Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

S
Somatropin 4 Sonidegib 12 Sonrotoclax 8 Sorafenib 75 Sorbitol 1 Sotagliflozin 25 Sotalol 124 Sotorasib 62 Sparfloxacin 92 Sparsentan 87 Sparteine 1 Spectinomycin 3 Spiramycin 17 Spirapril 39 Spironolactone 71 Squill 1 St John's Wort 156 Stanozolol 3 Stavudine 5 Stiripentol 13 Stramonium 10 Streptokinase 21 Streptomycin 19 Strontium Ranelate 15 Succinylcholine 19 Sucralfate 18 Sucroferric Oxyhydroxide 6 Sufentanil 56 Sugammadex 7 Sulbenicillin 1 Sulfacetamide 8 Sulfacytine 3 Sulfadiazine 13 Sulfadoxine 7 Sulfaguanidine 7 Sulfamerazine 7 Sulfamethazine 7 Sulfamethizole 12 Sulfamethoxazole 26 Sulfanilamide 6 Sulfaphenazole 8 Sulfapyridine 9 Sulfasalazine 47 Sulfathiazole 6 Sulfinpyrazone 69 Sulfisoxazole 9 Sulindac 94 Sulodexide 42 Sulopenem 5 Sulpiride 82 Sultamicillin 24 Sultopride 44 Sumatriptan 22 Sunitinib 87 Sunvozertinib 16 Suprofen 1 Suvorexant 40 Suzetrigine 57
T
Tacrine 8 Tacrolimus 157 Tadalafil 13 Tafamidis 4 Tafenoquine 3 Tafluprost 1 Talazoparib 14 Taletrectinib 80 Talinolol 9 Tamarind 4 Tamoxifen 89 Tamsulosin 21 Tan-Shen 22 Tapentadol 45 Tasimelteon 1 Tasonermin 4 Taurursodiol 31 Tazemetostat 110 Tazobactam 17 Tea 1 Tebipenem Pivoxil 2 Tecovirimat 12 Tedisamil 19 Tedizolid Phosphate 25 Teduglutide 4 Tegafur 47 Teicoplanin 11 Telaprevir 142 Telavancin 55 Telbivudine 1 Telisotuzumab Vedotin-Tllv 1 Telithromycin 146 Telmisartan 53 Telotristat Ethyl 31 Temazepam 27 Temocapril 2 Temocillin 15 Temsirolimus 20 Tenapanor 1 Tenecteplase 23 Tenofovir 1 Tenofovir Alafenamide 67 Tenofovir Disoproxil Fumarate 31 Tenoxicam 96 Tepotinib 13 Terazosin 16 Terbinafine 22 Terbutaline 12 Terbutaline Sulfate 1 Terfenadine 69 Teriflunomide 31 Teriparatide 1 Terodiline 10 Tertatolol 9 Testosterone 51 Testosterone Cypionate 1 Testosterone Enanthate 1 Testosterone Undecanoate 1 Tetanus Toxoid 12 Tetrabenazine 58 Tetracycline 27 Tetrahydrozoline 2