Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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Pegloticase Injection 4 Pegvisomant 4 Pembrolizumab Injection 15 Pemetrexed 25 Pemetrexed Injection 80 Pemigatinib 7 Penbutolol 190 Penfluridol 2 Penicillamine 2 Penicillin G 22 Penicillin G Benzathine 5 Penicillin G Benzathine Injection 14 Penicillin G Procaine 16 Penicillin G Procaine Injection 39 Penicillin V 21 Penicillin V Potassium 50 Pentaerythritol Tetranitrate 1 Pentamidine 56 Pentazocine 41 Pentobarbital 31 Pentobarbital Sodium 2 Pentopril 6 Pentosan Polysulfate Sodium 36 Pentostatin 4 Pentostatin Injection 22 Pentoxifylline 33 Peppermint 7 Perampanel 28 Perazine 20 Pergolide 2 Periciazine 29 Perindopril 195 Perphenazine 71 Pertussis Vaccine 2 Pertuzumab 4 Pexidartinib 59 Pheasant's Eye 1 Phendimetrazine 1 Phenelzine 54 Phenindamine 1 Phenindione 68 Pheniramine 1 Phenmetrazine 1 Phenobarbital 219 Phenobarbital Sodium 2 Phenoxybenzamine 16 Phenprocoumon 97 Phentermine 1 Phentolamine 16 Phenyl Salicylate 16 Phenylalanine 2 Phenylbutazone 102 Phenylephrine 6 Phenylephrine Hydrochloride 1 Phenylpropanolamine 7 Phenyltoloxamine 1 Phenytoin 237 Phenytoin Sodium 2 Phenytoin Sodium, Extended 2 Physostigmine 1 Pibrentasvir 45 Piketoprofen 91 Pilocarpine 2 Pimavanserin 71 Pimozide 155 Pinaverium 1 Pinazepam 7 Pindolol 58 Pioglitazone 60 Pipamperone 42 Pipecuronium 16 Pipemidic Acid 1 Pipenzolate Bromide 10 Piperacetazine 19 Piperacillin 27 Piperaquine 91 Piperazine 2 Piperine 14 Pipotiazine 27 Piracetam 17 Pirarubicin 1 Pirenzepine 11 Piretanide 50 Pirfenidone 4 Piritramide 29 Pirmenol 13 Piroxicam 97 Pirprofen 2 Pirtobrutinib 50 Pitavastatin 19 Pitolisant 97 Pivampicillin 15 Pivekimab Sunirine 5 Pivmecillinam 8 Pixantrone 23 Pizotyline 1 Plazomicin 5 Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate 4 Pneumococcal Vaccine 11 Pneumococcal Vaccine Polyvalent 11 Pneumococcal Vaccine, Diphtheria Conjugate 11 Poliovirus Vaccine, Inactivated 2 Poliovirus Vaccine, Live 39 Polyestradiol Phosphate 3 Polyethylene Glycol 3350 2 Polygeline 3 Polystyrene Sulfonate 1 Polythiazide 64 Pomalidomide 3 Ponatinib 10 Ponesimod 81 Porfimer 22 Posaconazole 166 Potassium 11 Potassium Chloride 10 Potassium Citrate 45 Potassium Iodide 1 Potassium Oxybate 25 Potassium Phosphate 15 Potassium Phosphate, Dibasic 1