Naproxen

309 interactions 807 cited references
Also sold as: Aleve Aleve® Anaprox Anaprox® Anaprox® DS EC-Naprosyn® Flanax® Naprelan Naprelan® Naprosyn Naprosyn® Wal-Proxen
About Naproxen

Naproxen is an NSAID pain reliever used to reduce pain, swelling, and stiffness from arthritis and other conditions. Read the full Naproxen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Abciximab
4 Contraindicated 228 Major 66 Moderate 11 Minor
All (309) Contraindicated (4) Major (228) Moderate (66) Minor (11)

Moderate

Naproxen Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Phenytoin Dilantin Increased free hydantoin plasma concentrations Details Naproxen Pindolol Visken® Reduced antihypertensive effect Details Naproxen Pralatrexate Increased pralatrexate exposure Details Naproxen Propranolol Hemangeol Reduced antihypertensive effect Details Naproxen Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Sotalol Betapace Reduced antihypertensive effect Details Naproxen Sparsentan Filspari An increased risk of worsening of renal function Details Naproxen Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Sucralfate Carafate Delayed absorption of naproxen Details Naproxen Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Timolol Betimol Reduced antihypertensive effect Details Naproxen Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Naproxen Voriconazole Vfend Increased naproxen exposure and plasma concentration Details Naproxen Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Naproxen Ofloxacin Otic Floxin® Otic An increased risk of seizures Details

Minor

Naproxen Cholestyramine Resin Locholest® Delayed absorption of naproxen Details Naproxen Aluminum Carbonate, Basic Delayed absorption of naproxen Details Naproxen Aluminum Hydroxide AlternaGEL® Delayed absorption of naproxen Details Naproxen Aluminum Phosphate Delayed absorption of naproxen Details Naproxen Cholestyramine Prevalite Delayed absorption of naproxen Details Naproxen Dihydroxyaluminum Aminoacetate Delayed absorption of naproxen Details Naproxen Dihydroxyaluminum Sodium Carbonate Delayed absorption of naproxen Details Naproxen Magaldrate Delayed absorption of naproxen Details Naproxen Magnesium Carbonate Delayed absorption of naproxen Details Naproxen Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Delayed absorption of naproxen Details Naproxen Magnesium Trisilicate Delayed absorption of naproxen Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.