Prednisone

68 interactions 4 explained in plain English
Also sold as: Deltasone Rayos
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Prednisone Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Prednisone Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Prednisone Aldesleukin Proleukin Reduced antitumor effectiveness Details Prednisone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Prednisone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Prednisone Atogepant Qulipta Reduced atogepant exposure Details Prednisone Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Prednisone Amlodipine Amvaz® Reduced amLODIPine exposure Details Prednisone Asparaginase Erwinia Chrysanthemi Injection Erwinaze An increased risk of bleeding Details Prednisone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Prednisone Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Prednisone Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Prednisone Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Prednisone Etodolac Lodine Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Fenoprofen Fenopron Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Prednisone Flurbiprofen Ansaid Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Prednisone Gemifloxacin Factive An increased risk of tendon rupture Details Prednisone Ibuprofen Addaprin Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Ketoprofen Actron® Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Ketorolac Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Ketorolac Injection Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Ketorolac Nasal Spray Sprix Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Ketorolac Ophthalmic Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Levofloxacin Levaquin An increased risk of tendon rupture Details Prednisone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Prednisone Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Prednisone Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Prednisone Lumateperone Caplyta Reduced lumateperone exposure Details Prednisone Meclofenamate Meclodium® Increased risk of gastrointestinal ulcer or bleeding Details Prednisone Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Prednisone Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details

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