Medication interaction hub

What Supplements Interact with Tenecteplase?

Tenecteplase brand name: TNKase. Every interaction below applies to the brands too.

203 Interactions 2 Major 184 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tenecteplase? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tenecteplase against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tenecteplase (TNKase) is a clot-busting drug given in the emergency room for strokes and heart attacks, so the real question is not what you would take alongside it but what is already in your system when the injection arrives. This list deserves genuine caution. Of the 203 ingredients on file, 202 act on blood clotting, nearly all by pushing bleeding risk higher, and bleeding is already this drug's most feared complication. Danshen and piracetam, the two rated major, both have documented antiplatelet effects.

The 184 moderate entries repeat that same bleeding theme, mostly from lab and animal research, and 17 more rate minor; a small cluster of four may also interfere with how clot-dissolving drugs themselves work. No one schedules a stroke, so the useful step is making sure the hospital team, or the family member speaking for you, knows every supplement you take regularly. Danshen, common in traditional Chinese formulas, is the one to name first.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 184 Minor 17 No known interaction 1,249

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tenecteplase: Top Interactions at a Glance

The Tenecteplase supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 203 interacting ingredients — plus 1,249 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tenecteplase Combinations Today

The Tenecteplase + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Oregon Grape + Tenecteplasei

Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Clove + Tenecteplasei

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Major Likelihood Probable Danshen + Tenecteplasei

Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Tenecteplasei

Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Potato + Tenecteplasei

Theoretically, concomitant use of potato may enhance the effects of thrombolytic drugs.

Read the full interaction Moderate Likelihood Possible Bilberry + Tenecteplasei

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Tenecteplase

All 1,452 ingredients in our database, ranked by severity — 203 with a Tenecteplase interaction on file and 1,249 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tenecteplase?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Oregon Grape with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregon Grape + Tenecteplase answer

Can you take Clove with Tenecteplase?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Clove + Tenecteplase answer

Can you take Danshen with Tenecteplase?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Tenecteplase answer

Can you take Dimethylsulfoxide (dmso) with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Dimethylsulfoxide (dmso) + Tenecteplase answer

Can you take Potato with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potato may enhance the effects of thrombolytic drugs.

Full Potato + Tenecteplase answer

Can you take Burdock with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Burdock + Tenecteplase answer

Can you take Caffeine with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Caffeine + Tenecteplase answer

Can you take Canadian Fleabane with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Full Canadian Fleabane + Tenecteplase answer

Can you take Cannabis with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Cannabis + Tenecteplase answer

Can you take Capsicum with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Tenecteplase answer

Can you take Carrageenan with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Full Carrageenan + Tenecteplase answer

Can you take Cat's Claw with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cat's Claw + Tenecteplase answer

Can you take Celery with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Celery + Tenecteplase answer

Can you take Ceylon Leadwort with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the ri...

Full Ceylon Leadwort + Tenecteplase answer

Can you take Chaga with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Chaga + Tenecteplase answer

Can you take Chanca Piedra with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Chanca Piedra + Tenecteplase answer

Can you take Chokeberry with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Chokeberry + Tenecteplase answer

Can you take Chrysin with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Chrysin + Tenecteplase answer

Can you take Cilantro with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that extracts of cilantro can inhibit platelet aggregation.

Full Cilantro + Tenecteplase answer

Can you take Cinchona with Tenecteplase?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might increase the drug effects and risk of bleeding with anticoagulant and antiplatelet drugs.

Full Cinchona + Tenecteplase answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tenecteplase is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tenecteplase, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tenecteplase sits in 2 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Tenecteplase through this category.

Thrombolytic Drugs 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Tenecteplase through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tenecteplase

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tenecteplase.

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Pharmacist Counseling Corner

Tenecteplase & Supplements: Common Questions

What supplements interact with Tenecteplase?
More than you might expect — 203 in total, though they are far from equal: 2 are rated major, 184 moderate, and 17 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Danshen, Piracetam, Bridelia.
Which Tenecteplase supplement interactions are the most serious?
Focus on the major group: Danshen and Piracetam. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tenecteplase?
Usually yes — most people on Tenecteplase can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like TNKase have the same supplement interactions as Tenecteplase?
Yes — TNKase all contain Tenecteplase, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tenecteplase and my other medications?
This page covers Tenecteplase against supplements and herbal ingredients. Checking Tenecteplase against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.