Medication interaction hub

What Supplements Interact with Levonorgestrel, Ethinyl Estradiol?

Levonorgestrel, Ethinyl Estradiol brand names: Nordette, Logynon ED, Microgynon 30, Ovranette, Trinordiol, and others. Every interaction below applies to the brands too.

241 Interactions 6 Major 197 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Levonorgestrel, Ethinyl Estradiol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Levonorgestrel, Ethinyl Estradiol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

241 supplements and herbal ingredients have interactions with Levonorgestrel, Ethinyl Estradiol on file in the HelloPharmacist interaction database — 6 rated major, 197 moderate, and 38 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Levonorgestrel, Ethinyl Estradiol.

Major 6 Moderate 197 Minor 38 No known interaction 1,211

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Levonorgestrel, Ethinyl Estradiol: Top Interactions at a Glance

The Levonorgestrel, Ethinyl Estradiol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 241 interacting ingredients — plus 1,211 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Levonorgestrel, Ethinyl Estradiol Combinations Today

The Levonorgestrel, Ethinyl Estradiol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Copper + Levonorgestrel, Ethinyl Estradioli

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Minor Likelihood Possible Selenium + Levonorgestrel, Ethinyl Estradioli

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Possible Eleuthero + Levonorgestrel, Ethinyl Estradioli

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Probable Black Tea + Levonorgestrel, Ethinyl Estradioli

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Echinacea + Levonorgestrel, Ethinyl Estradioli

Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Read the full interaction Moderate Likelihood Probable Coffee + Levonorgestrel, Ethinyl Estradioli

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction
The complete list

Every Supplement Checked Against Levonorgestrel, Ethinyl Estradiol

All 1,452 ingredients in our database, ranked by severity — 241 with a Levonorgestrel, Ethinyl Estradiol interaction on file and 1,211 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Levonorgestrel, Ethinyl Estradiol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Copper with Levonorgestrel, Ethinyl Estradiol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Levonorgestrel, Ethinyl Estradiol answer

Can you take Selenium with Levonorgestrel, Ethinyl Estradiol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + Levonorgestrel, Ethinyl Estradiol answer

Can you take Eleuthero with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Full Eleuthero + Levonorgestrel, Ethinyl Estradiol answer

Can you take Black Tea with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Black Tea + Levonorgestrel, Ethinyl Estradiol answer

Can you take Echinacea with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Full Echinacea + Levonorgestrel, Ethinyl Estradiol answer

Can you take Saw Palmetto with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Saw palmetto might reduce the effectiveness of estrogens.

Full Saw Palmetto + Levonorgestrel, Ethinyl Estradiol answer

Can you take Schizonepeta with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Levonorgestrel, Ethinyl Estradiol answer

Can you take Senna with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking senna may interfere with the absorption of exogenous estrogens.

Full Senna + Levonorgestrel, Ethinyl Estradiol answer

Can you take Slippery Elm with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Levonorgestrel, Ethinyl Estradiol answer

Can you take Soy with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, soy might competitively inhibit the effects of estrogen replacement therapy.

Full Soy + Levonorgestrel, Ethinyl Estradiol answer

Can you take Spearmint with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Levonorgestrel, Ethinyl Estradiol answer

Can you take Strawberry with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Levonorgestrel, Ethinyl Estradiol answer

Can you take Strontium with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.

Full Strontium + Levonorgestrel, Ethinyl Estradiol answer

Can you take Sulforaphane with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.

Full Sulforaphane + Levonorgestrel, Ethinyl Estradiol answer

Can you take Sweet Annie with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Levonorgestrel, Ethinyl Estradiol answer

Can you take Sweet Clover with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Levonorgestrel, Ethinyl Estradiol answer

Can you take Sweet Orange with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Levonorgestrel, Ethinyl Estradiol answer

Can you take Syrian Rue with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Levonorgestrel, Ethinyl Estradiol answer

Can you take Terminalia with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Levonorgestrel, Ethinyl Estradiol answer

Can you take Testolone with Levonorgestrel, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Levonorgestrel, Ethinyl Estradiol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Levonorgestrel, Ethinyl Estradiol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Levonorgestrel, Ethinyl Estradiol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Levonorgestrel, Ethinyl Estradiol sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Levonorgestrel, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Levonorgestrel, Ethinyl Estradiol through this category.

Related: does Levonorgestrel, Ethinyl Estradiol deplete any nutrients?

Levonorgestrel, Ethinyl Estradiol has 49 reported nutrient associations in the research literature — see the Levonorgestrel, Ethinyl Estradiol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Levonorgestrel, Ethinyl Estradiol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Levonorgestrel, Ethinyl Estradiol.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Levonorgestrel, Ethinyl Estradiol & Supplements: Common Questions

What supplements interact with Levonorgestrel, Ethinyl Estradiol?
More than you might expect — 241 in total, though they are far from equal: 6 are rated major, 197 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Levonorgestrel, Ethinyl Estradiol supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Levonorgestrel, Ethinyl Estradiol?
Usually yes — most people on Levonorgestrel, Ethinyl Estradiol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Nordette have the same supplement interactions as Levonorgestrel, Ethinyl Estradiol?
Yes — Nordette, Logynon ED, Microgynon 30, Ovranette, Trinordiol and other brands all contain Levonorgestrel, Ethinyl Estradiol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Levonorgestrel, Ethinyl Estradiol deplete any vitamins or nutrients?
It might — Levonorgestrel, Ethinyl Estradiol has 49 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Levonorgestrel, Ethinyl Estradiol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Levonorgestrel, Ethinyl Estradiol and my other medications?
This page covers Levonorgestrel, Ethinyl Estradiol against supplements and herbal ingredients. Checking Levonorgestrel, Ethinyl Estradiol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.