Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

P
Potassium Phosphate, Monobasic 1 Practolol 24 Prajmaline 14 Pralatrexate 23 Pralsetinib 8 Pramipexole 2 Pramlintide 59 Pranoprofen 56 Prasterone 1 Prasugrel 49 Pravastatin 17 Prazepam 22 Praziquantel 6 Prazosin 16 Prednicarbate 6 Prednisolone 53 Prednisone 68 Pregabalin 31 Pretomanid 8 Prilocaine 4 Primaquine 2 Primidone 204 Pristinamycin 4 Probenecid 59 Probucol 52 Procainamide 59 Procaine 1 Procarbazine 44 Prochlorperazine 83 Procyclidine 12 Progesterone 2 Proglumetacin 91 Proguanil 7 Promazine 27 Promestriene 3 Promethazine 96 Propafenone 67 Propantheline 13 Propatyl Nitrate 4 Propicillin 6 Propiomazine 7 Propionic Acid 19 Propiverine 11 Propizepine 1 Propofol 30 Propoxyphene 6 Propranolol 76 Propylhexedrine 3 Propylthiouracil 4 Propyphenazone 91 Proquazone 91 Proscillaridin 1 Protein C 46 Protriptyline 106 Prulifloxacin 12 Pseudoephedrine 6 Pseudoephedrine Hydrochloride 1 Psyllium 8 Pyrazinamide 2 Pyridostigmine 2 Pyridoxine 1 Pyrilamine 1 Pyrimethamine 7
Q
Quazepam 22 Quercetin 22 Quetiapine 98 Quinacillin 5 Quinapril 62 Quinestrol 5 Quinethazone 46 Quinidine 91 Quinine 79 Quinupristin 20 Quizartinib 73
R
Rabeprazole 28 Rabies Vaccine 35 Radium Ra 223 Dichloride 1 Raloxifene 2 Raltegravir 14 Ramelteon 23 Ramipril 64 Ranitidine 45 Ranitidine Bismuth Citrate 9 Ranolazine 149 Rapacuronium 17 Rasagiline 50 Ravulizumab-Cwvz 1 Reboxetine 4 Red Clover 15 Red Yeast Rice 2 Regadenoson 1 Regorafenib 6 Relacorilant 139 Relugolix 340 Remdesivir 3 Remibrutinib 35 Remifentanil 37 Remimazolam 21 Remoxipride 21 Repaglinide 65 Repotrectinib 70 Reserpine 3 Resmetirom 10 Resveratrol 7 Retapamulin 1 Reteplase, Recombinant 20 Revefenacin 18 Reviparin 49 Revumenib 60 Ribavirin 7 Ribociclib 140 Rifabutin 65 Rifampin 176 Rifapentine 92 Rifaximin 6 Rilonacept 7 Rilpivirine 73 Riluzole 6 Rilzabrutinib 123 Rimegepant 15