Alprazolam
44 interactions 5 explained in plain English
Also sold as:
Xanax
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketoconazole Topical
Acetaminophen And Codeine
Mercaptopurine
Diphenhydramine Injection
Digoxin
Azathioprine
Major
Alprazolam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Alprazolam Abametapir Explained Increased exposure of CYP3A4 substrate Details Alprazolam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Alprazolam Aripiprazole Injection Abilify Increased risk of CNS depression Details Alprazolam Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Alprazolam Azathioprine Azasan An increased risk of hepatotoxicity Details Alprazolam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Alprazolam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Alprazolam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Alprazolam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Alprazolam Cyclosporine Injection Atopica Increased ALPRAZolam exposure and an increased risk of ALPRAZolam-related adverse reactions Details Alprazolam Cyclosporine Ophthalmic Cequa Increased ALPRAZolam exposure and an increased risk of ALPRAZolam-related adverse reactions Details Alprazolam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Alprazolam Diazepam Rectal Diastat Increased risk of CNS depression Details Alprazolam Digoxin Cardoxin® Increased digoxin exposure Details Alprazolam Diphenhydramine Injection Banophen Increased risk of CNS depression Details Alprazolam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Alprazolam Esketamine Nasal Spray Spravato Increased risk of sedation Details Alprazolam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Alprazolam Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Alprazolam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Alprazolam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Alprazolam Lacosamide Injection Motpoly An increased risk of CNS depression Details Alprazolam Letermovir Injection Prevymis Increased ALPRAZolam exposure and an increased risk of ALPRAZolam-related adverse reactions Details Alprazolam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Alprazolam Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Alprazolam Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Alprazolam Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Alprazolam Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Alprazolam Methylergonovine Methergine Increased methylergonovine exposure Details Alprazolam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Alprazolam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Alprazolam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Alprazolam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Alprazolam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Alprazolam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Alprazolam Nifedipine Adalat® Increased NIFEdipine exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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