Alprazolam

Name: Alprazolam Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

44 interactions 5 explained in plain English

Also sold as: Xanax

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Acetaminophen And Codeine Mercaptopurine Diphenhydramine Injection Digoxin Azathioprine

1 Contraindicated 37 Major 6 Moderate

All (44) Contraindicated (1) Major (37) Moderate (6)

Moderate

Alprazolam Omeprazole Gastrobim Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Alprazolam Sertraline Explained An increased risk of psychomotor impairment and sedation Details Alprazolam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Alprazolam Dofetilide Tikosyn Increased dofetilide exposure Details Alprazolam Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Alprazolam Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.