Medication interaction hub

What Supplements Interact with Ergotamine, Belladonna, Phenobarbital?

Ergotamine, Belladonna, Phenobarbital brand names: Bellaspas, Bellamine, Eperbel-S. Every interaction below applies to the brands too.

250 Interactions 11 Major 200 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ergotamine, Belladonna, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ergotamine, Belladonna, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Sedation stacking is the risk I would put first with ergotamine, belladonna, and phenobarbital (Bellamine, Bellaspas). Phenobarbital is a barbiturate, sedating on its own, and 78 of the ingredients on this page deepen that drowsiness, alcohol most seriously of all. This list deserves genuine caution, not a skim. Drug levels are the other big theme, since grapefruit can push this medicine higher while St. John's wort pulls phenobarbital down enough to weaken it, and well over a hundred entries share its metabolic pathways in one direction or the other.

Belladonna adds a third pattern, with about 30 herbs piling on the same drying, vision-blurring anticholinergic effects, and a small group can block an oral dose from absorbing, so space those well apart. Of the 250 entries, 200 are moderate and 39 minor, but eleven carry a major rating, and those eleven are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 200 Minor 39 No known interaction 1,202

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ergotamine, Belladonna, Phenobarbital: Top Interactions at a Glance

The Ergotamine, Belladonna, Phenobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ergotamine, Belladonna, Phenobarbital Combinations Today

The Ergotamine, Belladonna, Phenobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Goldthread + Ergotamine, Belladonna, Phenobarbitali

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Read the full interaction Moderate Likelihood Possible Groundsel + Ergotamine, Belladonna, Phenobarbitali

Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Read the full interaction Moderate Likelihood Probable Folic Acid + Ergotamine, Belladonna, Phenobarbitali

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.

Read the full interaction Moderate Likelihood Possible Devil's Claw + Ergotamine, Belladonna, Phenobarbitali

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Cocoa + Ergotamine, Belladonna, Phenobarbitali

Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.

Read the full interaction Minor Likelihood Possible Fucus Vesiculosus + Ergotamine, Belladonna, Phenobarbitali

Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ergotamine, Belladonna, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 250 with a Ergotamine, Belladonna, Phenobarbital interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ergotamine, Belladonna, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldthread with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Ergotamine, Belladonna, Phenobarbital answer

Can you take Groundsel with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Ergotamine, Belladonna, Phenobarbital answer

Can you take Folic Acid with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.

Full Folic Acid + Ergotamine, Belladonna, Phenobarbital answer

Can you take Devil's Claw with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Ergotamine, Belladonna, Phenobarbital answer

Can you take Cocoa with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Cocoa + Ergotamine, Belladonna, Phenobarbital answer

Can you take Ayahuasca with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bacopa with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bay Leaf with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Ergotamine, Belladonna, Phenobarbital answer

Can you take Beet with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Ergotamine, Belladonna, Phenobarbital answer

Can you take Berberine with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Ergotamine, Belladonna, Phenobarbital answer

Can you take Beta-methylphenethylamine (bmpea) with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bishop's Weed with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bitter Almond with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bitter Orange with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Ergotamine, Belladonna, Phenobarbital answer

Can you take Black Pepper with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Ergotamine, Belladonna, Phenobarbital answer

Can you take Black Seed with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Ergotamine, Belladonna, Phenobarbital answer

Can you take Black Tea with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Black Tea + Ergotamine, Belladonna, Phenobarbital answer

Can you take Bog Labrador Tea with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Ergotamine, Belladonna, Phenobarbital answer

Can you take Boneset with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Ergotamine, Belladonna, Phenobarbital answer

Can you take Borage with Ergotamine, Belladonna, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Full Borage + Ergotamine, Belladonna, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ergotamine, Belladonna, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ergotamine, Belladonna, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ergotamine, Belladonna, Phenobarbital sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Ergotamine, Belladonna, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ergotamine, Belladonna, Phenobarbital through this category.

Related: does Ergotamine, Belladonna, Phenobarbital deplete any nutrients?

Ergotamine, Belladonna, Phenobarbital has 30 reported nutrient associations in the research literature — see the Ergotamine, Belladonna, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ergotamine, Belladonna, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ergotamine, Belladonna, Phenobarbital.

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Pharmacist Counseling Corner

Ergotamine, Belladonna, Phenobarbital & Supplements: Common Questions

What supplements interact with Ergotamine, Belladonna, Phenobarbital?
More than you might expect — 250 in total, though they are far from equal: 11 are rated major, 200 moderate, and 39 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, St. John's Wort.
Which Ergotamine, Belladonna, Phenobarbital supplement interactions are the most serious?
The 11 major-rated combinations — led by Beer, Grapefruit, St. John's Wort, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ergotamine, Belladonna, Phenobarbital?
Usually yes — most people on Ergotamine, Belladonna, Phenobarbital can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Bellaspas have the same supplement interactions as Ergotamine, Belladonna, Phenobarbital?
Yes — Bellaspas, Bellamine, Eperbel-S all contain Ergotamine, Belladonna, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ergotamine, Belladonna, Phenobarbital deplete any vitamins or nutrients?
It might — Ergotamine, Belladonna, Phenobarbital has 30 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ergotamine, Belladonna, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ergotamine, Belladonna, Phenobarbital and my other medications?
This page covers Ergotamine, Belladonna, Phenobarbital against supplements and herbal ingredients. Checking Ergotamine, Belladonna, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.