Kapspargo Reduced antihypertensive effect Details Naproxen Nebivolol Bystolic Reduced antihypertensive effect Details Naproxen Norfloxacin An increased risk of seizures Details Naproxen Ofloxacin Floxin® An increased risk of seizures Details Naproxen Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Oxprenolol Reduced antihypertensive effect Details Naproxen Penbutolol Levatol® Reduced antihypertensive effect Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.