Herb & supplement monograph

Lychee Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Lychee interacts with medications. The heart of this page is the interaction list — every drug Lychee is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lychee is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Lychee against your medication

Add one medication
Lychee
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page

Lychee Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Lychee drug interaction appears low for most people. None of the listed interactions are rated major, most are minor, and even the moderate ones rest on animal or lab research rather than solid human studies.

Interactions deserving the most attention

The main combination worth watching is with diabetes medications. Animal research suggests lychee seed extract can lower blood sugar, and some research in children has linked lychee to low blood sugar, so adding lychee could in theory push blood sugar lower than intended in people whose levels are closely managed. There is also a lab-based suggestion that lychee could slightly dampen the effect of immunosuppressants, but this has never been seen in people and is rated minor.

What the rest of the list means

Although lychee appears alongside a long list of medications, that does not mean each pairing is harmful. Nearly all of these entries are theoretical, extended from how lychee might behave based on animal or test-tube findings. None have been confirmed as clinically meaningful problems in human studies so far.

Check your medications against Lychee

Based on HelloPharmacist’s Lychee interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Lychee

207 medications have a known interaction with Lychee, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Acetohexamide interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Albiglutide interaction
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Alogliptin, Pioglitazone interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
CanagliflozinInvokana
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effects
Canagliflozin, MetforminInvokamet
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Canagliflozin, Metformin interaction
Canagliflozin, Metformin HydrochlorideInvokamet XR
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Canagliflozin, Metformin Hydrochloride interaction
ChlorpropamideChlorpropam, Diabinese
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Chlorpropamide interaction
DapagliflozinFarxiga
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effects
Dapagliflozin Propanediol, MetforminXigduo XR
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dapagliflozin Propanediol, Metformin interaction
Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interaction
Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interaction
Dasiglucagon HydrochlorideZegalogue
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effects
DulaglutideTrulicity
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effects
EmpagliflozinJardiance
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effects
Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Empagliflozin, Linagliptin, Metformin Hydrochloride interaction
Empagliflozin, MetforminSynjardy
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Empagliflozin, Metformin interaction
Empagliflozin, Metformin HydrochlorideSynjardy XR
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Empagliflozin, Metformin Hydrochloride interaction
ErtugliflozinSteglatro
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effects
Ertugliflozin, Metformin HydrochlorideSegluromet
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Ertugliflozin, Metformin Hydrochloride interaction
ExenatideBydureon, Byetta
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Exenatide interaction Exenatide drug page: uses, dosage & side effects
Exenatide SyntheticBydureon BCISE
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effects
GliclazideDiamicron
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Gliclazide interaction
GlimepirideAmaryl
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Glimepiride interaction Glimepiride drug page: uses, dosage & side effects
GlipizideGlucotrol, Glucotrol XL
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Glipizide interaction Glipizide drug page: uses, dosage & side effects
Glipizide, MetforminMetaglip
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Glipizide, Metformin interaction
GlucagonBaqsimi, Glucagon
Moderate Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full Lychee + Glucagon interaction Glucagon drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Lychee combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Lychee affects

Every type of medication (drug category) Lychee is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Lychee interacts with
Antidiabetes DrugsImmunosuppressants
Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lychee seed reduces fasting and 2-hour postprandial blood glucose and improves impaired glucose tolerance in rats with type 2 diabetes. Additionally, retrospective research in children has found an association between lychee consumption and increased odds of acute hypoglycemic encephalopathy.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.
In vitro, flavonoids extracted from lychee show immunostimulant effects. So far, this effect has not been reported in humans.

Likelihood Possible Evidence D
Monograph

Lychee: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds. While the fruit is a healthy food for most people, supplement-strength extracts have only limited research behind specific health claims, and eating large amounts of unripe lychee on an empty stomach has been linked to dangerous low blood sugar in undernourished children. Talk to your pharmacist or doctor before using lychee extracts for any health condition.

Scientific name
Litchi chinensis
Family
Sapindaceae
Part used
Fruit (pulp), seed, and peel; sometimes flowers and leaves
Common forms
Fresh or dried fruit, juice, extract capsules, seed powder, teas
People commonly use it for
  • General nutrition and antioxidant support
  • Digestive complaints (traditional use)
  • Cough and sore throat (traditional use)
  • Blood sugar support (preliminary)
  • Weight and metabolic support (preliminary)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

The fruit is generally safe as food, but concentrated extracts are not well studied and unripe fruit carries specific risks.

PregnancyInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Lychee (Litchi chinensis) is a small, sweet, juicy tropical fruit with a rough red or pink skin and a single large seed. It comes from an evergreen tree in the soapberry family and is native to southern China and Southeast Asia. Today it is also grown in India, parts of Africa, Australia, and other warm regions.

People mostly enjoy lychee as a fresh or canned fruit, juice, or dried snack. In traditional medicine systems, different parts of the plant — including the fruit, seed, and peel — have been used for digestion, coughs, and other complaints. More recently, lychee fruit and peel extracts have been sold as supplements that are promoted for antioxidant and metabolic support.

Uses & effectiveness

As a food, lychee is a good source of vitamin C and natural plant antioxidants, and it can be part of a healthy diet. This is its best-supported and most common use.

For supplement uses, the evidence is much weaker. Some early laboratory and animal studies suggest lychee compounds may have antioxidant and anti-inflammatory effects, and a few small human studies have looked at lychee extracts for blood sugar, body weight, or exercise recovery. These studies are preliminary, small, or low quality, so we cannot say lychee extracts are proven to treat or prevent any health condition.

In short: lychee is a healthy fruit, but the science does not yet support taking lychee supplements for specific medical problems.

How it works

Lychee contains vitamin C and a variety of plant compounds called polyphenols, including flavonoids and proanthocyanidins (especially in the peel and seed). In the lab, these compounds can act as antioxidants, meaning they help neutralize unstable molecules called free radicals.

Researchers have proposed that these antioxidant and anti-inflammatory effects might help with things like blood sugar control and metabolism. However, most of this work has been done in test tubes or animals, and what happens in a lab dish does not always translate to real benefits in people.

Unripe lychee also contains natural substances (such as hypoglycin A and a related compound) that can lower blood sugar. While this is part of the antioxidant story, these same compounds explain some of the safety concerns below.

Safety & precautions

Ripe lychee fruit eaten in normal amounts is generally safe for most people. The main known danger involves eating large amounts of unripe lychee on an empty stomach, especially in malnourished children. This has been linked to outbreaks of severe, sometimes fatal, low blood sugar (hypoglycemia) and brain swelling in certain regions. Eating ripe fruit in moderation, and not skipping meals, lowers this risk.

People with diabetes or those taking blood-sugar-lowering medicine should be cautious, since lychee may affect blood sugar. Anyone with a known allergy to lychee or related fruits should avoid it.

Pregnancy and breastfeeding: Eating lychee fruit in normal food amounts is likely fine. However, concentrated lychee extracts and supplements have not been studied in pregnant or breastfeeding people, so it is safest to avoid them and stick to the fruit. When in doubt, ask your doctor or pharmacist.

Side effects

Lychee fruit is usually well tolerated. Some people may have an allergic reaction, with itching, hives, swelling, or in rare cases trouble breathing — seek medical help right away if this happens.

Eating a lot of lychee, particularly unripe fruit or on an empty stomach, can cause low blood sugar, which may lead to dizziness, sweating, confusion, or fainting. Because lychee is high in natural sugar, eating large amounts may also raise blood sugar in people with diabetes and add extra calories.

There is little safety information on long-term use of concentrated lychee extracts, so side effects from supplements are not well known.

Lychee: Reported Adverse Effects

Documented safety reports on Lychee from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Dermatitis Immunologic

Orally, lychee can cause allergic reactions such as urticaria, dermatitis, tongue and lip swelling, shortness of breath, and anaphylaxis.

Topically, contact with lychee fruit can cause allergic contact dermatitis.

  1. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol 2002;13(1):64-7.
  2. Giannattasio M, Serafini M, Guarrera P, et al. Contact urticaria from litchi fruit (Litchi chinensis Sonn.). Contact Dermatitis 1995;33(1):67.
  3. Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol 2007;17(3):199-201.
  4. Valsecchi R, Leghissa P. Contact allergy due to lychee. Acta Derm Venereol. 2013;93(1):90-1.
Epilepsy Neurologic/CNS

Orally, lychee has been linked to hypoglycemic encephalopathy. A 20-year retrospective review of cases from India, Vietnam, and Bangladesh found an association between lychee consumption and increased risk of acute hypoglycemic encephalopathy in children, especially in those who were malnourished. They presented with seizures and other neurological symptoms and had a high mortality rate. The association has been questioned, but is supported by the presence in the children's urine of hypoglycin A (MCPA) and methylenecyclopropylglycine (MCPG), constituents of unripe lychee fruit, which can cause hypoglycemic encephalopathy in animal models.

  1. John TJ, Das M. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Point. Indian Pediatr. 2016;53(5):399.
  2. John TJ. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Pediatric Infectious Disease Specialist's Viewpoint. Indian Pediatr. 2017;54(4):323-325.
  3. Shrivastava A, Kumar A, Thomas JD, et al. Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study. Lancet Glob Health. 2017;5(4):e458-e466.
  4. Spencer PS, Palmer VS, Mazumder R. Probable toxic cause for suspected lychee-linked viral encephalitis. Emerg Infect Dis. 2015;21(5):904-5.
  5. Mathew JL. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Evidence-based Medicine Viewpoint. Indian Pediatr. 2017;54(4):319-323.
  6. Vashishtha VM. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint. Indian Pediatr. 2016 May 8;53(5):399-402.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established standard dose for lychee supplements or extracts. The fruit itself can be eaten as a normal part of the diet in moderation.

If you use a lychee extract or capsule product, follow the directions on the product label, and do not exceed the recommended amount. Because supplement strengths vary and are not standardized, it is a good idea to check with your pharmacist or doctor before starting, especially if you have diabetes, are pregnant or breastfeeding, or take other medicines.

Pregnancy & Breastfeeding

Lychee & Pregnancy

Insufficient reliable information

Insufficient reliable information is available; avoid using.

Lychee & Breastfeeding

Insufficient reliable information

Insufficient reliable information is available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 12 references that drive our Lychee monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol 2002;13(1):64-7. PubMed
  2. Giannattasio M, Serafini M, Guarrera P, et al. Contact urticaria from litchi fruit (Litchi chinensis Sonn.). Contact Dermatitis 1995;33(1):67.
  3. Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol 2007;17(3):199-201.
  4. Guo JW. Effects of Litchi seed on enhancing insulin sensitivity in type 2 diabetic-insulin resistant rats. Chinese J New Drugs 2003;12:526-9.
  5. Zhao M, Yang B, Wang J, et al. Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. Int Immunopharmacol 2007;7(2):162-6. PubMed
  6. John TJ, Das M. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Point. Indian Pediatr. 2016;53(5):399.
  7. John TJ. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Pediatric Infectious Disease Specialist's Viewpoint. Indian Pediatr. 2017;54(4):323-325. DOI
  8. Mathew JL. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Evidence-based Medicine Viewpoint. Indian Pediatr. 2017;54(4):319-323. PubMed
  9. Shrivastava A, Kumar A, Thomas JD, et al. Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study. Lancet Glob Health. 2017;5(4):e458-e466.
  10. Spencer PS, Palmer VS, Mazumder R. Probable toxic cause for suspected lychee-linked viral encephalitis. Emerg Infect Dis. 2015;21(5):904-5. DOI
  11. Valsecchi R, Leghissa P. Contact allergy due to lychee. Acta Derm Venereol. 2013;93(1):90-1. PubMed
  12. Vashishtha VM. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint. Indian Pediatr. 2016 May 8;53(5):399-402.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Lychee

49 brands in our database make a supplement containing Lychee.

Product directory

Supplement products with Lychee

106 products in our database contain Lychee. Open any to see its full ingredient list and every drug interaction we check.

10-Day Acai Berry Easy-Cleanse by Applied Nutrition Tablet Or Pill 40 Tablet(s) View ingredients & interactions 14-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 56 Tablet(s) View ingredients & interactions 14-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 56 Tablet(s) View ingredients & interactions 5-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 20 Tablet(s) View ingredients & interactions Acai Berry Metabolism Boost by NewtonEverett Capsule 120 Capsule(s) View ingredients & interactions Acai Berry Metabolism Boost by NewtonEverett Capsule 120 Capsule(s) View ingredients & interactions Acai Berry Slim Down by NewtonEverett Tablet Or Pill 56 Tablet(s) View ingredients & interactions Acai Berry Slim Down by NewtonEverett Tablet Or Pill 56 Tablet(s) View ingredients & interactions Acai Power Berry Pure-Body Cleanse by Nature's Secret Tablet Or Pill 56 Tablet(s) View ingredients & interactions AdipoLean II by Pure Encapsulations Capsule 90 Capsule(s) View ingredients & interactions Advanced Cortisol Balance by Life Extension Capsule 30 Vegetarian Capsule(s) View ingredients & interactions Amplified Creatine XXX Ripped Orange Twist by GNC Pro Performance AMP Powder 13.54 Oz(s) · 383.8 Gram(s) View ingredients & interactions Complete Neurovascular Support by Whitaker Nutrition Capsule 60 Capsule(s) View ingredients & interactions Cortisol-Stress Balance by Life Extension Capsule 30 Vegetarian Capsule(s) View ingredients & interactions Cortisol-Stress Balance by Life Extension Capsule 30 Vegetarian Capsule(s) View ingredients & interactions CortiSync by PrimeGENIX Capsule 60 Cap(s) View ingredients & interactions Edge Watermelon by Amare Powder 3.17 Ounce(s) · 90 Gram(s) View ingredients & interactions Elderberry Full Spectrum CBD Gummies by Lazarus Naturals Gummy Or Jelly 40 Gummy(ies) View ingredients & interactions Elderberry Full Spectrum CBD Gummies by Lazarus Naturals Gummy Or Jelly 10 Gummy(ies) View ingredients & interactions EndoLOX by Pure Encapsulations Capsule 60 Capsule(s) View ingredients & interactions Endurance Kick by Jigsaw Health Capsule 60 Vegicap(s) View ingredients & interactions Energy & Metabolism Chocolate by GNC Women's Ultra Mega Powder 6 Oz(s) · 170 Gram(s) · 5 Packet(s) View ingredients & interactions Energy & Metabolism Chocolate by GNC Mega Men Powder 5 Packet(s) · 6.52 oz. · 185 Gram(s) View ingredients & interactions Energy & Metabolism Chocolate by GNC Mega Men Powder 39.15 Oz(s) · 2.45 lbs · 1110 Gram(s) View ingredients & interactions
Pharmacist Counseling Corner

Lychee: Common Questions

Does Lychee interact with prescription medications?
Yes. We list 207 medications with a known interaction with Lychee. Use the checker above to see how Lychee interacts with a specific drug.
How are Lychee interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Lychee with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Lychee interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Lychee good for you?
Yes, as a food. Lychee is low in fat, provides vitamin C and antioxidant plant compounds, and can be part of a healthy diet when eaten in moderation.
Is it dangerous to eat Lychee on an empty stomach?
For most well-fed adults, eating ripe Lychee in moderation is fine. The serious risk of dangerous low blood sugar has been seen mainly in malnourished children who ate large amounts of unripe Lychee while skipping meals.
Can I take Lychee supplements to treat a health condition?
There isn't strong evidence that Lychee extracts treat or prevent any specific medical condition. Talk to your pharmacist or doctor before using Lychee supplements, and don't use them in place of proven treatments.
Can I eat Lychee while pregnant?
Eating Lychee fruit in normal food amounts is likely fine during pregnancy, but concentrated extracts and supplements have not been studied, so it's safest to avoid those and check with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Lychee

A rotating sample of real supplements in our database that list Lychee — open any to see its full ingredients and every drug interaction we check.

See all 106 products with Lychee →
Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Lychee?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist